Seroquel is used to treat the symptoms of schizophrenia. Seroquel can cause weight gain and can increase cholesterol levels, blood sugar, and blood pressure.

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Pharmacist Steve Lozano, PharmD overviews the uses and common side effects of Seroquel
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Pharmacist Steve Lozano, PharmD overviews the uses and common side effects of Seroquel
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Seroquel Overview


Seroquel is a prescription medication used to treat several different mental disorders including schizophrenia, bipolar disorder, and depressive episodes associated with bipolar disorder. Seroquel belongs to a group of drugs called antipsychotics. The exact way Seroquel works is unclear, but it is proposed to regulate certain chemicals in the brain.

This medication comes in tablet form and is usually taken once or twice daily. Take without food or with a light meal (approx. 300 calories).

Common side effects of Seroquel are sleepiness, dizziness, and dry mouth. This medication may cause drowsiness. Do not drive or operate heavy machinery until you know how Seroquel affects you.

Patient Ratings for SEROquel

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What are you taking SEROquel for?

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  • Other
  • Autistic Disorder
  • Bipolar Disorder
  • Psychotic Disorders
  • Schizophrenia And Disorders With Psychotic Features

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  • Less than a week
  • A couple weeks
  • A month or so
  • A few months
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Seroquel Cautionary Labels


Uses of Seroquel

Seroquel is a prescription medication used to treat several different mental disorders including schizophrenia, bipolar disorder, and depressive episodes associated with bipolar disorder.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.


Seroquel Drug Class

Seroquel is part of the drug class:

Side Effects of Seroquel

Serious side effects have been reported with Seroquel. See the “Seroquel Precautions” section for additional information.

Possible side effects of Seroquel include:

  • Neuroleptic malignant syndrome (NMS): NMS is a rare but very serious condition that can happen in people who take antipsychotic medicines, including Seroquel. NMS can cause death and must be treated in a hospital. Call your doctor right away if you become severely ill and have some or all of these symptoms:
  • Tardive dyskinesia: Tell your healthcare provider about any movements you cannot control in your face, tongue, or other body parts. These may be signs of a serious condition. Tardive dyskinesia may not go away, even if you stop taking quetiapine. Tardive dyskinesia may also start after you stop taking Seroquel.
  • Orthostatic hypotension (decreased blood pressure): lightheadedness or fainting caused by a sudden change in heart rate and blood pressure when rising too quickly from a sitting or lying position.
  • Increases in blood pressure: reported in children and teenagers. Your healthcare provider should check blood pressure in children and adolescents before starting Seroquel and during therapy. Seroquel is not approved for patients under 18 years of age.
  • Low white blood cell count
  • Cataracts
  • Seizures
  • Abnormal thyroid tests: Your healthcare provider may do blood tests to check your thyroid hormone level.
  • Increases in prolactin levels: Your healthcare provider may do blood tests to check your prolactin levels.
  • Increases in liver enzymes: Your healthcare provider may do blood tests to check your liver enzyme levels.
  • Long lasting and painful erection
  • Difficulty swallowing
  • high fever
  • excessive sweating
  • rigid muscles
  • confusion
  • changes in your breathing, heartbeat, and blood pressure

Common possible side effects with Seroquel include:

  • drowsiness
  • dry mouth
  • constipation
  • dizziness
  • increased appetite
  • upset stomach
  • weight gain
  • fatigue
  • disturbance in speech and language
  • stuffy nose

These are not all the possible side effects of Seroquel. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Seroquel Interactions

Tell your healthcare provider about all the medicines that you take or recently have taken including prescription medicines, nonprescription medicines, herbal supplements and vitamins.

Seroquel and other medicines may affect each other causing serious side effects. Seroquel may affect the way other medicines work, and other medicines may affect how Seroquel works.

Especially tell your healthcare provider if you take or plan to take medication for:

  • depression
  • high blood pressure
  • Parkinson's disease
  • trouble sleeping
  • abnormal heart beats or rhythm

Also tell your healthcare provider if you take or plan to take any of these medicines:

  • phenytoin, divalproex or carbamazepine (for epilepsy)
  • barbiturates (to help you sleep)
  • rifampin (for tuberculosis)
  • glucocorticoids (steroids for inflammation)
  • thioridazine (an antipsychotic)
  • ketoconazole, fluconazole or itraconazole (for fungal infections)
  • erythromycin (an antibiotic)
  • protease inhibitors (for HIV)

This is not a complete list of medicines that can affect or be affected by Seroquel. Your doctor can tell you if it is safe to take Seroquel with your other medicines. Do not start or stop any medicines while taking Seroquel without talking to your healthcare provider first. Know the medicines you take. Keep a list of your medicines to show your healthcare provider and pharmacist when you get a new medicine.

Tell your healthcare provider if you are having a urine drug screen because Seroquel may affect your test results. Tell those giving the test that you are taking Seroquel.

