 is a prescription medicine used to treat depression, obsessive compulsive disorder (OCD), and panic disorder. Prozac is a type of drug known as a selective serotonin reuptake inhibitor (SSRI). It works by changing the levels of certain chemicals in the brain that affect your mood.Prozac is available as a capsule and a liquid to be taken by mouth. It is usually taken once or twice daily, with or without food. Common side effects of Prozac include unusual dreams, sexual problems, and loss of appetite. "Pin It")
Prozac OverviewFollow Medication
Prozac (generic: fluoxetine) is a prescription medicine used to treat depression, obsessive compulsive disorder (OCD), and panic disorder. Prozac is a type of drug known as a selective serotonin reuptake inhibitor (SSRI). It works by changing the levels of certain chemicals in the brain that affect your mood.
Uses of Prozac
Prozac is a prescription medicine used to treat the following conditions:
- depression (known medically as Major Depressive Disorder (MDD) or clinical depression)
- Obsessive Compulsive Disorder (OCD)
- Bulimia Nervosa
- Panic Disorder
- Depression associated with Bipolar Disorder, taken with olanzapine (Zyprexa)
- Treatment-Resistant Depression (depression that has not gotten better with at least 2 other treatments), taken with olanzapine (Zyprexa)
Side Effects of Prozac
Prozac may cause serious side effects, including:
- see "Black Box Warning" and "Drug Precautions"
- Problems with blood sugar control. People who have diabetes and take Prozac may have problems with low blood sugar while taking Prozac. High blood sugar can happen when Prozac is stopped. Your healthcare provider may need to change the dose of your diabetes medicines when you start or stop taking Prozac.
- Feelings of anxiousness
- Trouble with sleeping
Common possible side effects in people who take Prozac include:
- unusual dreams
- sexual problems
- loss of appetite, diarrhea, indigestion, nausea or vomiting, weakness, or dry mouth
- flu symptoms
- feeling tired or fatigued
- change in sleep habits
- yawning
- sinus infection or sore throat
- tremor or shaking
- sweating
- feeling anxious or nervous
- hot flashes
- rash
- increased thirst
- abnormal increase in muscle movement or agitation
- nose bleed
- urinating more often
- heavy menstrual periods
- possible slowed growth rate and weight change. Your child’s height and weight should be monitored during treatment with Prozac.
Prozac Interactions
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
- Triptans used to treat migraine headache
- Medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, SSRIs, SNRIs, MAOI’s (including linezolid, an antibiotic), or antipsychotics
- Tramadol
- Over-the-counter supplements such as tryptophan or St. John’s Wort
If you take Prozac, you should not take any other medicines that contain fluoxetine hydrochloride including:
- Symbyax
- Sarafem
- Prozac Weekly
Prozac and some medicines may interact with each other, may not work as well, or may cause serious side effects. Your healthcare provider or pharmacist can tell you if it is safe to take Prozac with your other medicines. Do not start or stop any medicine while taking Prozac without talking to your healthcare provider first.
Prozac Precautions
Prozac and other antidepressant medicines may cause serious side effects, including:
1. Suicidal thoughts or actions:
- Prozac and other antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment or when the dose is changed.
- Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions.
- Watch for these changes and call your healthcare provider right away if you notice:
- New or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe.
- Pay particular attention to such changes when Prozac is started or when the dose is changed.
Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms.
Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency, especially if they are new, worse, or worry you:
- attempts to commit suicide
- acting on dangerous impulses
- acting aggressive or violent
- thoughts about suicide or dying
- new or worse depression
- new or worse anxiety or panic attacks
- feeling agitated, restless, angry or irritable
- trouble sleeping
- an increase in activity or talking more than what is normal for you
- other unusual changes in behavior or mood
Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency. Prozac may be associated with these serious side effects:
2. Serotonin Syndrome or Neuroleptic Malignant Syndrome-like reactions. This condition can be life-threatening and may include:
- agitation, hallucinations, coma or other changes in mental status
- coordination problems or muscle twitching (overactive reflexes)
- racing heartbeat, high or low blood pressure
- sweating or fever
- nausea, vomiting, or diarrhea
- muscle rigidity
3. Severe allergic reactions:
- trouble breathing
- swelling of the face, tongue, eyes or mouth
- rash, itchy welts (hives) or blisters, alone or with fever or joint pain
4. Abnormal bleeding: Prozac and other antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAIDs, like ibuprofen or naproxen), or aspirin.
