"Phenergan with codeine is the brand name for the compound that includes promethazine, an antihistamine, and codeine, a narcotic, which was approved by the FDA in 1952." Promethazine with codeine is available with a prescription, both as a generic drug and under the brand name Phenergan with codeine. Promethazine with codeine is an antihistamine with sedative and anti-tussive, or cough suppressing, properties. Here's how promethazine works: During an allergic reaction, the body releases histamine, a chemical that binds to cell receptors and leads to sneezing, itching, and increased mucus production. Promethazine binds with these cell receptors, preventing histamine from doing so, and thus ending the reaction. Codeine works by entering the central nervous system, where it binds to opioid receptors located in the brain and spinal cord. This relieves discomfort by stifling the body's natural response to pain. Promethazine with codeine is used to relieve coughing and other symptoms of various allergic conditions and the common cold. Phenergan with codeine is available to be taken in syrup form. Dosages vary greatly depending on the patient's need.Because both promethazine and codeine can be addictive, never take extra doses of this medication. The most common side effects of promethazine include drowsiness, blurred vision and increased sensitivity to sun light and constipation. The most common side effects of codeine include nausea and vomiting, but you should ask your doctor for a complete list of the side effects of both.Also, be sure to tell your doctor immediately if you experience difficulty breathing, confusion, yellowing skin, severe dizziness, involuntary tics, or other significant changes. Promethazine with codeine should not be taken in conjunction with sedatives or MAO inhibitors and should be avoided by people who have breathing problems. Ask your doctor for a full list of medications and conditions that should not be combined with this compound. Phenergan with codeine can be extremely helpful for people who suffer from coughing associated with colds and allergic reaction. However, the medication should always be used under the direct care of a physician. Please ask for and review all of the information provided by your doctor before taking this medication. The information in this video is intended to supplement, not substitute for, the expertise of your physician. Always consult your doctor before using this drug.