Varubi

prevents nausea and vomiting caused by chemotherapy. Offers patients another treatment option to help prevent nausea and vomiting that occurs after chemotherapy.

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Pharmacist, Anyssa S. Garza, PharmD, overviews the uses and common side effects of Varubi.
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Pharmacist, Anyssa S. Garza, PharmD, overviews the uses and common side effects of Varubi.
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Varubi Overview

Reviewed: September 2, 2015
Updated: 

Varubi is a prescription medication used with other medications to help prevent nausea and vomiting that happens later with certain chemotherapy. 

It belongs to a group of drugs called antiemetics. These work to block the receptor that plays a big part in nausea and vomiting induced by certain cancer chemotherapies. 

Varubi is available in tablet form and is typically taken before you receive your chemotherapy. It can be taken with or without food. 

Common side effects include low white blood cell count, hiccups, decreased appetite and dizziness.

Do not drive or operate heavy machinery until you know how this medication affects you. 

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Varubi Cautionary Labels

precautions

Uses of Varubi

Varubi is a prescription medication used with other medications to help prevent nausea and vomiting that happens later with certain chemotherapy. 

It is not known if Varubi is safe and effective in children. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

 

Manufacturer

Varubi Drug Class

Varubi is part of the drug class:

Side Effects of Varubi

Serious side effects have been reported with Varubi. See the “Varubi Precautions” section.

The most common side effects of Varubi in people who take Varubi and Cisplatin chemotherapy medicine include:

  • low white blood cell count
  • hiccups
  • stomach pain

The most common side effects of Varubi in people who take Varubi and receive Anthracycline and Cyclophosphamide chemotherapy medicines include:

  • decreased appetite
  • low white blood cell count
  • dizziness
  • indigestion
  • urinary tract infection
  • mouth sores
  • low red blood cell count

This is not a complete list of Varubi side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Varubi Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • thioridazine. Taking Varubi with thioridazine can cause serious or life-threatening heart rhythm changes. 
  • pimozide. Your doctor will have to monitor you for prolongation of your QTc interval if you have to take both medications. 
  • other medications that use the enzyme CYP2D6 such as dextromethorphan 
  • BCRP substrates with a narrow therapeutic index such as methotrexate, topotecan, or irinotecan
  • P-gp substrates with a narrow therapeutic index such as digoxin

 

 

Varubi Precautions

Serious side effects have been reported with Varubi including the following:

Varubi can change the level of some medicines in your blood. Serious or life-threatening reactions, including heart rhythm changes, may occur if Varubi is used with certain other medicines.

Do not take Varubi if you are:

  • allergic to Varubi or any of its ingredients
  • taking pimozide or thioridazine

Varubi Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Varubi, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Varubi, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Varubi or to any of its ingredients
  • have liver problems
  • are pregnant or plan to become pregnant. It is not known if Varubi will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if Varubi passes into your breast milk or could harm your baby. 

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

 

Varubi and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

There is no available data on Varubi use in pregnant women. In animal reproduction studies, there were no teratogenic or embryo-fetal effects observed with Varubi. 

Varubi and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Varubi crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Varubi.

 

Varubi Usage

Take Varubi exactly as your doctor tells you to take it.

Varubi is available in tablet forms and is typically taken before you receive your chemotherapy. It can be taken with or without food. 

On Day 1 of chemotherapy, take 2 Varubi tablets by mouth about 1 to 2 hours before you receive your anti-cancer medicine (chemotherapy).

Do not take Varubi more than 1 time every 14 days. 

Varubi Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The recommended dose of Varubi is 180 mg 1 to 2 hours prior to the start of chemotherapy.

Take Varubi with dexamethasone and a 5-HT3 receptor antagonist. 

Varubi Overdose

If you take too much Varubi, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store Varubi at room temperature between 68°F to 77°F (20°C to 25°C).
  • Keep Varubi and all medicines out of the reach of children.