Duloxetine is a prescription medication which is available only under the brand name Cymbalta. This medication belongs to a class of drugs known as selective serotonin norepinephrine reuptake inhibitors, or SNRIs. Like other SNRIs, Cymbalta is believed to work by increasing the brains supply of the feel-good hormones serotonin and norepinephrine. This corrects an existing chemical imbalance, improving mood and creating a feeling of well-being. Cymbalta is most commonly used in the treatment of major depressive disorder and general anxiety disorder. It can also be prescribed to treat diabetic neuropathy, or pain caused by nerve damage in people with diabetes. Cymbalta is available in twenty, thirty, and sixty milligram capsules. Cymbalta should be taken once a day with water. Once you have been taking this medication regularly, do NOT suddenly stop taking it, as serious withdrawal symptoms can occur. The most commonly reported side effects of Cymbalta include weight changes, insomnia, and decreased sex drive, but please ask your doctor for a complete list. Also, tell your doctor IMMEDIATELY if you experience suicidal thoughts, yellowing of the eyes or skin, or any other significant changes. Cymbalta should not be taken with MAO Inhibitors like Nardil, or in conjunction with alcohol. Most pain medications should also be avoided, but ask your doctor for a full list of medications and conditions that should not be combined with Cymbalta. Cymbalta can be effective at easing the symptoms of people with depression or anxiety disorders. However, this medication must always be used under the direct care of a physician. Please ask for and review all of the patient information provided by your doctor before taking Cymbalta.