Procarbazine

Procarbazine treats certain types of Hodgkin's disease. Avoid eating foods containing high amounts of tyramine. Do not drink alcoholic beverages (including beer and wine) while taking procarbazine.

Procarbazine Overview

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Procarbazine is a prescription medication used to treat certain types of Hodgkins disease. Procarbazine belongs to a group of drugs called alkylating agents. These work by slowing or stopping the growth of cancer cells in your body.

Procarbazine comes as a capsule to take by mouth. It is usually taken one or more times a day, with or without food.

Common side effects include nausea, vomiting, and low blood counts.

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  • Other
  • Brain Neoplasms
  • Hodgkin Disease
  • Lung Neoplasms
  • Lymphoma, Non-hodgkin
  • Melanoma
  • Multiple Myeloma

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Procarbazine Cautionary Labels

precautionsprecautionsprecautionsprecautionsprecautionsprecautions

Uses of Procarbazine

Procarbazine is a prescription medication used in combination with other medications to treat certain types of Hodgkins disease. Hodgkins disease consists of different types of cancer that begin in a type of white blood cells that normally fights infection.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
 

Procarbazine Brand Names

Procarbazine may be found in some form under the following brand names:

Procarbazine Drug Class

Procarbazine is part of the drug class:

Side Effects of Procarbazine

Common side effects include the following:

  • nausea
  • vomiting
  • loss of appetite
  • constipation
  • stomach pain
  • dryness of mouth
  • changes in skin color
  • hair loss
  • difficulty falling asleep or staying asleep
  • headache
  • bone, joint, or muscle pain
  • increased urination

This is not a complete list of this medication’s side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Procarbazine Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • certain antidepressants including amitriptyline (Elavil) and imipramine (Tofranil)
  • medications for asthma
  • medications for allergies or hay fever
  • medications containing alcohol (cough and cold products, such as Nyquil, and other liquid products)
  • nasal decongestants, including nose drops and sprays
  • barbiturate medications such as phenobarbital
  • medications for high blood pressure
  • medications for nausea or mental illness
  • opioid (narcotic) medications for pain
  • sedatives or sleeping pills
  • alcohol
  • tobacco

This is not a complete list of procarbazine drug interactions. Ask your doctor or pharmacist for more information.

Procarbazine Precautions

Somes serious side effects of procarbazine include:

  • sores in the mouth and throat
  • severe or ongoing diarrhea
  • pain, burning, numbness, pricking, or tingling in the hands or feet or on the skin
  • uncontrollable shaking of a part of your body
  • confusion
  • hallucinating (seeing things or hearing voices that do not exist)
  • seizures
  • vision changes
  • fainting
  • dizziness
  • fast or irregular heartbeat
  • fever, sore throat, chills, or other signs of infection
  • unusual bruising or bleeding
  • black, tarry stools
  • red urine
  • hives
  • rash
  • itching
  • difficulty breathing or swallowing
  • yellowing of the skin or eyes

Seek medical help if you experience any of these side effects.

Procarbazine may increase the risk that you will develop other cancers.

Do not take procabazine if you

  • are allergic to this medication or its inactive ingredients
  • have poor bone marrow health

Procarbazine Food Interactions

Tyramine is a naturally occurring compound found in some cheeses and other foods that may cause dangerously high blood pressure in people taking procarbazine:

  • You should avoid eating very large amounts of foods containing high amounts of tyramine such as:
    • cheese (particularly strong or aged varieties)
    • sour cream
    • Chianti wine
    • sherry
    • beer (including non-alcoholic beer)
    • liqueurs
    • pickled herring
    • anchovies
    • caviar
    • liver
    • canned figs
    • raisins
    • bananas
    • avocados (particularly if overripe)
    • chocolate
    • soy sauce
    • sauerkraut
    • the pods of broad beans (fava beans)
    • yeast extracts
    • yogurt
    • meat extracts
    • meat prepared with tenderizers
    • dry sausage

Some of the signs and symptoms of dangerously high blood pressure (hypertensive crisis) are:

  • severe headache
  • vision problems
  • confusion
  • stupor (mental numbness)
  • coma
  • seizures
  • chest pain
  • unexplained nausea or vomiting
  • stroke-like symptoms (sudden numbness or weakness - especially on one side of the body)

Get emergency medical help if you experience these symptoms.

Inform MD

Before taking procarbazine,

  • tell your doctor and pharmacist if you are allergic to procarbazine, any other medications, or any of the ingredients in procarbazine capsules. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
  • tell your doctor if you have received radiation therapy or other chemotherapy within the last 4 weeks.
  • tell your doctor if you have or have ever had kidney or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should not become pregnant or breast-feed while you are taking procarbazine. If you become pregnant while receiving procarbazine, call your doctor. Procarbazine may harm the fetus.
  • know that you should not drink alcoholic beverages (including beer and wine) while taking this drug. Alcohol may cause an upset stomach, vomiting, stomach cramps, headaches, sweating, and flushing (redness of the face).
  • tell your doctor if you use tobacco products. Smoking may increase the risk that you will develop other cancers. You should stop smoking.

Procarbazine and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category D. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child. You should avoid becoming pregnant while taking procarbazine.

Procarbazine and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if procarbazine crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using procarbazine.

Procarbazine Usage

  • Take procarbazine exactly as directed.
  • Procarbazine comes as a capsule to take by mouth. It is usually taken one or more times a day.
  • The length of treatment depends on well your body responds to them and the type of cancer you have.
  • Take procarbazine at around the same time(s) every day.
  • Do not take more or less of it or take it more often than prescribed by your doctor.
  • Your doctor may adjust your dose of procarbazine or stop your treatment for a period of time depending on your response to treatment and any side effects that you experience.
  • Talk to your doctor about how you are feeling during your treatment.

Procarbazine Dosage

Adults

  • Single or divided doses of 2 to 4 mg/kg/day for the first week are recommended.
  • Daily dosage should then be at 4 to 6 mg/kg/day until maximum response is obtained or until toxicity occurs.
  • When maximum response is obtained, the dose may be kept at 1 to 2 mg/kg/day.

Pediatric Patients:

  • Very close clinical monitoring is mandatory.
  • Undue toxicity, evidenced by tremors, coma and convulsions, has occurred in a few cases. Dosage, therefore, should be individualized.
  • The following dosage schedule is provided as a guideline only:
    • 50 mg/m2 of body surface area (BSA) per day is recommended for the first week.
    • Dosage should then be kept at 100 mg/m2 of body surface area (BSA) per day until maximum response is obtained or until toxicity occurs.
    • When maximum response is reached, the dose may be kept at 50 mg/m2 of body surface area (BSA) per day

Procarbazine Overdose

If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If this medication is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Store at 59° to 86°F (15° to 30°C).
  • Keep this and all medications out of the reach of children.

Procarbazine FDA Warning

It is recommended that procarbazine be given only by or under the supervision of a physician experienced in the use of potent antineoplastic drugs. Adequate clinical and laboratory facilities should be available to patients for proper monitoring of treatment.