Synvisc-One

Synvisc-One treats the pain of osteoarthritis (OA) of the knee. It is specifically designed to replace the fluid in the knee, lubricating the joint and provides the necessary cushion.

Synvisc-One Overview

Reviewed: November 12, 2015
Updated: 

Synvisc-One treats osteoarthritis (OA) of the knee in patients who have not found adequate response from physical therapy and pain relievers.

It helps relieves arthritis of the knee, because it replaces the lubricating fluid inside the knee. 

Synvisc-One is a single-dose treatment that is injected directly into your knee by a doctor, usually a specialist trained in treating knee osteoarthritis, such as an orthopaedic surgeon or rheumatologist. Synvisc-One is the same formulation as Synvisc. The only difference is that Synvisc-One is provided with one injection, compared to the three injections required for Synvisc.

Common side effects of Synvisc-One include pain, swelling, heat, redness and/or fluid build-up around the knee. 

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Uses of Synvisc-One

Synvisc-One treats osteoarthritis (OA) of the knee in patients who have not found adequate response from physical therapy and pain relievers. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Side Effects of Synvisc-One

Serious side effects have been reported with Synvisc-One. See the “Synvisc-One Precautions” section.

Common side effects of Synvisc-One include the following in or around the knee:

  • pain
  • swelling
  • heat
  • redness
  • fluid build-up

These reactions are generally mild and do not last long. Your doctor may recommend rest and applying ice to the injected knee.

This is not a complete list of Synvisc-One side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Synvisc-One Interactions

No drug interactions have been evaluated by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Synvisc-One Precautions

Serious side effects have been reported with Synvisc-One, incuding the following:

Allergic reactions. Serious allergic reactions have occured with Synvisc-One. Tell your healthcare provider about any signs or symptoms of hypersensitivity, which include the following:

  • chest pain
  • swelling of the lips, eyes, tongue, face, arms, or legs
  • difficulty breathing or swallowing
  • rash

Low platelets. Rarely, Synvisc-One has caused a low number of platelets (a type of blood cell that is needed to help your blood clot) in the blood.

You should not receive Synvisc-One if you:

  • are allergic to Synvisc-One or to any of its ingredients
  • are allergic to products from birds, such as feathers, eggs, or poultry
  • have an infection or skin disease in the area in which the injection is to be given

Synvisc-One Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Synvisc-One, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before receiving Synvisc-One, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Synvisc-One or to any of its ingredients
  • are allergic to products from birds, such as feathers, eggs, or poultry
  • have an infection or skin disease in the area in which the injection is to be given
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Synvisc-One and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

There have been no studies in pregnant women with Synvisc-One. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child. You and your doctor should discuss these risks and benefits and decide if Synvisc-One is right for you.

Synvisc-One and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Synvisc-One crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Synvisc-One.

Synvisc-One Usage

Synvisc-One is available as an injection and is injected into the knee by a healthcare provider. 

It is recommended that you do not perform strenuous activities or prolonged (longer than 1 hour) weight-bearing activities such as jogging for 48 hours after receiving an injection of Synvisc-One. Your doctor will tell you when you can safely resume these activities.

Synvisc-One Dosage

The recommended dose of Synvisc-One is one single injection given into the knee by your healthcare provider. In studies, one injection provided pain relief that can last for up to 6 months.

This dose may be repeated as determined by your healthcare provider.

Synvisc-One Overdose

If Synvisc-One is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.