 is a prescription medication used to treat gastroesophageal reflux disease (GERD). It is also used to heal acid-related damage to the lining of the esophagus (erosive esophagitis), and to prevent ulcers caused by NSAIDs and H. Pylori bacteria. Nexium belongs to a group of drugs called proton pump inhibitors which work by decreasing the amount of acid produced in the stomach.This medication comes in capsule and powder form. It is usually taken once a day, at least one hour... "Pin It")
Nexium Overview
Nexium (generic: esomeprazole) is a prescription medication used to treat gastroesophageal reflux disease (GERD). It is also used to heal acid-related damage to the lining of the esophagus (erosive esophagitis), and to prevent ulcers caused by NSAIDs and H. Pylori bacteria. Nexium belongs to a group of drugs called proton pump inhibitors which work by decreasing the amount of acid produced in the stomach.
This medication comes in capsule and powder form. It is usually taken once a day, at least one hour before a meal.
Common side effects of Nexium include headache, diarrhea, and nausea.
Uses of Nexium
Nexium is a prescription medication used to treat the symptoms of gastroesophageal reflux disease (GERD). Nexium may also be prescribed to heal acid-related damage to the lining of the esophagus (erosive esophagitis), and to help continue this healing. Nexium is also used to prevent ulcers caused by NSAIDs and H. Pylori bacteria, and for Zollinger-Ellison syndrome.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Side Effects of Nexium
Nexium can cause serious side effects. See "Drug Precautions" section.
Nexium can cause serious allergic reactions. Tell your doctor if you get any of the following symptoms with Nexium.
- rash
- face swelling
- throat tightness
- difficulty breathing
Your doctor may stop Nexium if these symptoms happen.
Low magnesium levels in your body. This problem can be serious. Low magnesium can happen in some people who take a proton pump inhibitor medicine for at least 3 months. If low magnesium levels happen, it is usually after a year of treatment. You may or may not have symptoms of low magnesium.
Tell your doctor right away if you have any of these symptoms:
- seizures
- dizziness
- abnormal or fast heart beat
- jitteriness
- jerking movements or shaking (tremors)
- muscle weakness
- spasms of the hands and feet
- cramps or muscle aches
- spasm of the voice box
Your doctor may check the level of magnesium in your body before you start taking Nexium or during treatment if you will be taking Nexium for a long period of time.
The most common side effects with Nexium may include:
- Headache
- Diarrhea
- Nausea
- Gas
- Abdominal pain
- Constipation
- Dry mouth
- Drowsiness
People who are taking multiple daily doses of proton pump inhibitor medicines for a long period of time may have an increased risk of fractures of the hip, wrist or spine.
Using Nexium for a long period of time may increase the risk of inflammation to your stomach lining. You may or may not have symptoms. Tell your doctor if you have stomach pain, nausea, vomiting, or weight loss.
Tell your doctor about any side effects that bother you or that do not go away. These are not all the possible side effects with Nexium. Talk with your doctor or pharmacist if you have any questions about side effects.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Nexium Interactions
Tell your doctor about all of the medicines you take including prescription and non-prescription drugs, vitamins and herbal supplements. Nexium may affect how other medicines work, and other medicines may affect how Nexium works. Especially tell your doctor if you take:
- warfarin (Coumadin, Jantoven)
- ketoconazole (Nizoral)
- voriconazole (Vfend)
- atazanavir (Reyataz)
- nelfinavir (Viracept)
- saquinavir (Fortovase)
- products that contain iron
- digoxin (Lanoxin, Lanoxicaps)
- St.John’s Wort (Hypericum perforatum)
- Rifampin (Rimactane, Rifater, Rifamate)
- cilostazol (Pletal)
- diazepam (Valium)
- tacrolimus (Prograf)
- Erlotinib (Tarceva)
- Methotrexate
- clopidogrel (Plavix)
This is not a complete list of Nexium drug interactions. Ask your doctor or pharmacist for more information.
Nexium Precautions
Nexium may help your acid-related symptoms, but you could still have serious stomach problems. Talk to your doctor.
Nexium can cause serious side-effects including:
- Diarrhea. Nexium may increase your risk of getting severe diarrhea. This diarrhea may be caused by an infection (Clostridium difficile) in your intestines. Call your doctor right away if you have watery stool, stomach pain, and fever that does not go away.
- Bone fractures. People who take multiple daily doses of Proton Pump Inhibitor medicines for a long period of time (a year or longer) may have an increased risk of fractures of the hip, wrist, or spine. You should take Nexium exactly as prescribed, at the lowest dose possible for your treatment and for the shortest time needed. Talk to your doctor about your risk of bone fracture if you take Nexium.
Do not take Nexium if you:
- are allergic to any of the ingredients in Nexium.
- are allergic to any other Proton Pump Inhibitor (PPI) medicine.
Nexium Food Interactions
Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Nexium there are no specific foods that you must exclude from your diet when receiving Nexium.
Inform MD
Tell your doctor about all your medical conditions, including if you:
- have been told that you have low magnesium levels in your blood
- have liver problems
- are pregnant, think you may be pregnant, or are planning to become pregnant.
- are breastfeeding or planning to breastfeed. Talk with your doctor about the best way to feed your baby if you take Nexium.
Tell your doctor about all of the medicines you take including prescription and non-prescription drugs, vitamins and herbal supplements.
Nexium and Pregnancy
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if Nexium will harm your unborn baby.
