Trifluridine and Tipiracil

treats patients with colorectal cancer who are no longer responding to other therapies.

Trifluridine and Tipiracil Overview

Reviewed: September 24, 2015
Updated: 

Trifluridine/tipiracil is a prescription medication used to treat advanced colorectal cancer. It is a single product containing trifluridine and tipiracil. 

Trifluridine belongs to a group of drugs called nucleoside metabolic inhibitor. Tipiracil belongs to a group of drugs called thymidine phosphorylase inhibitor. Together these work to stop the growth and spread of cancer cells.

It is available in tablet form and is typically taken twice a day, within 1 hour of morning and evening meals.  

Common side effects of this medication may include decrease in blood cell counts, fatigue, and nausea.

Patient Ratings for

How was your experience with ?

First, a little about yourself

Tell us about yourself in a few words?

What tips would you provide a friend before taking ?

What are you taking for?

Choose one
  • Other

How long have you been taking it?

Choose one
  • Less than a week
  • A couple weeks
  • A month or so
  • A few months
  • A year or so
  • Two years or more

How well did work for you?

Did you experience many side effects while taking this drug?

How likely would you be to recommend to a friend?

Trifluridine and Tipiracil Cautionary Labels

precautionsprecautionsprecautionsprecautionsprecautionsprecautions

Uses of Trifluridine and Tipiracil

Trifluridine/tipiracil is a prescription medication used to treat patients with an advanced form of colorectal cancer who are no longer responding to other therapies. These therapies include fluoropyrimidine, oxaliplatin and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Trifluridine and Tipiracil Brand Names

Trifluridine and Tipiracil may be found in some form under the following brand names:

Trifluridine and Tipiracil Drug Class

Trifluridine and Tipiracil is part of the drug class:

Side Effects of Trifluridine and Tipiracil

Serious side effects have been reported with trifluridine/tipiracil. See the “Trifluridine/tipiracil Precautions” section.

Common side effects include the following:

  • anemia (low red blood cell counts)
  • neutropenia (low neutrophils)
  • fatigue
  • nausea
  • thrombocytopenia (low platelets)
  • decreased appetite
  • diarrhea
  • vomiting
  • abdominal pain
  • fever

This is not a complete list of trifluridine/tipiracil side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Trifluridine and Tipiracil Interactions

No drug interactions have been conducted by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Trifluridine and Tipiracil Precautions

Serious side effects have been reported with trifluridine/tipiracil including the following:

  • Bone marrow Suppression (Severe Myelosuppression): Contact your doctor right away if you notice signs or symptoms of infection. Your doctor will monitor your blood counts prior to and on Day 15 of each cycle. Keep all appointments for blood tests. If needed, your doctor may reduce dose and/or hold trifluridine/tipiracil. 
  • Gastrointestinal toxicity:  Contact your doctor right away if you experience severe or persistent nausea, vomiting, diarrhea, or abdominal pain.
  • Low blood counts. Patients 65 years and older are at a higher risk of having low blood counts after taking trifluridine/tipiracil. 
  • Embryo-Fetal Toxicity: Trifluridine/tipiracil can cause fetal harm when administered to a pregnant woman. Females of reproductive potential are recommended to use effective contraception during treatment with trifluridine/tipiracil. 

Trifluridine/tipiracil is available in two strengths and you may receive both strength tablets to provide the prescribed dose. Make sure to read your prescription labels carefully and take the appropriate number of tablets. 

Do not take this medication if you are allergic to trifluridine, tipiracil or to any of its ingredients.

 

Trifluridine and Tipiracil Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of trifluridine/tipiracil, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking trifluridine/tipiracil, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to trifluridine, tipiracil or to any of its ingredients
  • have liver problems
  • have kidney problems
  • have or ever had anemia (low red blood cells, neutropenia (low neutrophils) and thrombocytopenia (low platelets) 
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Trifluridine and Tipiracil and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

Trifluridine/tipiracil can cause fetal harm when administered to a pregnant woman. Females of reproductive potential are recommended to use effective contraception during treatment with trifluridine/tipiracil. 

Males with female partners of reproductive potential should use condoms during treatment with Lonsurf and for at least 3 months after the final dose.

Trifluridine and Tipiracil and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known whether trifluridine/tipiracil or its metabolites are present in human milk. There are no data to assess the effects of Lonsurf or its metabolites on the breastfed infant or the effects on milk production. Because of the potential for serious adverse reactions in breastfeeding infants, women should not breastfeed during treatment with trifluridine/tipiracil and for one day following the final dose.

Trifluridine and Tipiracil Usage

Take trifluridine/tipiracil exactly as prescribed.

It is available in tablet form and is typically taken twice a day, within 1 hour of morning and evening meals.  

Anyone else who handles this medication should wear gloves.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of trifluridine/tipiracil at the same time.

Trifluridine and Tipiracil Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your kidney function
  • your age

The recommended dose/dose range of Lonsurf (trifluridine and tipiracil) for the treatment of  is 35 mg/m2/dose orally twice daily on Days 1 through 5 and Days 8 through 12 of each 28-day cycle. 

Trifluridine and Tipiracil Overdose

If you take too much trifluridine/tipiracil, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store at 20°C to 25°C (68°F to 77°F).
  • Trifluridine/tipiracil is a cytotoxic drug. Follow applicable special handling and disposal procedures.
  • Keep this and all medicines out of the reach of children.
  • If stored outside of original bottle, discard, following disposal procedures, after 30 days.