Sylvant

treats a rare disease called Multicentric Castleman's disease (MCD). Tell your doctor if you have an infection as you shouldn't receive Sylvant if you have a severe infection.

Sylvant Overview

Reviewed: April 24, 2014
Updated: 

Sylvant is a prescription medication used to treat a rare disease of lymph nodes and related tissues called multicentric Castleman's disease (MCD). While not officially a cancer, MCD acts similarly to Lymphoma, a cancer of the lymph nodes. MCD causes an abnormal overgrowth of immune cells in lymph nodes and related tissues in the body.

Sylvant is an injection that works by blocking a protein that stimulates abnormal growth of immune cells. 

Common side effects include itchy skin (pruritis), weight gain, rash, increased levels of uric acid in the blood and upper respiratory tract infection.

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Sylvant Cautionary Labels

precautionsprecautionsprecautionsprecautionsprecautions

Uses of Sylvant

Sylvant is a prescription medication used to treat multicentric Castleman's disease (MCD). It is intended for patients with MCD who do not have HIV or human herpes virus 8 (HHV-8).

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Sylvant Drug Class

Sylvant is part of the drug class:

Side Effects of Sylvant

Serious side effects have been reported with Sylvant. See the “Sylvant Precautions” section.

Common side effects of Sylvant include the following:

  • rash
  • itchy skin (pruritis)
  • upper respiratory tract infection
  • weight gain
  • increased blood level of uric acid

This is not a complete list of Sylvant side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

 

Sylvant Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • medications that use the enzyme CYP450 such as:

This is not a complete list of Sylvant drug interactions. Ask your doctor or pharmacist for more information.

 

Sylvant Precautions

Serious side effects have been reported with Sylvant including the following:

  • Infections. Sylvant may lower your ability to fight infections. Tell your healthcare provider right away if you have any signs or symptoms of an infection during treatment with Sylvant.
  • Infusion and allergic reactions. If you have an infusion or allergic reaction while receiving Sylvant, your healthcare provider will stop your infusion and treat your reaction. If you have a severe infusion or allergic reaction, your healthcare provider may stop your treatment completely. Tell your healthcare provider or get medical help right away if you have any of these symptoms during or after your infusion of Sylvant:
    • trouble
    • breathing
    • chest
    • tightness
    • wheezing
    • dizziness
    • or light-headedness, swelling of the lips, or skin rash

Do not take Sylvant if you are allergic to Sylvant or to any of its ingredients.

Sylvant Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Sylvant, there are no specific foods that you must exclude from your diet when receiving this medication.

 

Inform MD

Before taking Sylvant, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Sylvant or to any of its ingredients
  • have an infection. You should not receive Sylvant if you have a severe infection.
  • have had a recent vaccination or are scheduled to receive any vaccinations. You should not receive a live vaccine during your treatment with Sylvant.
  • have or have had any stomach or bowel (intestine) problems, such as diverticulitis or ulcers. Tell your healthcare provider if you have pain in your stomach area.
  • are pregnant or plan to become pregnant. It is not known if Sylvant will harm your unborn baby. You should not become pregnant while receiving treatment with Sylvant. Females who are able to become pregnant should use effective birth control during treatment with Sylvant and for 3 months after stopping treatment.
  • are breastfeeding or plan to breastfeed. It is not known if Sylvant passes into your breast milk. You and your healthcare provider should decide if you will take Sylvant or breastfeed. You should not do both.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Sylvant and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Sylvant falls into category C. There are no well-controlled studies that have been done in pregnant women. Sylvant should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

Sylvant and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Sylvant crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Sylvant.

 

Sylvant Usage

Take Sylvant exactly as prescribed.

Sylvant is available in an injectable form to be given directly into a vein (IV) by a healthcare professional and is given over 1 hour by intravenous infusion every 3 weeks.

If you miss a dose, be sure to make a follow up appointment.

Sylvant Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based your weight.

The recommended dose of Sylvant for the treatment of multicentric Castleman's disease (MCD) is 11 mg/kg dose given over 1 hour by intravenous infusion every 3 weeks.

Sylvant Overdose

If Sylvant is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

 

Other Requirements

  • Keep all appointments with your doctor.