Nexium and Lactation
Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if Nexium is excreted in human breast milk or if it will harm your nursing baby.
Nexium Usage
- Take Nexium exactly as prescribed by your doctor.
- Do not change your dose or stop Nexium without talking to your doctor.
- Take Nexium at least 1 hour before a meal.
- Swallow Nexium capsules whole. Never chew or crush Nexium.
- If you have difficulty swallowing Nexium capsules, you may open the capsule and empty the contents into a tablespoon of applesauce. Be sure to swallow the applesauce right away. Do not store it for later use.
- If you forget to take a dose of Nexium, take it as soon as you remember. If it is almost time for your next dose, do not take the missed dose. Take the next dose on time. Do not take a double dose to make up for a missed dose.
- If you take too much Nexium, tell your doctor right away.
Take Nexium for Delayed-Release Oral Suspension as follows:
- Nexium for Delayed-Release Oral Suspension comes in foil packets containing 2.5 mg, 5 mg, 10 mg, 20 mg, or 40 mg strengths.
- You should use an oral syringe to measure the amount of water needed to mix your dose. Ask your pharmacist for an oral syringe.
- If your prescribed dose is 2.5 mg or 5 mg, add 5 mL of water to a container, then add the contents of a foil packet containing the dose prescribed by your doctor.
- If your prescribed dose is 10 mg, 20 mg, or 40 mg, add 15 mL of water to a container, then add the contents of a foil packet containing the dose prescribed by your doctor.
- If you or your child are instructed to use more than one foil packet for the prescribed dose, follow the mixing instructions provided by your pharmacist or doctor.
- Stir.
- Leave 2 to 3 minutes to thicken.
- Stir and take dose within 30 minutes. If not used within 30 minutes, throw away this dose and mix a new dose.
- If any medicine remains after drinking, add more water, stir, and take dose right away.
- For young children, you can give the dose with an oral syringe. Rinse the oral syringe with water after each use.
Nexium Delayed-Release Capsules and Nexium for Delayed-Release Oral Suspension may be given through a nasogastric tube (NG tube) or gastric tube, as prescribed by your doctor. Follow the instructions below:
Nexium Delayed-Release Capsules:
- Open the capsule and empty the granules into a 60 mL catheter tipped syringe. Mix with 50 mL of water. Use only a catheter tipped syringe to give Nexium through a NG tube.
- Replace the plunger and shake the syringe well for 15 seconds. Hold the syringe with the tip up and check for granules in the tip.
- Give the medicine right away.
- Do not give the granules if they have dissolved or have broken into pieces.
- Attach the syringe to the NG tube. Give the medicine in the syringe through the NG tube into the stomach.
- After giving the granules, flush the NG tube with more water.
Nexium for Delayed-Release Oral Suspension:
- Nexium for Delayed-Release Oral Suspension comes in foil packets containing 2.5 mg, 5 mg, 10 mg, 20 mg, or 40 mg strengths.
- Use only a catheter tipped syringe to give Nexium through a NG tube or gastric tube
- If your prescribed dose is 2.5 mg or 5 mg, add 5 mL of water to a catheter tipped syringe, then add the contents of a foil packet containing the dose prescribed by your doctor.
- If your prescribed dose is 10 mg, 20 mg, or 40 mg, add 15 mL of water to a catheter tipped syringe, then add the contents of a foil packet containing the dose prescribed by your doctor.
- Shake the syringe right away and then leave it for 2 to 3 minutes to thicken.
- Shake the syringe and give the medicine through the NG or gastric tube (French size 6 or larger) into the stomach within 30 minutes.
- Refill the syringe with the same amount of water (either 5 mL or 15 mL of water depending on your dose).
- Shake the syringe and flush any remaining medicine from the NG tube or gastric tube into the stomach.
Nexium Overdose
If you take too much Nexium, call your local Poison Control Center or seek emergency medical attention right away.
Forms of Nexium
NEXIUM Delayed-Release Capsules, 20 mg and 40 mg
NEXIUM For Delayed-Release Oral Suspension
- 2.5 mg packets
- 5 mg packets
- 10 mg packets
- 20 mg packets
- 40 mg packets
Active ingredient: esomeprazole magnesium trihydrate
Inactive ingredients in Nexium Delayed-Release Capsules (including the capsule shells): glyceryl monostearate 40-55, hydroxypropyl cellulose, hypromellose, magnesium stearate, methacrylic acid copolymer type C, polysorbate 80, sugar spheres, talc, triethyl citrate, gelatin, FD&C Blue #1, FD&C Red #40, D&C Red #28, titanium dioxide, shellac, ethyl alcohol, isopropyl alcohol, n-butyl alcohol, propylene glycol, sodium hydroxide, polyvinyl pyrrolidone, and D&C Yellow #10.
Inactive granules in Nexium Delayed-Release Oral Suspension: dextrose, xanthan gum, crospovidone, citric acid, iron oxide, and hydroxypropyl cellulose.
Other Requirements
Store Nexium at room temperature between 68°F to 77°F (20°C to 25°C).
Keep the container of Nexium closed tightly.
Keep Nexium and all medicines out of the reach of children.
Medicines are sometimes prescribed for purposes other than those listed in the Patient Information leaflet. Do not use Nexium for a condition for which it was not prescribed. Do not give Nexium to other people, even if they have the same symptoms you have. It may harm them.
