Plavix

Plavix prevents blood clots from forming in patients who have had a heart attack or stroke. Report any unusual bleeding to your physician.

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Plavix Overview

Reviewed: July 6, 2012
Updated: 

Plavix is a prescription medication used to prevent blood clots in people who have recently been hospitalized with chest pain, or for people who have recently had a heart attack or stroke. Plavix belongs to a group of drugs called antiplatelets, which help prevent harmful blood clots from forming in the body.

This medication comes in tablet form and is taken once a day, with or without food.

Common side effects of Plavix include bleeding, headache, dizziness, and nausea.

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Plavix Cautionary Labels

precautionsprecautionsprecautionsprecautionsprecautionsprecautions

Uses of Plavix

Plavix is a prescription medication used to prevent blood clots in people who have recently been hospitalized with chest pains, or for people who have recently had a heart attack or stroke. It is also used in people with certain heart and blood vessel disorders.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Plavix Drug Class

Plavix is part of the drug class:

Side Effects of Plavix

Plavix can cause serious side effects including:

  • See "Drug Precautions" section
  • A blood clotting problem called Thrombotic Thrombocytopenic Purpura (TTP). TTP can happen with Plavix, sometimes after a short time (less than 2 weeks). TTP is a blood clotting problem where blood clots form in blood vessels; and can happen anywhere in the body. TTP needs to be treated in a hospital right away, because it may cause death. Get medical help right away if you have any of these symptoms and they can not be explained by another medical condition:
    • purplish spots (called purpura) on the skin or in the mouth (mucous membranes) due to bleeding under the skin
    • your skin or the whites of your eyes are yellow (jaundice)
    • you feel tired or weak
    • your skin looks very pale
    • fever
    • fast heart rate or feeling short of breath
    • headache
    • speech changes
    • confusion
    • coma
    • stroke
    • seizure
    • low amount of urine, or urine that is pink or has blood in it
    • stomach area (abdominal) pain
    • nausea, vomiting, or diarrhea
    • vision changes

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Plavix. For more information, ask your doctor or pharmacist.

Plavix Interactions

Tell your doctor about all the medicines you take, including prescription, non-prescription medicines, vitamins and herbal supplements.

Plavix may affect the way other medicines work, and other medicines may affect how Plavix works. 

Taking Plavix with certain other medicines may increase your risk of bleeding. Especially tell your doctor if you take:

  • aspirin, especially if you have had a stroke. Always talk to your doctor about whether you should take aspirin along with Plavix to treat your condition.
  • Non-steroidal anti-inflammatory drugs (NSAIDs). Ask your doctor or pharmacist for a list of NSAID medicines if you are not sure.
  • warfarin (Coumadin, Jantoven)

Know the medicines you take. Keep a list of them to show your doctor or pharmacist when you get a new medicine.

Plavix Precautions

Plavix may not work as well in people who:

  • have certain genetic factors that affect how the body breaks down Plavix. Your doctor may do genetic tests to make sure Plavix is right for you.
  • take certain medicines, especially omeprazole (Prilosec) or esomeprazole (Nexium). Your doctor may change the medicine you take for stomach acid problems while you take Plavix.

Plavix can cause bleeding which can be serious and can sometimes lead to death. Plavix is a blood thinner medicine that lowers the chance of blood clots forming in your body. While you take Plavix:

  • you may bruise and bleed more easily
  • you are more likely to have nose bleeds
  • it will take longer for any bleeding to stop

Call your doctor right away if you have any of these signs or symptoms of bleeding:

  • unexpected bleeding or bleeding that lasts a long time
  • blood in your urine (pink, red or brown urine)
  • red or black stools (looks like tar)
  • bruises that happen without a known cause or get larger
  • cough up blood or blood clots
  • vomit blood or your vomit looks like coffee grounds

Do not stop taking Plavix without talking to the doctor who prescribes it for you. People who are treated with a stent, and stop taking Plavix too soon, have a higher risk of getting a blood clot on the stent, having a heart attack, or dying. If you must stop Plavix because of bleeding, your risk of a heart attack may be higher.

Do not take Plavix if you:

  • currently have a condition that causes bleeding, such as a stomach ulcer
  • are allergic to Plavix or other ingredients in Plavix tablets.

Plavix Food Interactions

Grapefruit and grapefruit juice may interact with Plavix and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

 

Inform MD

Before you take Plavix , tell your doctor if you:

  • have a history of bowel (gastrointestinal) or stomach ulcers
  • have a history of bleeding problems
  • plan to have surgery or a dental procedure. 
  • are pregnant or plan to become pregnant. 
  • are breastfeeding or plan to breastfeed. 

Tell all of your doctors and your dentist that you are taking Plavix. They should talk to the doctor who prescribed Plavix for you before you have any surgery or invasive procedure.

Tell your doctor about all the medicines you take, including prescription, non-prescription medicines, vitamins and herbal supplements.

Plavix and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant. It is not known if Plavix will harm your unborn baby.

 

Plavix and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if Plavix passes into your breast milk. You and your doctor should decide if you will take Plavix or breastfeed. You should not do both without talking to your doctor.

 

Plavix Usage

  • Take Plavix exactly as your doctor tells you.
  • Do not change your dose or stop taking Plavix without talking to your doctor first. Stopping Plavix may increase your risk of heart attack or stroke.
  • Take Plavix with aspirin as instructed by your doctor.
  • You can take Plavix with or without food.
  • If you miss a dose, take Plavix as soon as you remember. If it is almost time for your next dose, skip the missed dose. Take the next dose at your regular time. Do not take 2 doses of Plavix at the same time unless your doctor tells you to.
  • If you take too much Plavix, call your doctor or go to the nearest emergency room right away.
  • Talk with your doctor about stopping your Plavix before you have surgery. Your doctor may tell you to stop taking Plavix at least 5 days before you have surgery to avoid excessive bleeding during surgery.

Plavix Dosage

The recommended daily dose of Plavix is 75 mg once daily orally, with or without food.

 

Plavix Overdose

If you take too much Plavix call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If Plavix is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Store Plavix  at 59°F to 86°F (15°C to 30°C).

Keep Plavix and all medicines out of the reach of children.

Plavix FDA Warning

WARNING: DIMINISHED EFFECTIVENESS IN POOR METABOLIZERS  

The effectiveness of Plavix is dependent on its activation to an active metabolite by the cytochrome P450 (CYP) system, principally CYP2C19. Plavix at recommended doses forms less of that metabolite and has a smaller effect on platelet function in patients who are CYP2C19 poor metabolizers. Poor metabolizers with acute coronary syndrome or undergoing percutaneous coronary intervention treated with Plavix at recommended doses exhibit higher cardiovascular event rates than do patients with normal CYP2C19 function. Tests are available to identify a patient's CYP2C19 genotype; these tests can be used as an aid in determining therapeutic strategy. Consider alternative treatment or treatment strategies in patients identified as CYP2C19 poor metabolizers.