Imprint: P 20
Pantoprazole is a prescription medication used to treat gastroesophageal reflux disease and Zollinger-Ellison Syndrome. Pantoprazole belongs to a group of drugs called proton pump inhibitors. These work by decreasing the amount of acid made in the stomach.
This medication comes in tablet and oral (by mouth) suspension form. It is usually taken once or twice daily, with or without food.
This medication is also available in an injectable form to be given directly into a vein (IV) by a healthcare professional.
Common side effects of pantoprazole include headache, diarrhea, and nausea.
Uses of Pantoprazole
Pantoprazole is a prescription medication used for:
- erosive esophagitis (damage to the esophagus caused by stomach acid) caused by gastroesophageal reflux disease (GERD)
- Zollinger-Ellison Syndrome (a condition in which the stomach makes too much acid)
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Pantoprazole Brand Names
Pantoprazole may be found in some form under the following brand names:
Pantoprazole Drug Class
Pantoprazole is part of the drug class:
Side Effects of Pantoprazole
Pantoprazole can cause serious side effects including:
- Stomach lining weakening with long-term use
- Vitamin B-12 deficiency
- Serious allergic reactions. Tell your doctor if you get any of the following symptoms with pantoprazole
- face swelling
- throat tightness
- difficult breathing
Your doctor may stop pantoprazole if these symptoms happen.
The most common side effects with pantoprazole in adults include:
- Stomach pain
- Pain in your joints
The most common side effects with pantoprazole in children include:
- Upper respiratory infection
- Stomach pain
People who are taking multiple daily doses of proton pump inhibitor medicines for a long period of time may have an increased risk of fractures of the hip, wrist or spine.
Tell your doctor about any side effects that bother you or that do not go away.
These are not all the possible side effects with pantoprazole. Talk with your doctor or pharmacist if you have any questions about side effects. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Tell your doctor about all of the medicines you take, including prescription and non-prescription drugs, vitamins and herbal supplements. Pantoprazole may affect how other medicines work, and other medicines may affect how pantoprazole works. Especially tell your doctor if you take:
- Warfarin (Coumadin, Athrombin-K, Jantoven, Panwarfin)
- Ketoconazole (Nizoral)
- Atazanavir (Reyataz), Nelfinavir (Viracept)
- Iron supplements
- Ampicillin antibiotics
Ask your doctor if you are not sure if any of your medicines are the kind listed above.
Do not take pantoprazole if you are:
- allergic to any of the ingredients in pantoprazole delayed-release tablets.
- allergic to any proton pump inhibitor (PPI). If you do not know if your medicines are PPIs, please ask your doctor.
Pantoprazole Food Interactions
Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Pantoprazole there are no specific foods that you must exclude from your diet when receiving Pantoprazole.
Before taking pantoprazole, tell your doctor about all your medical conditions, including if you are:
- pregnant, think you may be pregnant, or are planning to become pregnant.
- breastfeeding or planning to breastfeed.
Tell your doctor about all of the medicines you take, including prescription and non-prescription drugs, vitamins and herbal supplements.
Pantoprazole and Pregnancy
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
Pantoprazole falls into category B. There are no well-done studies that have been done in humans with pantoprazole. But in animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.
Pantoprazole and Lactation
Tell your doctor if you are breastfeeding or plan to breastfeed.
Pantoprazole has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from pantoprazole, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.
- Take pantoprazole exactly as prescribed by your doctor.
- Do not change your dose or stop pantoprazole without talking to your doctor.
- If you forget to take a dose of pantoprazole, take it as soon as you remember. If it is almost time for your next dose, do not take the missed dose. Take the next dose at your regular time. Do not take two doses to try to make up for a missed dose.
- You can take pantoprazole tablets with food or on an empty stomach.
- Swallow pantoprazole tablets whole.
- If you have trouble swallowing a pantoprazole 40 mg tablet, you can take two 20 mg tablets instead.
- Do not split, chew, or crush pantoprazole sodium tablets.
- Pantoprazole oral suspension should only be taken with applesauce or apple juice 30 minutes before a meal.
