Sivextro

Sivextro treats serious skin infections. May cause nausea, vomiting, or diarrhea. Report persistent diarrhea to your physician.

Sivextro Overview

Reviewed: June 26, 2014
Updated: 

Sivextro is a prescription medication used to treat infections of the skin.

Sivextro belongs to a group of drugs called antibacterials. These work by stopping the growth of bacteria.

Sivextro comes in tablet form (by mouth) and is taken once a day, with or without food.

This medication is also available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

Common side effects of nausea, headache, diarrhea, and vomiting.

Sivextro can also cause dizziness. Do not drive or operate heavy machinery until you know how Sivextro affects you.

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Sivextro Cautionary Labels

precautionsprecautionsprecautions

Uses of Sivextro

Sivextro is a prescription medication used to treat infections of the skin.

Sivextro is used to treat acute bacterial skin and skin structure infections caused by certain susceptible bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Sivextro Drug Class

Sivextro is part of the drug class:

Side Effects of Sivextro

Serious side effects have been reported with Sivextro. See the “Sivextro Precautions” section.

Common side effects of Sivextro include the following:

  • nausea
  • headache
  • diarrhea
  • vomiting
  • dizziness

This is not a complete list of Sivextro side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Sivextro Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Sivextro has the potential to interact with the following medications, although Sivextro has not been studied in patients on these medications.

  • selective serotonin reuptake inhibitors (SSRIs) such as escitalopram (Lexapro), sertraline (Zoloft), citalopram (Celexa), vilazodone (Viibryd), paroxetine (Paxil), fluoxetine (Prozac, Sarafem, Symbyax), and fluvoxamine (Luvox)
  • tricyclic antidepressants such as trimipramine (Surmontil), amitriptyline (Elavil), nortriptyline (Pamelor, Aventyl), protriptyline (Vivactil), and clomipramine (Anafranil)
  • medications used to treat migraines (selective serotonin receptor agonists) such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex) and zolmitriptan (Zomig)
  • meperidine (Demerol)
  • buspirone
  • Monoamine oxidase inhibitors such as
    • isocarboxazid (Marplan)
    • phenelzine (Nardil)
    • tranylcypromine (Parnate)
    • selegiline (Emsam, Eldepryl, Zelapar)
    • rasagiline (Azilect)

This is not a complete list of Sivextro drug interactions. Ask your doctor or pharmacist for more information.

Sivextro Precautions

Serious side effects have been reported with Sivextro including the following:

  • Clostridium difficile-associated diarrhea (CDAD). Some antibiotics can kill the “good” bacteria in the colon leading to a growth of C. difficile bacteria. This “bad” bacterium can cause diarrhea and other digestive problems, and these problems may even occur 2 months after the last dose. Extra caution for this side effect is advised in the elderly population. Tell your healthcare provider if you experience any or all of the following symptoms:
    • watery diarrhea (at least three bowel movements per day for two or more days)
    • loss of appetite
    • abdominal pain or tenderness
    • nausea

(Diarrhea is a common problem caused by antibiotics, and it usually ends when the antibacterial is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as 2 or more months after having taken their last dose of the antibacterial. If diarrhea is severe or lasts more than 2 or 3 days, contact your doctor, as this may be a sign of an infection of the bowels.)

  • Reduced blood counts. A decrease in white blood cells, platelets, and red blood cells may occur. Your doctor will need to conduct lab to monitor for this. Report shortness of breath, significant fatigue, bleeding, fever, or other signs of infection.

Sivextro can cause dizziness. Do not drive or operate heavy machinery until you know how Sivextro affects you.

Do not take Sivextro if you are allergic to Sivextro or to any of its ingredients.

Sivextro Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Sivextro, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Sivextro, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Sivextro or to any of its ingredients
  • have neutropenia
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Sivextro and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Sivextro falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Sivextro and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Sivextro crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Sivextro.

 

Sivextro Usage

Take Sivextro exactly as prescribed.

Sivextro comes in tablet form (by mouth) and is taken once a day, with or without food.

This medication is also available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

If you miss a dose, take the missed dose as soon as possible anytime up to 8 hours prior to their next scheduled dose.  If less than 8 hours remain before the next dose, wait until their next scheduled dose. Do not take two doses of Sivextro at the same time.

 

Sivextro Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The recommended dose of tedizolid (Sivextro) is 200 mg administered once daily for six (6) days.

Sivextro Overdose

If you take too much Sivextro, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If Sivextro is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Store Sivextro at room 20°C to 25°C (68°F to 77°F).
  • Keep this and all medicines out of the reach of children.