Sugammadex

Sugammadex reverses the effects of certain neuromuscular blocking drugs. Sugammadex is the first drug approved in a new class of medications.

Sugammadex Overview

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Sugammadex is a prescription medication used to reverse the effects of certain neuromuscular blocking drugs used during surgery. Sugammadex belongs to a group of drugs called antidotes. These work by helping patients recover from medications used for intubation or ventilation during surgery.

This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

Common side effects of sugammadex include vomiting, low blood pressure, and pain.

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Uses of Sugammadex

Sugammadex is a prescription medication used to reverse the effects of the neuromuscular blocking medications rocuronium bromide and vecuronium bromide, which are used during certain types of surgery in adults.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Sugammadex Brand Names

Sugammadex may be found in some form under the following brand names:

Sugammadex Drug Class

Sugammadex is part of the drug class:

Side Effects of Sugammadex

Serious side effects have been reported with sugammadex. See the "Drug Precautions" section.

Common side effects of sugammadex include the following:

  • low blood pressure (hypotension)
  • vomiting
  • pain
  • headache
  • nausea

This is not a complete list of sugammadex side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Sugammadex Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • toremifene (Fareston)
  • hormonal contraceptives (birth control) containing an estrogen or progestogen. Sugammadex will make hormonal contraceptives less effective. If a hormonal contraceptive is taken on the same day that you receive sugammadex, you will need to use an effective back-up method of birth control (such as condoms or spermicides) for the next 7 days.

This is not a complete list of sugammadex drug interactions. Ask your doctor or pharmacist for more information.

Sugammadex Precautions

Serious side effects have been reported with sugammadex including the following:

Anaphylaxis and hypersensitivity (severe allergic reaction). Tell your healthcare provider about any signs or symptoms of hypersensitivity, which include the following:

  • chest pain
  • swelling of the face, eyes, lips, tongue, arms, or legs
  • difficulty breathing or swallowing
  • rash

Marked bradycardia (slow heart rate). Sugammadex may cause a severe slow heartbeat that could be serious. Your doctor will closely monitoring your heart rate if you receive sugammadex.

Respiratory monitoring during recovery. If you need to receive sugammadex, your doctor will take steps to make sure you are able to breathe, including putting you on a ventilator (a machine that helps you breathe) until you are able to adequately breathe on your own.

Your doctor will not use sugammadex if you are allergic to sugammadex or to any of its ingredients.

Sugammadex Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of sugammadex, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to sugammadex or to any of its ingredients
  • have kidney problems
  • have liver problems
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed
  • are taking hormonal contraceptives (birth control)
  • have heart problems
  • have problems with your lungs or breathing
  • take any medications that increase your risk of bleeding, such as warfarin (Coumadin), rivaroxaban (Xarelto), or dabigatran (Pradaxa)

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Sugammadex and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

There have been no studies that have been done in pregnant women with sugammadex. In animal studies, pregnant animals were given this medication and some babies were harmed. If you receive sugammadex, talk to your doctor about the potential risks associated with pregnancy.

Sugammadex and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if sugammadex crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or not to use this medication. Your doctor and you will decide if the benefits outweigh the risk of using sugammadex.

Sugammadex Usage

Sugammadex comes in injectable form to be given directly into a vein (IV) by a trained healthcare professional. Sugammadex is administered as a single injection. Your doctor will closely monitor you to determine dosing and timing of sugammadex administration.

Sugammadex Dosage

The dose of sugammadex that your doctor gives you will be based on your weight and which medication was used for intubation or ventilation during surgery. Your doctor will closely monitor you during your recovery.

Sugammadex Overdose

If sugammadex is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.