Lotronex

Lotronex is a prescription medication used to treat women with the symptoms of severe irritable bowel syndrome (IBS) including diarrhea, pain, cramps, and the urgent need to have bowel movements. Lotronex belongs to a group of drugs called serotonin agonists which work by slowing the movement of stool through the intestines.

This medication comes in tablet form and is usually taken twice daily, with or without food.

Common side effects of Lotronex include constipation and nausea.

SERIOUS GASTROINTESTINAL ADVERSE REACTIONS

Infrequent but serious gastrointestinal adverse reactions have been reported with the use of this medication. These events, including ischemic colitis and serious complications of constipation, have resulted in hospitalization and, rarely, blood transfusion, surgery, and death.

The Prescribing Program for Lotronex was implemented to help reduce risks or serious gastrointestinal adverse reactions. Only prescribers who have enrolled in the Prometheus Prescribing Program for Lotronex should prescribe this medication.

This medication is indicated only for women with severe diarrhea-predominant irritable bowel syndrome (IBS) who have not responded adequately to conventional therapy. Before receiving the initial prescription for this medication, the patient must read and sign the Patient Acknowledgement Form for Lotronex.

Discontinue this medication immediately in patients who develop constipation or symptoms of ischemic colitis. Do not resume this medication in patients who develop ischemic colitis. Patients should immediately report constipation or symptoms of ischemic colitis to their prescriber. Patients who have constipation should immediately contact their prescriber if the constipation does not resolve after this medication is discontinued. Patients with resolved constipation should resume this medication only on the advice of their treating prescriber.

Irritable Bowel Syndrome [1] Gastrointestinal [2] Diarrhea [3]

Female [4]

Citation:

"Lotronex", DailyMed: Current Medication Information; U.S. National Library of Medicine [5]

http://www.rxwiki.com/lotronex [6]

Alosetron [7]

Rx Company Link:

Prometheus Laboratories Inc. [8]

RxNorm ATC Ref:

Serotonin receptor antagonists [9]

Contributor:

Teresa Brucker, Pharm.D [10] Anyssa Garza, PharmD [11] Walker Winn [12] Beau Faulkner [13]

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Lotronex treats irritable bowel syndrome (IBS) in women whose main problem is diarrhea. May cause constipation. Tell your doctor if you are taking other medications to treat diarrhea.

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