- Pantoprazole should not be taken in or with water or other liquids, or with other foods other than those described below.
- Pantoprazole oral suspension should not be chewed or crushed.
- Pantoprazole oral suspension packet should not be divided to make a smaller dose.
Directions for use with applesauce:
- Open packet.
- Sprinkle granules on one teaspoonful of applesauce. Do not use any other foods. Do not crush or chew the granules.
- Take within 10 minutes of putting the granules into the teaspoon of applesauce.
- Take sips of water to make sure the granules are washed down into the stomach. Repeat water sips as necessary.
Directions for use with apple juice:
- Open packet.
- Empty granules into a small cup or teaspoon with one teaspoonful of apple juice.
- Stir the mix for 5 seconds (granules will not break up) and swallow it right away.
- To make sure that the entire dose is taken, rinse the container once or twice with apple juice to get out any leftover granules. Swallow the apple juice right away.
Nasogastric Tube or Gastrostomy Tube Administration
For people who have a nasogastric (NG) tube or gastrostomy tube in place, pantoprazole oral suspension can be given as follows:
- Remove the plunger from the barrel of a 2 ounce (60 mL) catheter-tip syringe. Throw away the plunger.
- Connect the catheter tip of the syringe to a 16 French (or larger) tube.
- Hold the syringe attached to the tubing as high as possible while giving pantoprazole oral suspension to prevent any bending of the tubing.
- Empty the contents of the packet into the barrel of the syringe.
- Add 10 mL (2 teaspoonfuls) of apple juice and gently tap or shake the barrel of the syringe to help empty the syringe.
- Do this again at least two more times using the same amount of apple juice (10 mL or 2 teaspoonfuls) each time. No granules should be left in the syringe.
- This medication is also available in an injectable form to be given directly into a vein (IV) by a healthcare professional.
Take pantoprazole exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
- For short-term treatment of erosive esophagitis linked with GERD, the adult dose is 40 mg once daily for up to 8 weeks.
- For maintenance of healing of erosive esophagitis, the adult 40 mg once daily.
- For hypersecretory conditions such as Zollinger-Ellison Syndrome, the adult dose is 40 mg twice daily.
If you take too much pantoprazole sodium, call your doctor right away.
- Store pantoprazole at room temperature between 59° to 86°F (15° to 30°C).
- Keep pantoprazole and all medicines out of the reach of children.
Related Clinical Trials
- The CONQUEST-Study. Evaluation of Clinical Endpoints for Treatment-induced Changes in GERD-related Symptoms (BY1023/NL511)
- Efficacy of Pantoprazole 20/40 mg Once Daily (od) in Patients Older Than 12 Years Who Have Gastrointestinal Symptoms of Reflux Disease
- Pantoprazole 20/40 mg in the Treatment of Symptomatic Reflux Disease With Focus on Sleep Disorders
- The Clinical Significance of Acid Rebound in Functional Dyspepsia
- Esomeprazole Versus Pantoprazole to Prevent Peptic Ulcer Rebleeding
- Study Assessing the Interaction of Pantoprazole With Cladribine in Subjects With Multiple Sclerosis
- Determination of a Questionnaire After Treatment With Pantoprazole at Full Dose and Half Dose in Adult Patients With Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/UK-506)
- "Pharmacodynamic Comparison of Omeprazole Versus Pantoprazole on Platelet Reactivity in Patients With Acute Coronary Syndromes on Dual Antiplatelet Therapy With New P2Y12 Inhibitors" -Trial dOPPLER-
- Symptom Assessment in Adult Patients With Erosive GERD (Gastroesophageal Reflux Disease) or enGERD (Endoscopic-negative GERD) After Treatment With Pantoprazole (BY1023/M3-343)
- Pharmacokinetics of Pantoprazole and CYP2C19 Activity in Children and Adolescents With GERD: A Pilot Study
- Intravenous (IV) Pantoprazole in Erosive Esophagitis
- PPI and Clopidogrel Response
- Efficacy of Pantoprazole in Patients Older Than 18 Years Who Have Symptoms of Non-erosive Reflux or Gastroesophageal Reflux Disease (BY1023/DE-004)
- Enteral Nutrition as Stress Ulcer Prophylaxis in Critically Ill Patients.
