Tybost

Tybost boosts the effectiveness of several anti-HIV drugs. It works by inhibiting an enzyme that breaks down certain medications.

Tybost Overview

Reviewed: September 25, 2014
Updated: 

Tybost is a prescription medication used to increase the effectiveness of drugs that treat human immunodeficiency virus (HIV) infection.

Tybost belongs to a group of drugs called enzyme inhibitors. These work by stopping the body’s natural enzymes that metabolize drugs. Therefore, drugs that are metabolized by these enzymes are able to stay in the body for a longer period of time and have a greater effect.

This medication comes in tablet form and is taken once a day, with food.

Common side effects of Tybost include yellowing of the skin or eyes and nausea.

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Tybost Cautionary Labels

precautionsprecautionsprecautionsprecautionsprecautions

Uses of Tybost

Tybost is a prescription medication used to increase the effectiveness of drugs that treat human immunodeficiency virus (HIV) infection.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Tybost Drug Class

Tybost is part of the drug class:

Side Effects of Tybost

Serious side effects have been reported with Tybost. See the “Tybost Precautions” section.

Common side effects of Tybost include the following:

  • yellowing of the skin or eyes
  • nausea

This is not a complete list of Tybost side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tybost Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • hormone-based contraceptives (birth control pills or other hormone-based contraceptives not taken by mouth, such as patches or rings)
  • medicines for indigestion, heartburn, or ulcers
  • medicines to treat depression
  • medicines to treat cancer
  • medicines to prevent organ transplant rejection
  • medicines to treat high blood pressure
  • medicines that treat erectile dystfunction, including avanafil (Stendra), sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra, Staxyn)
  • medicines used to treat pain and addiction to narcotic pain medicines
  • medicines used to treat seizures
  • more than 1 HIV-1 protease inhibitor or an HIV-1 protease inhibitor and elvitegravir (Vitekta)
  • protease inhibitor medicines, other than atazanavir (Reyataz) or darunavir (Prezista)
  • other medicines that contain cobicistat (Stribild)
  • amiodarone (Cordarone, Pacerone)
  • atorvastatin (Lipitor, Caduet)
  • boceprevir (Victrelis)
  • bosentan (Tracleear)
  • budesonide (Entocort, Pulmicort Flexhaler, Pulmicort Respules, Rhinocort, Symbicort, Uceris)
  • buspirone
  • clarithromycin (Biaxin, Prevpac)
  • colchicine (Colcrys)
  • dexamethasone
  • diazepam (Valium)
  • digoxin (Lanoxin)
  • disopyramide (Norpace)
  • erythromycin (Benzamycin)
  • efavirenz (Atripla, Sustiva)
  • etravirine (Intelence)
  • flecainide (Tambocor)
  • fluticasone (FLovent, Flonase, Flovent Diskus, Flovent HFA, Veramyst)
  • itraconazole (Sporanox)
  • ketoconazole (Nizoral)
  • maraviroc (Selzentry)
  • mexiletine
  • nevirapine (Viramune, Viramine XR)
  • a medicine that contains perphenazine
  • propafenone (Rythmol)
  • quinidine (Neudexta)
  • rifabutin (Mycobutin)
  • risperidone (Risperdal, Rsiperdal Consta)
  • ritonavir (Norvir) or medicines that contain ritonavir such as lopinavir/ritonavir (Kaletra)
  • rivaroxaban (Xarelto)
  • rosuvastatin (Crestor)
  • salmeterol (Serevent, Advair Diskus, Advair HFA)
  • simeprevir (Olysio)
  • tadalafil (Adcirca), for the treatment of pulmonary arterial hypertension
  • telithromycin (Ketek)
  • telaprevir (Incivek)
  • thioridazine
  • timolol
  • voriconazole (Vfend)
  • warfarin (Coumadin, Jantoven)

This is not a complete list of Tybost drug interactions. Ask your doctor or pharmacist for more information.

Tybost Precautions

Serious side effects have been reported with Tybost including the following:

  • Renal impairment. Renal function should be assessed before and during treatment with Tybost, and patients who experience changes in renal function should be monitored closely.

Do not take Tybost if you:

  • are allergic to Tybost or to any of its ingredients
  • take the following drugs:
    • alfuzosin (Uroxatral)
    • dronedarone (Multaq)
    • rifampin (Rifadin)
    • irinotecan (Camptosar)
    • ergot derivatives: dihydroergotamine (Migranal), ergotamine, and methylergonovine (Methergine)
    • cisapride (not available in the United States)
    • St. John’s wort
    • lovastatin (Altoprev, Mevacor)
    • simvastatin (Zocor)
    • pimozide (Orap)
    • nevirapine (Viramune)
    • sildenafil (as Revatio for the treatment of pulmonary hypertension)
    • indinavir (Crixivan)
    • triazolam (Halcion)
    • orally administered midazolam (Versed)

Tybost Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Tybost, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Tybost, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Tybost or to any of its ingredients
  • have kidney problems
  • have liver problems
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Tybost and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X – are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Tybost falls into category B. There are no well-done studies that have been done in humans with Tybost. In animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

Tybost and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Tybost crosses into human milk. The Centers for Disease Control and Prevention recommend that HIV-infected mothers not breastfeed their infants, to avoid risking postnatal transmission of HIV. Because of both the potential for HIV transmission and the potential for serious adverse reactions in nursing infants, HIV-infected mothers should not breastfeed.

Tybost Usage

Take Tybost exactly as prescribed.

This medication comes in tablet form and is taken once a day, with food.

If you miss a dose of Tybost with atazanavir or Tybost with darunavir and you remember within 12 hours, take the missed dose of Tybost with atazanavir or darunavir right away. The next dose of Tybost with atazanavir or darunavir should be taken together as usual. If you miss a dose of Tybost with atazanavir or Tybost with darunavir and it has been more than 12 hours, wait and take the next dose at the usual time. If a dose of Tybost with atazanavir or darunavir is skipped, do not double the next dose of Tybost with atazanavir or darunavir.

Tybost Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication

The recommended dose Tybost is 150 mg orally once daily. Tybost should always be administered at the same time as atazanavir or darunavir or another anti-retroviral agent for the treatment of human immunodeficiency virus.

Tybost Overdose

If you take too much Tybost, call your healthcare provider or local Poison Control Center or seek emergency medical attention right away.

If Tybost is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Store Tybost at room temperature in the original container.
  • Keep container tightly closed.
  • Keep this and all medicines out of the reach of children.