Portrazza

Portrazza treats advanced lung cancer. It is used with two other chemotherapies.

Portrazza Overview

Reviewed: November 24, 2015
Updated: 

Portrazza is a prescription medication, used with two other chemotherapy medications, to treat advanced (metastatic) squamous non-small cell lung cancer (NSCLC).

It belongs to a group of drugs called monoclonal antibodies. These drugs work to kill cancer cells. 

This medication is available as a solution to be given into the vein (IV) by a healthcare professional. 

Common side effects include skin rash and magnesium deficiency (hypomagnesemia). 

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Portrazza Cautionary Labels

precautionsprecautionsprecautionsprecautions

Uses of Portrazza

Portrazza is a prescription medication used with two other chemotherapy medications to treat advanced (metastatic) squamous non-small cell lung cancer (NSCLC) in patients who have not previously received medication specifically for treating their advanced lung cancer.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

 

Manufacturer

Portrazza Drug Class

Portrazza is part of the drug class:

Side Effects of Portrazza

Serious side effects have been reported with Portrazza. See the "Portrazza Precautions" section.

Common side effects of Portrazza include the following:

  • low magnesium levels and/or other electrolytes (calcium, potassium, and phosphate) in the blood
  • rash
  • vomiting
  • diarrhea

This is not a complete list of Portrazza side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portrazza Interactions

No drug interactions have been determined by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Portrazza Precautions

Serious side effects have been reported with Portrazza including the following:

  • blood clots. The risk of blood clots may be higher if you already had a blood clot in the past. Your doctor will observe you and stop your treatment if you develop a serious or life-threatening blood clot.
  • skin reactions. These reactions may include a rash, itchy or dry skin, cracks in the skin, red and swollen skin, and a skin infection around the fingernails or toenails. Skin reactions usually begin during the first 2 weeks of treatment and get better about 4 months after they started. Your doctor may change your dose of Portrazza if you experience a skin reaction. Time in the sun may worsen skin reactions so it is important to limit exposure with protective clothing and sunscreen.
  • allergic reactions. Portrazza can cause allergic reactions in some people, generally during the first or second dose. Symptoms can include trouble breathing, wheezing, fever, and chills. Your healthcare provider will watch for signs of allergic reactions during the infusion. You may receive medicine before your Portrazza infusion to prevent these reactions.
  • harmful effects to unborn babies. Portrazza can harm your unborn baby. You should avoid getting pregnant and use adequate birth control while receiving Portrazza and for at least 3 months after stopping the medication.

Do not take Portrazza if you are allergic to the medicine or to any of its ingredients.

Portrazza Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Portrazza, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Portrazza, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Portrazza or to any of its ingredients
  • have a history of heart problems
  • have a history of high blood pressure
  • have a history of lung problems (COPD)
  • have or are at high risk for blood clots
  • are pregnant or may become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Portrazza and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

Portrazza may harm your unborn baby. You should avoid getting pregnant and use adequate birth control while receiving Portrazza and for at least 3 months after stopping the medication.

Portrazza and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Portrazza crosses into human milk. You should not breastfeed while receiving Portrazza and for at least 3 months after stopping the medication.

Portrazza Usage

Take Portrazza exactly as prescribed.

This medication is available as a solution to be given into the vein (IV) by a healthcare professional.

Your doctor may also give you other medications before your Portrazza infusion to help manage possible side effects.

 

Portrazza Dosage

Take this medication exactly as prescribed by your doctor.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your weight
  • your height
  • your age
  • your gender

Portrazza is given as an intravenous (IV) infusion through a vein. You will take Portrazza with 2 chemotherapy medications called gemcitabine and cisplatin.

One cycle of treatment takes 21 days and infusions are given on day 1 and day 8, which can continue for up to 6 cycles, or about 18 weeks as long as your treatment is working and you can tolerate it. 

If the treatment is still working and you are able to tolerate it, you may continue to receive Portrazza without chemotherapy on days 1 and 8 of each 21 day cycle for as long as your doctor recommends.

Portrazza Overdose

If Portrazza is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Portrazza FDA Warning

WARNING: CARDIOPULMONARY ARREST and HYPOMAGNESEMIA

  • Cardiopulmonary arrest and/or sudden death occurred in 3.0% of patients treated with PORTRAZZA in combination with gemcitabine and cisplatin. Closely monitor serum electrolytes, including serum magnesium, potassium, and calcium, with aggressive replacement when warranted during and after PORTRAZZA administration [see Warnings and Precautions].

  • Hypomagnesemia occurred in 83% of patients receiving PORTRAZZA in combination with gemcitabine and cisplatin, and was severe in 20% of patients. Monitor patients for hypomagnesemia, hypocalcemia, and hypokalemia prior to each dose of PORTRAZZA during treatment and for at least 8 weeks following completion of PORTRAZZA. Withhold PORTRAZZA for Grade 3 or 4 electrolyte abnormalities. Replete electrolytes as medically appropriate.