relieves symptoms associated with menopause. Re-evaluate with your doctor every 3 to 6 months about the dose you are taking and whether you still need this medication.

Prefest Overview


Prefest is a prescription medication used after menopause to reduce moderate to severe hot flashes, treat moderate to severe menopausal changes in and around the vagina, and help reduce your chances of getting osteoporosis (thin weak bones). Prefest contains two hormones, estradiol and norgestimate, and belongs to a group of drugs called estrogen and progestin combinations. Prefest works as a hormone replacement to relieve issues caused by hormonal changes. 

Prefest comes in tablet form and is usually taken once daily, with or without food. 

Common side effects of Prefest include headache, breast pain, and irregular vaginal bleeding or spotting.

Patient Ratings for Prefest

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Prefest Cautionary Labels



Estradiol and Norgestimate

For more information on this medication choose from the list of selections below.

Prefest Drug Class

Prefest is part of the drug class:

Prefest FDA Warning