Nexavar (generic: sorafenib) is a prescription medication used to treat adults with certain types of liver and kidney cancers. Nexavar belongs to a group of drugs called kinase inhibitors, which by blocking proteins called kinases which are needed for cell growth.
This medication comes in tablet form and is taken twice a day, without food.
Common side effects of Nexavar include rash or itching of the skin, hair thinning, diarrhea, and weight loss.
Nexavar is a prescription medication used to treat adults with hepatocellular carcinoma (HCC, type of liver cancer) that can not be treated with surgery. It is also used to treat renal cell carcinoma (RCC, type of kidney cancer).
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Nexavar may cause serious side effects, including:
- decreased blood flow to the heart and heart attack. Get emergency help right away and call your doctor if you get symptoms such as chest pain, shortness of breath, feel lightheaded or faint, nausea, vomiting, sweating a lot.
- bleeding problems. Nexavar may increase your chance of bleeding. Tell your doctor if you have any bleeding while taking Nexavar.
- high blood pressure. Your blood pressure should be checked every week during the first 6 weeks of starting Nexavar. Your blood pressure should be checked regularly and any high blood pressure should be treated while you are receiving Nexavar.
- a skin problem called hand-foot skin reaction. This causes redness, pain, swelling, or blisters on the palms of your hands or soles of your feet. If you get this side effect, your doctor may change your dose or stop treatment for some time.
- perforation of the bowel. Tell your doctor right away if you get high fever, nausea, vomiting, severe abdominal pain.
- possible wound healing problems. If you need to have a surgical or dental procedure, tell your doctor that you are taking Nexavar. Nexavar may need to be stopped until your wound heals after some types of surgery.
- birth defects or death of an unborn baby.
Other side effects with Nexavar may include:
- rash, redness, itching or peeling of your skin
- hair thinning or patchy hair loss
- diarrhea (frequent or loose bowel movements)
- nausea or vomiting
- mouth sores
- loss of appetite
- numbness, tingling or pain in your hands and feet
- abdominal pain
- weight loss
Tell your doctor if you have any side effects that bother you or that do not go away. These are not all the side effects with Nexavar. Ask your doctor or pharmacist for more information.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Nexavar and certain other medicines can interact with each other and cause serious side effects. Especially tell your doctor if you are taking the following medicines:
Do not take Nexavar if you:
Grapefruit and grapefruit juice may interact with Nexavar and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
Tell your doctor about all of your health conditions, including if you:
- have any allergies
- have heart problems (including a problem called "congenital long QT syndrome",
- have chest pain
- have bleeding problems
- have high blood pressure
- have kidney problems in addition to kidney cancer
- have liver problems in addition to liver cancer
- are pregnant or planning to become pregnant.
- are breastfeeding or planning to breastfeed. It is not known if Nexavar passes into your breast milk. You and your doctor should decide if you will take Nexavar or breast-feed. You should not do both.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Nexavar and certain other medicines can interact with each other and cause serious side effects. Especially, tell your doctor if you take warfarin (Coumadin).
Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine. Do not take other medicines with Nexavar until you have talked with your doctor.
Tell your doctor if you are pregnant or plan to become pregnant. Nexavar may harm your unborn baby.
Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if Nexavar passes into your breast milk. You and your doctor should decide if you will take Nexavar or breastfeed. You should not do both.
- Take Nexavar exactly as prescribed by your doctor.
- The usual dose of Nexavar is 2 tablets taken two times a day (for a total of 4 tablets each day). Your doctor may change your dose during treatment or stop treatment for some time if you have side effects.
- Swallow Nexavar tablets whole with water.
- Take Nexavar without food (at least 1 hour before or 2 hours after a meal).
- If you miss a dose of Nexavar, skip the missed dose, and take your next dose at your regular time. Do not double your dose of Nexavar. Call your doctor right away if you take too much Nexavar.
Take Nexavar exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you. The usual dose of Nexavar is 2 tablets taken two times a day (for a total of 4 tablets each day). Your doctor may change your dose during treatment or stop treatment for some time if you have side effects.
If you take too much Nexavar call your local Poison Control Center or seek emergency medical attention right away.
Nexavar is available in 200 mg tablets.
Active Ingredient: sorafenib tosylate
Inactive Ingredients: croscarmellose sodium, microcrystalline cellulose, hypromellose, sodium lauryl sulphate, magnesium stearate, polyethylene glycol, titanium dioxide and ferric oxide red.
Store Nexavar tablets at room temperature between 59° to 86° F (15° to 30° C), in a dry place.
Keep Nexavar and all medicines out of the reach of children.