Seroquel Precautions

Seroquel may cause serious side effects, including the following:

  • Risk of death in the elderly with dementia. Medicines like Seroquel can increase the risk of death in elderly people who have memory loss (dementia). Seroquel is not approved for treating psychosis in the elderly with dementia.
  • Risk of suicidal thoughts or actions (antidepressant medicines, depression and other serious mental illnesses, and suicidal thoughts or actions. Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Some people may have a particularly high risk of having suicidal thoughts or actions. These include people who have (or have a family history of) depression, bipolar illness (also called manic-depressive illness), or suicidal thoughts or actions. How can I watch for and try to prevent suicidal thoughts and actions in myself or a family member? Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed. Call the healthcare provider right away to report new or sudden changes in mood, behavior, thoughts, or feelings. Keep all follow-up visits with the healthcare provider as scheduled. Call the healthcare provider between visits as needed, especially if you have concerns about symptoms.
  • Risk of suicidal thoughts or actions
  • High fat levels in your blood (increased cholesterol and triglycerides). High fat levels may happen in people treated with Seroquel. You may not have any symptoms, so your doctor may decide to check your cholesterol and triglycerides during your treatment with Seroquel.
  • Increase in weight (weight gain). Weight gain is common in people who take Seroquel so you and your doctor should check your weight regularly. Talk to your doctor about ways to control weight gain, such as eating a healthy, balanced diet, and exercising.

Talk to you or your family member’s healthcare provider about all risks and benefits of treatment with antidepressant medicines and all treatment choices for depression or other serious mental illness.

Call a healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you:

  • thoughts about suicide or dying
  • attempts to commit suicide
  • new or worse depression
  • new or worse anxiety
  • feeling very agitated or restless
  • panic attacks
  • trouble sleeping (insomnia)
  • new or worse irritability
  • acting aggressive, being angry, or violent
  • acting on dangerous impulses
  • an extreme increase in activity and talking (mania)
  • other unusual changes in behavior or mood

What else do I need to know about antidepressant medicines?

  • Never stop an antidepressant medicine without first talking to your healthcare provider. Stopping an antidepressant medicine suddenly can cause other symptoms.
  • Antidepressants are medicines used to treat depression and other illnesses. It is important to discuss all the risks of treating depression and also the risks of not treating it. Patients and their families or other caregivers should discuss all treatment choices with the healthcare provider, not just the use of antidepressants.
  • Antidepressant medicines have other side effects. Talk to the healthcare provider about the side effects of the medicine prescribed for you or your family member.
  • Avoid getting overheated or dehydrated.
  • Do not drink alcohol while taking Seroquel. It may make some side effects of Seroquel worse.
  • Do not over-exercise.
  • In hot weather, stay inside in a cool place if possible.
  • Stay out of the sun. Do not wear too much or heavy clothing.
  • Drink plenty of water.
  • Antidepressant medicines can interact with other medicines. Know all of the medicines that you or your family member take. Keep a list of all medicines to show the healthcare provider. Do not start new medicines without first checking with your healthcare provider.
  • Not all antidepressant medicines prescribed for children are FDA approved for use in children. Talk to your child’s healthcare provider for more information.
  • High blood sugar (hyperglycemia): High blood sugar can happen if you have diabetes already or if you have never had diabetes. High blood sugar could lead to:
  • Build up of acid in your blood due to ketones (ketoacidosis)
  • Coma
  • Death

Call your doctor if you have any of these symptoms of high blood sugar (hyperglycemia) while taking Seroquel:

  • feel very thirsty
  • need to urinate more than usual
  • feel very hungry
  • feel weak or tired
  • feel sick to your stomach
  • feel confused, or your breath smells fruity

Do not drive, operate machinery, or do other dangerous activities until you know how Seroquel affects you. Seroquel may make you drowsy.

Seroquel Food Interactions

Grapefruit and grapefruit juice may interact with Seroquel and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Inform MD

Before taking Seroquel, tell your healthcare provider about all of your medical conditions and especially if you have or have had:

  • diabetes or high blood sugar in you or your family: your healthcare provider should check your blood sugar before you start quetiapine and also during therapy
  • high levels of total cholesterol, triglycerides or LDL-cholesterol or low levels of HDL- cholesterol
  • low or high blood pressure
  • low white blood cell count
  • cataracts
  • seizures
  • abnormal thyroid tests
  • high prolactin levels
  • heart problems
  • liver problems
  • any other medical condition
  • pregnancy or plans to become pregnant. It is not known if Seroquel will harm your unborn baby
  • breastfeeding or plans to breastfeed

Tell the healthcare provider about all the medicines that you take or recently have taken including prescription medicines, nonprescription medicines, herbal supplements and vitamins.

Seroquel and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Seroquel falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.


Seroquel and Lactation

Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Seroquel can pass into your breast milk. You and your healthcare provider should decide if you will take Seroquel or breastfeed. You should not do both.

Seroquel Usage

Take Seroquel exactly as your healthcare provider tells you to take it. 

Seroquel comes in tablet form and is typically taken twice per day by mouth, with a light meal or without food.

If you feel you need to stop Seroquel, talk with your healthcare provider first. If you suddenly stop taking Seroquel, you may experience side effects such as trouble sleeping or trouble staying asleep (insomnia), nausea, and vomiting.

If you miss a dose, take it as soon as you remember. If it is close to the next dose, skip the missed dose. Just take the next dose at your regular time. Do not take 2 doses at the same time unless your healthcare provider tells you to. If you are not sure about your dosing, call your healthcare provider.

Seroquel Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • side effects

The recommended dose range of Seroquel for the treatment of schizophrenia and bipolar mania is 400-800mg/day.

The recommended dose of Seroquel for bipolar depression is 300 mg/day.

Seroquel Overdose

If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.


Other Requirements

  • Store Seroquel at room temperature, between 59°F to 86°F (15°C to 30°C).
  • Keep Seroquel and all medicines out of the reach of children.

Seroquel FDA Warning


Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks) largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. Seroquel is not approved for the treatment of patients with dementia-related psychosis.


Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of quetiapine or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Seroquel is not approved for use in pediatric patients.