Xeloda

Xeloda is a prescription medication used to treat breast cancer and cancer of the colon or rectum. Xeloda belongs to a group of drugs called antimetabolites which work by interfering with DNA production, stopping cells from multiplying.

This medication comes in tablet form and is usually taken twice daily, within 30 minutes after the end of a meal.

Swallow Xeloda tablets whole. Do not cut or crush tablets.

Common side effects include diarrhea, nausea, vomiting, and mouth sores.

WARNING: XELODA-WARFARIN INTERACTION

Xeloda-Warfarin Interaction: Patients receiving concomitant Xeloda and oral coumarin-derivative anticoagulant therapy should have their anticoagulant response (INR or prothrombin time) monitored frequently in order to adjust the anticoagulant dose accordingly. A clinically important Xeloda-Warfarin drug interaction was demonstrated in a clinical pharmacology trial. Altered coagulation parameters and/or bleeding, including death, have been reported in patients taking Xeloda concomitantly with coumarin-derivative anticoagulants such as warfarin and phenprocoumon. Postmarketing reports have shown clinically significant increases in prothrombin time (PT) and INR in patients who were stabilized on anticoagulants at the time Xeloda was introduced. These events occurred within several days and up to several months after initiating Xeloda therapy and, in a few cases, within 1 month after stopping Xeloda. These events occurred in patients with and without liver metastases. Age greater than 60 and a diagnosis of cancer independently predispose patients to an increased risk of coagulopathy.

Breast Cancer Female [1] Cancer [2] Colon Cancer [3] Rectal Cancer [4]

Reviewed by:

Anyssa Garza, PharmD [5]

Citation:

"Xeloda", DailyMed: Current Medication Information; U.S. National Library of Medicine [6] "Capecitabine", DailyMed: Current Medication Information; U.S. National Library of Medicine [7]

http://www.rxwiki.com/xeloda [8]

Capecitabine [9]

Rx Company Link:

Genentech, Inc. [10]

RxNorm ATC Ref:

Pyrimidine analogues [11]

Contributor:

Anyssa Garza, PharmD [5] Teresa Brucker, Pharm.D [12] Beth Bolt, RPh [13] Eric Ho, Pharm.D [14]

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Xeloda treats certain types of cancer. It can cause diarrhea and mouth sores. Tell your doctor if you notice pain, swelling or redness of your hands or feet.

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