Nuplazid

Nuplazid treats hallucinations and delusions in patients with Parkinson’s disease. May cause swelling in the legs, ankles, and feet.

Nuplazid Overview

Reviewed: May 2, 2016
Updated: 

Nuplazid is a prescription medication used to treat hallucinations and delusions in patients with Parkinson’s disease. 

Nuplazid belongs to a group of drugs called atypical antipsychotics. These work to by altering the activity of certain natural substances in the brain.

This medication is available in tablet form and is typically taken once daily, with or without food. 

Common side effects of Nuplazid include swelling in ankles, legs, and feet, nausea, and confusion. 

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Nuplazid Cautionary Labels

precautionsprecautions

Uses of Nuplazid

Nuplazid is a prescription medication used to treat hallucinations and delusions associated with psychosis experienced by some people with Parkinson’s disease.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Nuplazid Drug Class

Nuplazid is part of the drug class:

Side Effects of Nuplazid

Serious side effects have been reported with Nuplazid. See "Drug Precautions" section.

Common side effects of Nuplazid include:

  • swelling in the ankles, legs, and feet
  • nausea
  • confusion
  • hallucinations
  • constipation
  • trouble walking

This is not a complete list of Nuplazid side effects. Ask your doctor or pharmacist for more information.

Tell your healthcare provider if you have any side effect that bothers you or does not go away. 

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Nuplazid Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • medications that block a protein in the body (CYP3A4) such as some macrolide antibiotics (clarithromycin, telithromycin), some HIV protease inhibitors (indinavir, nelfinavir, ritonavir, saquinavir), some HCV protease inhibitors (boceprevir, telaprevir), some azole antifungals (ketoconazole, itraconazole, posaconazole, voriconazole), delavirdine (Rescriptor), and nefazodone

  • medications that increase the activity of the enzyme CYP3A4 such as carbamazepine (Tegretol, Equetro, Carbatrol), phenobarbital, phenytoin (Dilantin), rifampin, and St John's wort

This is not a complete list of Nuplazid drug interactions. Ask your doctor or pharmacist for more information.

Nuplazid Precautions

Serious side effects have been reported with Nuplazid including:

  • Increased risk of death in elderly patients with dementia-related psychosis
    • Nuplazid is not approved for the treatment of patients with dementia-related psychosis unrelated to the hallucinations and delusions associated with Parkinson’s disease psychosis
  • QT Interval Prolongation. This is a condition when changes in the electrical activity of your heart occur, causing irregular heartbeats that can be life threatening. Talk to your healthcare provider about other medicines you are taking before you start taking Nuplazid. Tell your healthcare provider right away if you have any signs or symptoms of QT prolongation:
    • feeling faint
    • lightheadedness
    • dizziness
    • feeling like your heart is beating irregularly or quickly

Do not take Nuplazid if you are allergic to Nuplazid or to any of its ingredients.

Nuplazid Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Nuplazid, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Nuplazid, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Nuplazid or to any of its ingredients
  • have or have a history of any heart problems including any heart rhythm problems
  • have reduced kidney function. Nuplazid is not recommended if you have severe kidney problems
  • have reduced liver function. Nuplazid is not recommended if you have liver problems

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Nuplazid and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

There are no data on Nuplazid use in pregnant women. That said, the risk for major congenital malformations or miscarriage can not be assessed. In animal studies, no problems in regards to the baby's development were seen.
 

Nuplazid and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Nuplazid crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with the use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Nuplazid.

Nuplazid Usage

Take Nuplazid exactly as prescribed.

Nuplazid comes in tablet form and is taken by mouth, once a day, with or without food.

Nuplazid Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The recommended dose of Nuplazid for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis is two tablets (34 mg) once a day.

If you are taking certain medications, this dose may need to be reduced to one tablet (17 mg) once a day. Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Nuplazid Overdose

If you take too much Nuplazid, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Keep Nuplazid and all other medicines out of reach of children.
  • Store Nuplazid at room temperature 20°C to 25°C (68°F to 77°F)
     

Nuplazid FDA Warning

WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS

  • Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
  • Nuplazid is not approved for the treatment of patients with dementia-related psychosis unrelated to the hallucinations and delusions associated with Parkinson’s disease psychosis.