Ticarcillin & Clavulanate

Ticarcillin/clavulanic acid treats several types of bacterial infections. May cause upset stomach or a mild temporary rash where it is injected.

Playlist
Now Playing
Pharmacist Lindsay Morrison, PharmD overviews the uses and common side effects of Ticarcillin and clavulanic acid
Penicillins
Next Video
Penicillins
Ticarcillin and clavulanic acid
Ticarcillin and clavulanic acid
Pharmacist Lindsay Morrison, PharmD overviews the uses and common side effects of Ticarcillin and clavulanic acid
Penicillins
Penicillins
Pharmacist Nazley Mohammadi, PharmD summarizes the uses, common side effects, and warnings for the Penicillins class of medications

Ticarcillin & Clavulanate Overview

Reviewed: July 17, 2013
Updated: 

Ticarcillin/clavulanic acid is a prescription medication used to treat bacterial infections of the stomach, skin, lungs, bone, joint, and urinary tract. It is also used to treat gynecological infections. It contains 2 medications, ticarcillin and clavulanic acid.

Ticarcillin belongs to a group of drugs called penicillin antibiotics, which help stop the growth of bacteria. Clavulanic acid belongs to a group of drugs called beta lactamase inhibitors, which work by preventing bacteria from destroying ticarcillin.

This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

Common side effects of ticarcillin/clavulanic acid include rash, nausea, diarrhea, and irritation at the site of injection.

Patient Ratings for Ticarcillin & Enzyme Inhibitor

How was your experience with Ticarcillin & Enzyme Inhibitor?

First, a little about yourself

Tell us about yourself in a few words?

What tips would you provide a friend before taking Ticarcillin & Enzyme Inhibitor?

What are you taking Ticarcillin & Enzyme Inhibitor for?

Choose one
  • Other

How long have you been taking it?

Choose one
  • Less than a week
  • A couple weeks
  • A month or so
  • A few months
  • A year or so
  • Two years or more

How well did Ticarcillin & Enzyme Inhibitor work for you?

Did you experience many side effects while taking this drug?

How likely would you be to recommend Ticarcillin & Enzyme Inhibitor to a friend?

Uses of Ticarcillin & Clavulanate

Ticarcillin/clavulanic acid is a prescription medication used to treat bacterial infections of the stomach, skin, lungs, bone, joint, and urinary tract. It is also used to treat gynecological infections.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Ticarcillin & Clavulanate Drug Class

Ticarcillin & Clavulanate is part of the drug class:

Side Effects of Ticarcillin & Clavulanate

Serious side effects have been reported with ticarcillin/clavulanic acid. See the “Drug Precautions” section.

Common side effects of ticarcillin/clavulanic acid include rash, nausea, diarrhea, and irritation at thE site of injection.

This is not a complete list of ticarcillin/clavulanic acid side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Ticarcillin & Clavulanate Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

This is not a complete list of ticarcillin/clavulanic acid drug interactions. Ask your doctor or pharmacist for more information.

Ticarcillin & Clavulanate Precautions

Serious side effects have been reported with ticarcillin/clavulanic acid including:

  • hypersensitivity (severe allergic reaction). This type of reaction may be serious and possibly fatal. These reactions are more likely to occur in those with a history of penicillin hypersensitivity and/or a history of sensitivity to multiple allergens. Tell your healthcare provider right away if you start to develop signs or symptoms of a hypersensitivity reaction, which include the following:
    • chest pain
    • swelling of the face, eyes, lips, tongue, arms, or legs
    • difficulty breathing or swallowing
    • fainting
    • rash
  • diarrhea. Diarrhea is a common problem caused by antibiotics, and it usually ends when the antibacterial is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as 2 or more months after having taken their last dose of the antibacterial. If diarrhea is severe or lasts more than 2 or 3 days, contact your doctor, as this may be a sign of an infection of the bowels.
  • superinfection. ticarcillin/clavulanic acid should not be used for extended periods. Prolonged use can lead to the growth of dangerous organisms that are resistant or unaffected by ticarcillin/clavulanic acid. Take this medication for the duration prescribed by your doctor.
  • bleeding abnormalities. Your health care provider may want to monitor lab tests that show how well your blood is able to clot or that measure your tendency to bleed. Any abnormalities or irregularities that may occur may be more common in those with kidney dysfunction.
  • seizures. Some may experience a seizure when the dose of ticarcillin/clavulanic acid exceeds the recommended dose, especially for those with kidney dysfunction.

Do not take ticarcillin/clavulanic acid if you are allergic to ticarcillin/clavulanic acid or any of its ingredients, or if you are allergic to other beta lactam antibiotics (cephalosporins, penicillins).

Ticarcillin & Clavulanate Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of ticarcillin/clavulanic acid, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking ticarcillin/clavulanic acid , tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to ticarcillin/clavulanic acid or any of its ingredients
  • are allergic to similar antibiotics (penicillins, cephalosporins)
  • have other types of allergies
  • have cystic fibrosis
  • have a history of seizures
  • have kidney problems
  • are on a sodium restricted diet
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Ticarcillin & Clavulanate and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Ticarcillin/clavulanic acid falls into category B. There are no well-done studies that have been done in humans with ticarcillin/clavulanic acid. But in animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

Ticarcillin & Clavulanate and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if ticarcillin/clavulanic acid crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using ticarcillin/clavulanic acid.

Ticarcillin & Clavulanate Usage

This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

Ticarcillin & Clavulanate Dosage

The ticarcillin/clavulanic acid dose your doctor recommends will be based on:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your kidney function
  • your age
  • your weight

Adults

  • The recommended dose for systemic and urinary tract infections in adults is 3.1 grams of ticarcillin/clavulanic acid (3 grams ticarcillin and 100 mg clavulanic acid) given every 4 to 6 hours.
  • The recommended dose for gynecologic infections in adults is as follows (based on ticarcillin content):
    • Moderate infections – 200 mg/kg/day in divided doses every 6 hours
    • Severe infections – 300 mg/kg/day in divided doses every 4 hours
    • For patients weighing less than 60 kg, the recommended dosage is 200 to 300 mg/kg/day given in divided doses every 4 to 6 hours

Children less than 60 kg

  • Mild to moderate infections – 200 mg/kg/day based on the ticarcillin content in divided doses every 6 hours
  • Severe infections – 300 mg/kg/day based on the ticarcillin content in divided doses every 4 hours

Children greater than or equal to 60 kg

  • Mild to moderate infections – 3.1 grams every 6 hours
  • Severe infections – 3.1 grams every 4 hours

Ticarcillin & Clavulanate Overdose

If ticarcillin/clavulanic acid is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.