Technivie treats hepatitis C virus. It is given with ribavirin for 12 weeks. Does not require co-use of interferon.
Technivie is a prescription medication used to treat genotype 4 chronic hepatitis C virus (HCV) infection without cirrhosis. It is given in combination with ribavirin for 12 weeks.
It is a single product containing 3 ingredients: ombitasvir, paritaprevir and ritonavir.
Ombitasvir belongs to a group of drugs called NS5A inhibitors. Paritaprevir belongs to a group of drugs called NS3/4A protease inhibitor. Ritonavir is in a class of medications called protease inhibitors. Together these help to stop the virus that causes hepatitis C from spreading inside the body.
This medication comes in tablet form and is taken once a day, with a meal without regard to fat or calorie content.
Common side effects of Technivie include feeling weak, tiredness, nausea, and sleep problems. Do not drive or operate heavy machinery until you know how this medication affects you.
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Technivie Cautionary Labels
Uses of Technivie
Technivie is a prescription medication used to treat genotype 4 chronic hepatitis C virus (HCV) infection without cirrhosis. It is given in combination with ribavirin for 12 weeks. It is not known if Technivie is safe and effective in children under 18 years of age.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
For more information on this medication choose from the list of selections below.
Technivie Drug Class
Technivie is part of the drug class:
Side Effects of Technivie
Serious side effects have been reported with Technivie. See the "Technivie Precautions" section.
Common side effects of Technivie include the following:
- feeling weak
- sleep problems
Do not drive or operate heavy machinery until you know how this medication will affect you.
This is not a complete list of Technivie side effects. Ask your doctor or pharmacist for more information.
Tell your doctor if you have any side effect that bothers you or that does not go away.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
- alfuzosin hydrochloride (Uroxatral)
- carbamazepine (Carbatrol, Epitol, Equetro, Tegretol)
- efavirenz (Atripla, Sustiva)
- ergot containing medicines including: ergotamine tartrate (Cafergot, Ergomar, Ergostat, Medihaler, Migergot, Wigraine, Wigrettes), dihydroergotamine mesylate (D.H.E. 45, Migranal), and methylergonovine (Ergotrate, Methergine)
- ethinyl estradiol-containing medicines: combination birth control pills or patches (such as Lo Loestrin FE, Norinyl, Ortho TriCyclen Lo, and Ortho Evra), hormonal vaginal rings (such as NuvaRing), and the hormone replacement therapy medicine, Fem HRT
- cholesterol lowering medications such as lovastatin (Advicor, Altoprev, Mevacor) and simvastatin (Simcor, Vytorin, Zocor)
- midazolam, when taken by mouth
- triazolam (Halcion) when taken by mouth
- phenytoin, (Dilantin, Phenytek)
- phenobarbital (Luminal)
- pimozide (Orap)
- rifampin (Rifadin, Rifamate, Rifater, Rimactane)
- sildenafil citrate (Revatio), when taken for pulmonary artery hypertension (PAH)
- St. John’s wort (Hypericum perforatum) or a product that contains St. John’s wort
This is not a complete list of Technivie drug interactions. Ask your doctor or pharmacist for more information.
Serious side effects have been reported with Technivie including the following:
- Technivie can cause increases in your liver function blood test results, especially if you use ethinyl estradiol-containing medicines (such as some birth control products).
- You must stop using ethinyl estradiol-containing medicines before you start treatment with Technivie.
- If you use these medicines as a method of birth control, you must use another method of birth control during treatment with Technivie, and for about 2 weeks after you finish treatment with Technivie. Your healthcare provider will tell you when you may begin taking ethinyl estradiol containing medicines.
- Your healthcare provider should do blood tests to check your liver function during the first 4 weeks and then as needed, during treatment with Technivie.
- Serious liver injury. This may occur mostly in patients with underlying advanced liver disease. Your healthcare provider may tell you to stop taking Technivie if you develop signs or symptoms of liver problems. Tell your healthcare provider right away if you develop any of the following symptoms, or if they worsen during treatment with Technivie:
- loss of appetite
- nausea and vomiting
- yellowing of your skin or eyes
- color changes in your stools
- Multiple Drug Interactions. Technivie can interact with many medications.
- Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
- Keep a list of your medicines to show your healthcare provider and pharmacist.
- Ask your healthcare provider or pharmacist for a list of medicines that interact with Technivie.
