Tol-Tab

Tol-Tab Overview

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Tol-Tab is a used to treat type 2 diabetes. Tol-Tab belongs to a group of drugs called sulfonylureas, which help to lower blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body). It also helps the body use insulin efficiently.

This medication comes in tablet form and is taken once a day in the morning with breakfast or the first meal of the day.

  • The total daily dose may be taken either in the morning or in divided doses through the day.

Common side effects include nausea, feeling full, and heartburn. Tol-Tab can also cause dizziness. Do not drive or operate heavy machinery until you know how it affects you.

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  • Diabetes Mellitus, Type 2

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Tol-Tab Cautionary Labels

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Uses of Tol-Tab

Tol-Tab is a prescription medication used to treat type 2 diabetes.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Tol-Tab Drug Class

Tol-Tab is part of the drug class:

Side Effects of Tol-Tab

Common side effects include:

  • nausea
  • upper abdominal fullness
  • heartburn
  • rash
  • headache
  • changes in taste

This is not a complete list of Tol-Tab side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tol-Tab Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn)
  • salicylate pain relievers
  • sulfa antibiotics such as sulfamethoxazole/ trimethoprim (Bactrim, Septra)
  • sulfasalazine (Azulfidine)
  • probenecid (Benemid)
  • chloramphenicol
  • MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate)
  • beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal)
  • calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Isoptin, Verelan)
  • anticoagulants ('blood thinners') such as warfarin (Coumadin)
  • aspirin
  • thyroid medications
  • hormonal contraceptives (birth control pills, patches, rings, implants, and injections)
  • insulin or other medications to treat high blood sugar or diabetes
  • isoniazid (INH)
  • niacin
  • oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone)
  • phenytoin (Dilantin)
  • diuretics ('water pills')

This is not a complete list of Tol-Tab drug interactions. Ask your doctor or pharmacist for more information.

Tol-Tab Precautions

Serious side effects have been reported with Tol-Tab including the following:

  • Tol-Tab may increase your chance of death from heart problems.
  • Tol-Tab can cause low blood sugar levels (hypoglycemia) in patients. Tell your doctor if you have a history of kidney or liver disease or drink alcohol. Symptoms of low blood sugar include:
    • shakiness
    • tremors
    • cold sweat
    • fast heart rate
    • headache
    • moodiness
    • dizziness
    • blurred vision
    • confusion
  • Tol-Tab can decrease the number of red blood cells in people with glucose-6-phosphate dehydrogenase (G6PD) deficiency.  Alert your doctor if you have a history of G6PD deficiency or anemia.

Ask your doctor about the safe use of alcoholic beverages while you are taking Tol-Tab. Alcohol can make the side effects from Tol-Tab worse. Consuming alcohol while taking Tol-Tab also may cause symptoms such as flushing (reddening of the face), headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety.

Avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Tol-Tab may make your skin sensitive to sunlight.

After exposure to stress, such as fever, trauma, infection, or surgery, Tol-Tab may cause you to lose control over your blood glucose levels. These conditions can affect your blood sugar and the amount of Tol-Tab  you may need. Ask your doctor what to do in any of these cases.

Do not take Tol-Tab if you:

  • are allergic to Tol-Tab or to any of its ingredients
  • have Diabetic ketoacidosis, with or without coma. This condition should be treated with insulin.
  • are being treated for Type I diabetes (as sole therapy)

Tol-Tab Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Tol-Tab, there are no specific foods that you must exclude from your diet when receiving this medication.

 

Inform MD

Before taking Tol-Tab, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Tol-Tab or to any of its ingredients
  • have or have ever had G6PD deficiency (an inherited condition causing premature destruction of red blood cells or hemolytic anemia)
  • have hormone disorders involving the adrenal, pituitary, or thyroid gland
  • have heart, kidney, or liver disease
  • are pregnant or plan to become pregnant. If you become pregnant while taking Tol-Tab, call your doctor.
  • are breast-feeding.
  • are having surgery, including dental surgery

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

 

Tol-Tab and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Tol-Tab falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

 

Tol-Tab and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Although it is not known whether Tol-Tab is excreted in human milk, some sulfonylurea drugs are known to be excreted in human milk. Because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Tol-Tab.

If the drug is discontinued, and if diet alone is inadequate for controlling blood glucose, insulin therapy should be considered.

Tol-Tab Usage

Take Tol-Tab exactly as prescribed.

This medication comes in tablet form and is taken once a day in the morning with breakfast or the first meal of the day.

  • The total daily dose may be taken in divided doses through the day.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Tol-Tab at the same time.

Tol-Tab Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your age
  • your kidney function
  • your liver function

The recommended maintenance dose range of Tol-Tab is 0.25 to 3 grams daily. (Maintenance doses above 2 grams are seldom required)

Tol-Tab Overdose

If you take too much Tol-Tab, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store Tol-Tab 20° to 25°C (68° to 77°F).
  • Protect from light.
  • Keep this and all medicines out of the reach of children.