Korlym is a prescription medication used to treat high blood sugar caused by high cortisol levels in the blood in adults with Cushing's syndrome and type 2 diabetes or glucose intolerance. Korlym belongs to a group of drugs called cortisol receptor blockers, which block the actions of cortisol to lower blood sugar levels.
This medication comes in tablet form and is taken once a day, with food.
Common side effects include nausea, fatigue, and headache. Do not drink grapefruit juice while taking Korlym.
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WARNING: TERMINATION OF PREGNANCY
Korlym is a potent antagonist of progesterone and cortisol via the progesterone and glucocorticoid (GR-II) receptors, respectively. The antiprogestational effects will result in the termination of pregnancy. Pregnancy must therefore be excluded before the initiation of treatment with Korlym and prevented during treatment and for one month after stopping treatment by the use of a non-hormonal medically acceptable method of contraception unless the patient has had a surgical sterilization, in which case no additional contraception is needed. Pregnancy must also be excluded if treatment is interrupted for more than 14 days in females of reproductive potential.