5. Seizures or convulsions
6. Manic episodes:
- greatly increased energy
- severe trouble sleeping
- racing thoughts
- reckless behavior
- unusually grand ideas
- excessive happiness or irritability
- talking more or faster than usual
7. Changes in appetite or weight: Children and adolescents should have height and weight monitored during treatment.
8. Low salt (sodium) levels in the blood: Elderly people may be at greater risk for this. Symptoms may include:
- headache
- weakness or feeling unsteady
- confusion, problems concentrating or thinking or memory problems
Do not stop Prozac without first talking to your healthcare provider. Stopping Prozac too quickly may cause serious symptoms including:
- anxiety, irritability, high or low mood, feeling restless or changes in sleep habits
- headache, sweating, nausea, dizziness
- electric shock-like sensations, shaking, confusion
Do not take Prozac if you:
- are allergic to fluoxetine hydrochloride or any of the ingredients in Prozac.
- take a Monoamine Oxidase Inhibitor (MAOI).
- Do not take an MAOI within 5 weeks of stopping Prozac.
- Do not start Prozac if you stopped taking an MAOI in the last 2 weeks. People who take Prozac close in time to an MAOI may have serious or even lifethreatening side effects. Get medical help right away if you have any of these symptoms:
- high fever
- uncontrolled muscle spasms
- stiff muscles
- rapid changes in heart rate or blood pressure
- confusion
- loss of consciousness (pass out)
- take Mellaril (thioridazine). Do not take Mellaril within 5 weeks of stopping Prozac because this can cause serious heart rhythm problems or sudden death.
- take the antipsychotic medicine pimozide (Orap) because this can cause serious heart problems.
Prozac Food Interactions
Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Prozac there are no specific foods that you must exclude from your diet when receiving Prozac.
Inform MD
Before starting Prozac, tell your healthcare provider if you:
- Are taking certain drugs or treatments such as:
- Triptans used to treat migraine headache
- Medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, SSRIs, SNRIs, MAOI’s (including linezolid, an antibiotic), or antipsychotics
- Tramadol
- Over-the-counter supplements such as tryptophan or St. John’s Wort
- Electroconvulsive therapy (ECT)
- have liver problems
- have kidney problems
- have heart problems
- have or had seizures or convulsions
- have bipolar disorder or mania
- have low sodium levels in your blood
- have a history of a stroke
- have high blood pressure
- have or had bleeding problems
- are pregnant or plan to become pregnant. It is not known if Prozac will harm your unborn baby. Talk to your healthcare provider about the benefits and risks of treating depression during pregnancy.
- are breastfeeding or plan to breastfeed. Some Prozac may pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking Prozac.
- Symbyax
- Sarafem
- Prozac Weekly
Prozac and Pregnancy
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if Prozac will harm your unborn baby. Talk to your healthcare provider about the benefits and risks of treating depression during pregnancy.
Prozac and Lactation
Tell your doctor if you are breastfeeding or plan to breastfeed. Some Prozac may pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking Prozac.
Prozac Usage
Take Prozac exactly as prescribed. Your healthcare provider may need to change the dose of Prozac until it is the right dose for you.
- Prozac may be taken with or without food.
- If you miss a dose of Prozac, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Prozac at the same time.
- If you take too much Prozac, call your healthcare provider or poison control center right away, or get emergency treatment.
Prozac Dosage
Take Prozac exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you. The dosage of Prozac must be individualized. Do not take more or less of it or take it more often than prescribed by your doctor. Your doctor may start you on a low dose of Prozac and gradually increase your dose. It may take more than 4 weeks before you feel the full benefit of Prozac. Do not stop taking Prozac until you talk to your doctor. If you need to stop taking Prozac, your doctor will probably decrease your dose gradually.
Prozac adult doses range from 20 mg to 80 mg daily.
Prozac Overdose
If you take too much Prozac call your local Poison Control Center or seek emergency medical attention right away.
Forms of Prozac
Prozac capsules are available in 10 mg, 20 mg, and 40 mg strengths.
Prozac Weekly is available in a 90 mg strength capsule.
Active ingredient: fluoxetine
- Prozac pulvules: starch, gelatin, silicone, titanium dioxide, iron oxide, and other inactive ingredients. The 10 and 20 mg Pulvules also contain FD&C Blue No. 1, and the 40 mg Pulvules also contains FD&C Blue No. 1 and FD&C Yellow No. 6.
- Prozac Weekly capsules: D&C Yellow No. 10, FD&C Blue No. 2, gelatin, hypromellose, hypromellose acetate succinate, sodium lauryl sulfate, sucrose, sugar spheres, talc, titanium oxide, triethyl citrate, and other inactive ingredients.
Other Requirements
- Store Prozac at room temperature between 59°F and 86°F (15°C to 30°C).
- Keep Prozac away from light.
- Keep Prozac bottle closed tightly.
- Keep Prozac and all medicines out of the reach of children.
Prozac FDA Warning
WARNING: SUICIDALITY AND ANTIDEPRESSANT DRUGS
Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of Major Depressive Disorder (MDD) and other psychiatric disorders. Anyone considering the use of Prozac or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Prozac is approved for use in pediatric patients with MDD and Obsessive Compulsive Disorder (OCD)
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