High-Cholesterol Diet? Forget It

High-fat diet causes memory impairment in rats, similar to Alzheimer’s pathology

/ Author:  / Reviewed by: Joseph V. Madia, MD

(RxWiki News) A chronic high-fat cholesterol diet produced pathologies similar to Alzheimer's disease in rats.

The findings arrive from the Laboratory of Psychiatry and Experimental Alzheimers Research at the Medical University Innsbruck in Austria and have been published in Molecular Cellular Neuroscience.

Dysregulation of amyloid-precursor protein expression and beta-amyloid clearance is thought to be one possible cause of Alzheimer’s, though scientists have not settled on a definitive causal explanation. It’s been suggested that the disease begins 20 – 30 years before symptoms first appear. High cholesterol levels are linked to the disease’s pathology.

The aim of the study was to study the effects of hypercholesterolemia in adult rats. Results showed that chronic hypercholesterolemia caused memory impairment in the rats along with a series of other symptoms that indicate an Alzheimer’s disease-like pathology.

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Review Date: 
November 25, 2010
Last Updated:
November 29, 2010