treats high cholesterol in certain patients. It is the second drug approved in a new class of drugs known as PCSK9 inhibitors.

Repatha Overview

Reviewed: August 28, 2015

Repatha is a prescription medication used to lower cholesterol in certain patients. 

Repatha belongs to a new class of drugs called proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors. These work to block a naturally occurring protein called PCSK9 that prevents the liver from removing LDL from the blood.

Repatha is available as an injection. It is injected subcutaneously (under the skin) every other week or monthly.

Common side effects include upper respiratory tract infection, flu, and back pain.

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Repatha Cautionary Labels


Uses of Repatha

Repatha is a prescription medication used to lower cholesterol. Repatha is used along with diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia (HoFH) (an inherited condition that causes high levels of LDL).

It is also approved for patients who have atherosclerotic cardiovascular disease (CVD) such as heart attacks or strokes, who need additional lowering of LDL cholesterol.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.


Repatha Drug Class

Repatha is part of the drug class:

Side Effects of Repatha

Serious side effects have been reported with Repatha. See the “Repatha Precautions” section.

The most common side effects of Repatha include:
  • runny nose
  • sore throat
  • symptoms of the common cold
  • flu or flu-like symptoms
  • back pain
  • redness
  • pain
  • bruising at the injection site.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Repatha. Ask your healthcare provider or pharmacist for more information.

Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Repatha Interactions

No drug interactions have been determined by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Repatha Precautions

Serious side effects have been reported with Repatha including allergic reactions.

Repatha may cause allergic reactions. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including:

  • severe rash
  • redness
  • severe itching
  • a swollen face
  • trouble breathing

Do not use Repatha if you are allergic to Repatha or any of its ingredients. 

Repatha Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Repatha, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before you start using Repatha, tell your healthcare provider about all your medical conditions, including allergies, and if you:

  • are allergic to rubber or latex. The needle covers on the single-use prefilled syringes and within the needle caps on the single-use prefilled SureClick autoinjectors contain dry natural rubber.
  • are pregnant or plan to become pregnant. It is not known if Repatha will harm your unborn baby. Tell your healthcare provider if you become pregnant while taking Repatha.
  • are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will take Repatha or breastfeed. You should not do both without talking to your healthcare provider first.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

Repatha and Pregnancy

There are no well-controlled studies that have been done in pregnant women. Repatha should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

Repatha and Lactation

It is not known if Repatha crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Repatha.

Repatha Usage

Use Repatha exactly as your healthcare provider tells you to use it.

  • Repatha is given as an injection under the skin (subcutaneously), every 2 weeks or 1 time each month.
  • Repatha can be injected under the skin in the abdomen, thigh, or upper arm. Make sure to rotate the injection site. 
  • Repatha comes as a single-use (1 time) pre-filled autoinjector or as a single-use pre-filled syringe. Your healthcare provider will prescribe the type and dose that is best for you.
  • If your healthcare provider prescribes you the (420 mg) monthly dose, you will give yourself 3 separate injections in a row, using a different syringe for each injection. Give all of these injections within 30 minutes.
  • If your healthcare provider decides that you or a caregiver can give the injections of Repatha, you or your caregiver should receive training on the right way to prepare and administer Repatha. Do not try to inject Repatha until you have been shown the right way by your healthcare provider or nurse.
  • Do not inject Repatha together with other injectable medicines at the same injection site.
  • Always check the label your syringe to make sure you have the correct medicine and the correct dose of Repatha before each injection.
  • Prior to use, allow Repatha to warm to room temperature for at least 30 minutes. Do not warm in any other way

If you forget to use Repatha or are not able to take the dose at the regular time, inject your missed dose as soon as you remember, as long as there are more than 7 days until the next scheduled dose. If there are 7 days or less until your next scheduled dose, administer the next dose according to the original schedule. This will put you back on your original schedule. If you are not sure when to take Repatha after a missed dose, ask your healthcare provider or pharmacist.

Do not stop using Repatha without talking with your healthcare provider. If you stop using Repatha, your cholesterol levels can increase.

Repatha Dosage

The recommended dose of Repatha in patients primary hyperlipidemia with heterozygous familial hypercholesterolemia (HoFH) or with established clinical atherosclerotic CVD is either 140 mg every 2 weeks OR 420 mg once monthly. 

The recommended dose of Repatha in patients with heterozygous familial hypercholesterolemia (HoFH) is 420 mg once monthly. Your doctor will monitor your LDL levels 4 to 8 weeks after starting Repatha.

If an every 2 week or once monthly dose is missed, instruct the patient to:

  • Administer Repatha as soon as possible if there are more than 7 days until the next scheduled dose, or,
  • Omit the missed dose and administer the next dose according to the original schedule.

When switching dosage regimens, administer the first dose of the new regimen on the next scheduled date of the prior regimen.

Repatha Overdose

If you take too much Repatha, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store refrigerated at 2° to 8°C (36° to 46°F) in the original carton.
  • Alternatively, Repatha can be kept at room temperature (up to 25°C (77°F)) in the original carton; however, under these conditions, Repatha must be used within 30 days. If not used within the 30 days, discard Repatha.
  • Protect Repatha from direct light and do not expose to temperatures above 25°C (77°F).
  • Keep Repatha all medicines out of the reach of children.