- Do not start taking a new medicine without telling your healthcare provider. Your healthcare provider can tell you if it is safe to take Technivie with other medicines.
- When you finish treatment with Technivie:
- If your doctor changed the dose of one of your usual medicines during treatment with Technivie: Ask your healthcare provider about when you should change back to your original dose after you finish treatment with Technivie.
- If your doctor told you to stop taking one of your usual medicines during treatment with Technivie: Ask your healthcare provider if you should start taking these medicines again after you finished treatment with Technivie.
Do not take Technivie if you:
Technivie Food Interactions
Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Technivie, there are no specific foods that you must exclude from your diet when receiving Technivie.
Before taking Technivie, tell your doctor about all of your medical conditions. Especially tell your doctor if you:
- are allergic to Technivie or any of its ingredients
- have had a severe skin rash after taking ritonavir (Norvir)
- if you have a history of hepatitis B infection
- have liver problems other than hepatitis C infection
- have had a liver transplant. If you take the medicines tacrolimus (Prograf) or cyclosporine (Gengraf, Neoral, Sandimmune) to help prevent rejection of your transplanted liver, the amount of these medicines in your blood may increase during treatment with Technivie.
- Your healthcare provider should check the level of tacrolimus or cyclosporine in your blood, and if needed may change your dose of these medicines or how often you take them. When you finish taking Technivie or if you have to stop Technivie for any reason, your healthcare provider should tell you what dose of tacrolimus or cyclosporine to take and how often you should take it.
- are pregnant or plan to become pregnant
- are breastfeeding or plan to breastfeed
- you take any of the listed medications in Drug Interactions Section
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Technivie and Pregnancy
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
Technivie falls into category B. There are no well-done studies that have been done in humans with Technivie. In animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication. It is not known if Technivie will harm your unborn baby. Technivie should not be given to pregnant women or in men whose female partners are pregnant.
Technivie and Lactation
Tell your doctor if you are breastfeeding or plan to breastfeed.
It is not known if Technivie is excreted in human breast milk or if it will harm your nursing baby. Because many drugs are present in human milk and because of the potential for serious adverse reactions in nursing infants from Technivie, your doctor will determine the risk versus benefit of using this medication. Talk to your healthcare provider about the best way to feed your baby if you take Technivie.
Take Technivie exactly as your healthcare provider tells you to take it.
- Do not change your dose unless your healthcare provider tells you to.
- Do not stop taking Technivie without first talking with your healthcare provider.
- Take 2 Technivie tablets every day in the morning, with a meal.
- Technivie is given in combination with ribavirin for 12 weeks.
- Technivie is supplied in monthly cartons that contain enough medicine for 28 days. Each monthly carton of Technivie contains 4 smaller cartons. Each of the 4 smaller cartons contains enough child resistant daily dose packs of medicine to last for 7 days (1 week). Each daily dose pack contains all of your Technivie medicine for 1 day (2 tablets). Follow the instructions on each daily dose pack about how to remove the tablets.
- If you miss a dose of Technivie tablets, and it is less than 12 hours from the time you usually take your dose, take the missed dose with a meal as soon as possible. Then take your next dose at your usual time with a meal.
- If you miss a dose of Technivie tablets, and it is more than 12 hours from the time you usually take your dose, skip the missed dose. Then take your next dose at your usual time with a meal.
- Do not take more than your prescribed dose of Technivie to make up for a missed dose.
- When you finish treatment with Technivie:
Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
The dose and duration your doctor recommends may be based on the following:
- how you respond to this medication
- the condition of your liver
The recommended dose of Technivie to treat hepatitis C virus is two tablets taken orally once daily (in the morning) with a meal without regard to fat or calorie content. Technivie is recommended to be used in combination with ribavirin.
If you take too much Technivie call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.
- Store Technivie at or below 86°F (30°C).
- Keep this and all medications out of the reach of children.
Technivie FDA Warning
There is a risk of hepatitis B virus (HBV) becoming an active infection in those who have a current or previous infection with HBV and is treated with a certain antiviral medication (a direct-acting antiviral) to treat hepatitis C virus. Your healthcare provider will screen and monitor for HBV in those taking a direct-acting antiviral. Tell your healthcare provider if you have a history of hepatitis B infection or other liver problems before you are treated for hepatitis C.