- Comparison of 7-Day and 14-Day Bismuth Based Quadruple Therapy for Secondary Helicobacter Pylori Eradication
- Study Comparing 2 Different Formulations of Pantoprazole in Healthy Adults.
- Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis
- Comparison of the Classical Healing Concept With the Complete Remission Concept After Treatment With Pantoprazole in Adult Patients With Erosive GERD (Gastroesophageal Reflux Disease) (BY1023/M3-342)
- A Study of Rabeprazole and Pantoprazole on Stomach Acid and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease (GERD) and a History of Nighttime Heartburn
- A Comparative Study of Proton-pump Inhibitor Tests for Chinese Reflux Patients in Relation to the CYP2C19 Genotypes
- Famotidine Compared With Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Erosion
- Omeprazole and Pantoprazole Antiplatelet Effect of Clopidogrel Clinical Trials(OPEN)
- Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control
- Efficacy of Pantoprazole in Patients Older Than 12 Years With Reflux Associated Sleep Disorders (PULS)
- Comparison of the Nighttime Effects of Two Different Drugs on Subjects With GERD
- Bioequivalence Study of Pantoprazole Sodium 40 mg Delayed Release Tablets Fasting Study
- Evaluation of 24-Hour Intragastric pH Using Esomeprazole, Lansoprazole, and Pantoprazole in Hispanic Patients With GERD
- Study Evaluating the Efficacy and Safety of Pantoprazole in Infants With Symptomatic Gastroesophageal Reflux Disease (GERD)
- Pantoprazole on Insulin Secretion in Diabetes
- The Study of Eustachian Tube Dysfunction and Laryngopharyngeal Reflux
- Study to Investigate the Relative Bioavailability, Influence of Pantoprazole Coadministration and Food Effect of Different Oral Formulation of BI 113608
- Proton Pump Inhibitors in the Prevention of Iron Reaccumulation in Patient With Hereditary Hemochromatosis
- Symptom Evaluation After Cessation of a Proton Pump Inhibitor in Healthy Volunteers
- Pantoprazole and Docetaxel for Men With Metastatic Castration-Resistant Prostate Cancer
- Esophageal Metaplasia Using a Novel Antibody: Reversibility by Proton Pump Inhibitor
- Comparative Bioavailability Study of Two Test Products of Fixed Dose Combination Capsule of Acetylsalicylic Acid (ASA) and Pantoprazole (Each Capsule Contains ASA 100 mg and Pantoprazole 20 mg) Under Fed Conditions
- Comparison of a "Step-Up" Versus a "Step-Down" Treatment Strategy for Patients With New Onset Dyspepsia in General Practice (The DIAMOND-Study)
- Study of Intragastric pH Profile After 5 Days Pantoprazole 40 mg iv Followed by Oral Esomeprazole 40 mg po or Oral Pantoprazole 40 mg po
- Clinical Study, Multicenter, Randomized With 2 Arms of Pantoprazole + Domperidone and Pantoprazole Isolated at the Gastroesophageal Reflux Disease
- Influence of Pantoprazole to the Bioavailability of Myfortic® and CellCept®
- Effect of Pantoprazole on the Symptoms of Acid Reflux Disease in Adult Patients (BY1023/M3-341)
- Symptomatic Relief of Acute Dyspeptic Pain in Emergency Department With Pantoprazole
- Study of Pantoprazole for Sleepiness Associated With Acid Reflux and Sleep Apnea
- Study Evaluating Pantoprazole in Peptic Ulcer Hemorrhage
- Evaluation of Two Therapies for the Treatment of Osteoarticular Inflammation in Dyspeptic Patients
- Clinical Trial to Investigate the Effect of Proton Pump Inhibitor on the Pharmacokinetics and Pharmacodynamics of Metformin
- A Bioequivalence Study of SCH 530348 2.5 mg Tablets (P06558)
- Study Evaluating Pantoprazole in Neonates and Preterm Infants With GERD
