Tuzistra XR

Tuzistra XR relieves of cough and symptoms associated with allergies or a common cold. Avoid alcohol while taking this medication.

Tuzistra XR Overview

Reviewed: May 6, 2015

Tuzistra XR is a prescription medication used to relieve cough and symptoms associated with upper respiratory allergies or the common cold. It is a single product containing 2 medications: codeine and chlorpheniramine.

Codeine belongs to a group of drugs called opiate (narcotic) analgesics and to a class of medications called antitussives. It works by decreasing the activity in the part of the brain that causes coughing. Chlorpheniramine belongs to a group of drugs called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.

This medication comes in an extended release oral suspenison and is taken typically every 12 hours (twice a day), with or without food.

Common side effects of Tuzistra XR include nausea, vomiting, and constipation. 

Tuzistra XR can also cause blurred vision, drowsiness, and dizziness. Do not drive or operate heavy machinery until you know how Tuzistra XR affects you.

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Uses of Tuzistra XR

Tuzistra XR is a prescription medication used to relieve cough and symptoms associated with upper respiratory allergies or the common cold. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.


Codeine and chlorpheniramine

For more information on this medication choose from the list of selections below.

Side Effects of Tuzistra XR

Serious side effects have been reported with Tuzistra XR . See the “Drug Precautions” section.

Common side effects of Tuzistra XR include the following:

  • nausea
  • vomiting
  • constipation
  • stomach distension
  • stomach pain
  • blurred vision
  • diplopia
  • visual disturbances
  • confusion
  • dizziness
  • depression
  • drowsiness
  • sedation
  • headache
  • euphoria
  • facial dyskinesia
  • feeling faint
  • light-headedness
  • general feeling of discomfort or illness
  • excitability
  • nervousness
  • agitation
  • restlessness
  • somnolence
  • insomnia
  • dyskinesia
  • irritability
  • tremor

This is not a complete list of Tuzistra XR side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tuzistra XR FDA Warning

WARNING: Death Related to Ultra-Rapid Metabolism of Codeine to Morphine
Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism