Tretten

Tretten prevents bleeding in those with a certain type of blood clotting disorder. Tell your doctor before using this medication if you have a history of blood clots.

Tretten Overview

Reviewed: December 23, 2013
Updated: 

Tretten is a prescription medication used to prevent bleeding in people with a rare blood clotting disorder known as congenital Factor XIII A-subunit deficiency. This medication replaces an important protein necessary for normal clotting.

Tretten comes in an injectable form to be given directly into a vein (IV) by a healthcare professional. In some cases, patients can be taught to properly administer this medication.

Common side effects include headache and pain at the site of injection. 

 

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Tretten Cautionary Labels

precautions

Uses of Tretten

Tretten is a prescription medication used to prevent bleeding in patients with congenital factor XIII A-subunit deficiency.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
 

Manufacturer

Tretten Drug Class

Tretten is part of the drug class:

Side Effects of Tretten

In clinical trials, the most frequent adverse drug reactions were non-neutralizing antibodies. The antibodies had no inhibitory effect and the patients did not experience any adverse events or bleeding in association with these antibodies.

Common side effects include headache and pain at the site of injection. 
 
This is not a complete list of Tretten side effects. Ask your doctor or pharmacist for more information.

Tretten Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take factor VIIa.

This is not a complete list of Tretten drug interactions. Ask your doctor or pharmacist for more information.

Tretten Precautions

Serious side effects can occur including:

  • hypersensitivity reactions. This medication is a recombinant protein and it may cause allergic reactions including anaphylactic reaction (a severe allergic response). Tell your healthcare provider if you have signs of an allergic reaction including hives, rash, tightness of the chest, wheezing, low blood pressure and anaphylaxis.
  • thrombosis (blood clot formation). Increased levels of activated rFXIII may increase the risk of thrombosis. In case of predisposition to conditions of thrombosis, caution should be exercised due to the fibrin-stabilizing effect of this medication.
Do not take Tretten if you have congenital factor XIII B-subunit deficiency.
 
This medication has not been studied in children less than 6 years of age.
 
 
 

Tretten Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Tretten, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Tretten, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • If you are pregnant, think you may be pregnant or planning to become pregnant. It is not known if Tretten can harm you or your unborn baby.
  • Labor and Delivery: It is not known if Tretten is safe and effective during labor and delivery.
  • Breast feeding: It is not known if Tretten passes into your breast milk.
  • If you have a history of blood clots.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

 

Tretten and Pregnancy

Tell your healthcare provider if you are pregnant or planning to become pregnant. It is not known if this medication will harm your unborn baby. Tretten should be used only if the benefits clearly outweigh the risks.

Tretten and Lactation

Tell your healthcare provider if you are breastfeeding. It is not known if this medication is excreted in human breast milk or if it will harm your nursing baby. The decision to continue or discontinue breastfeeding or Tretten therapy should be based on benefits to child and mother.

Tretten Usage

  • Reconstituted (prepared) Tretten should be used immediately.
  • If it is not used immediately, it should be used within 3 hours if stored at room temperature. After this period discard it.
  • It should be used within 24 hours if stored in the refrigerator at 2ºC–8ºC. After this period discard it. 
  • Do not store reconstituted Tretten in a syringe.
  • Do not freeze reconstituted Tretten.

Tretten Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following your weight.

The recommended dose/dose range of catridecacog (Tretten) is 35 IU/kg dose.

Tretten Overdose

If you take too much Tretten, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If Tretten is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Store in refrigerator (2ºC–8ºC).
  • Store in the original package in order to protect from light.
  • Do not freeze to prevent damage to the solvent vial.