- Bioequivalence Study of Pantoprazole Sodium 40 mg Delayed Release Tablets Fed Study
- Influence of Pantoprazole on Human Myocardial Contractility at Patients With Congestive Heart Failure
- Intravenous (IV) Pantoprazole for Gastroesophageal Reflux Disease (GERD) in Neonates and Infants
- Preventing Nephrotoxicity and Ototoxicity From Osteosarcoma Therapy
- Long-term Pantoprazole Trial in Patients With Symptoms of Chronic Acid Peptic Complaints (BY1023/VMG-708)
- Efficacy of Pantoprazole in Patients Older Than 18 Years Who Have Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/M3-339)
- Study Evaluating Pantoprazole in Adolescents With GERD
- Comparison of the Eradications Rates of Sequential Therapy Versus Concomitant Therapy
- Placebo-Controlled Crossover Study for the Investigation of the Effect of Pantoprazole on Cardiac Contractility
- On-Demand Use of Pantoprazole: Determinants for Chronic Use of Acid Suppressive Medication
- Bioequivalence Study of Pantoprazole 40 mg DR Tablets and Protonix 40 mg Tablets Under Fed Conditions
- Effect of Pantoprazole 40mg Daily vs Placebo on Power Spectral Analysis of the Sleep EEG of Patients With GERD.
- Comparative Bioavailability Study of Two Test Products of Fixed Dose Combination Capsule of ASA (Acetylsalicylic Acid) and Pantoprazole (Each Capsule Contains ASA 100 mg and Pantoprazole 20 mg) Under Fasting Conditions
- Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease
- Drug-drug Interaction Study in Healthy Male Volunteers Following the Administration of Pantoprazole and Rosuvastatin
- Study Evaluating Pantoprazole in Peptic Ulcer Hemorrhage
- Clopidogrel Proton-Pump Inhibitors Study
- Interaction Study of Clopidogrel 300/75 mg Given Alone or Concomitantly With Pantoprazole 80 mg in Healthy Subjects
- A Randomized, Open-Label, Comparative 3-Way Treatment Crossover Study of 24-Hour Intragastric pH Profile of Once Daily Oral Administration of Esomeprazole 40mg, Lansoprazole 30mg, and Pantoprazole 40mg at Steady State in NSAID-Using Patients
- Open Label Safety Study of Enteric-Coated Spheroid Suspension in Infants Aged Less Than 12 Months With Presumed Gastroesophageal Reflux Disease (GERD)
- Is Rebamipide Effective on the Healing of Iatrogenic Gastric Ulcer After Endoscopic Mucosal Resection?
- Comparison of Pantoprazole and Ranitidine in Dyspepsia
- Efficacy of Pantoprazole in Patients Older Than 12 Years Who Have Symptoms of Non-Erosive Reflux Disease (NERD) or Erosive Gastroesophageal Reflux Disease (eGERD)
- Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding
- Determination of the Minimal Clinically Important Difference After Treatment With Pantoprazole in Patients With Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/M3-340)
- A Prospective, Open Label Study Evaluating Two Management Strategies on Gastrointestinal Symptoms in Patients Newly on Treatment With Pradaxa for the Prevention of Stroke and Systemic Embolism With Non-valvular Atrial Fibrillation
- Structured Non-operative Treatment of Knee Osteoarthritis
- Efficacy/Safety Study as H. Pylori Eradication of Triple Therapy for 7 Days Treatment
- Indomethacin Prophylaxis for Heterotopic Ossification After Surgical Treatment of Elbow Trauma
- High Versus Standard Dose of Proton Pump Inhibitors (PPIs) in Peptic Ulcer Bleeding
- The Use of Oral Omeprazole and Intravenous Pantoprazole in Patients With Hypersecretion of Gastric Acid
- Incretin Effect and Use After Clinical Islet Transplantation
- Bioequivalence Study of Pantoprazole 40 mg DR Tablets and Protonix 40 mg Tablets