Neurontin

Neurontin treats certain types of seizures and helps with nerve pain. Can cause dizziness and drowsiness. Do not drive a car or operate heavy machinery until you know how it affects you.

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Pharmacist Jobby John, PharmD overviews the uses and common side effects of Neurontin
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Pharmacist Jobby John, PharmD overviews the uses and common side effects of Neurontin
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Neurontin Overview

Updated: 

Neurontin is a prescription medication used to treat adults with nerve pain caused by shingles. Shingles is a painful rash that is caused by the varicella-zoster virus, the virus that also causes chickenpox. Neurontin is also used in combination with other medications to treat partial seizures. Neurontin belongs to a group of drugs called anticonvulsants, which help treat seizures by decreasing abnormal excitement in the brain. It also works by altering the way the body senses pain.

This medication comes in tablet, capsule, and oral (by mouth) solution forms and is taken up to 3 times a day, with or without food. The capsules are taken with a full glass of water.

Common side effects of Neurontin include lack of coordination, dizziness, and drowsiness. Do not drive a car or operate heavy machinery until you know how this medication affects you.

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  • Bipolar Disorder
  • Epilepsies, Partial
  • Epilepsy
  • Pain
  • Phobic Disorders

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Neurontin Cautionary Labels

precautionsprecautionsprecautionsprecautionsprecautionsprecautionsprecautionsprecautions

Uses of Neurontin

Neurontin is a prescription medicine used to treat:

  • Pain from damaged nerves (postherpetic pain) that follows healing of shingles (a painful rash that comes after a herpes zoster infection) in adults.
  • Partial seizures when taken together with other medicines in adults and children 3 years of age and older.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Neurontin Drug Class

Neurontin is part of the drug class:

Side Effects of Neurontin

Serious side effects have been reported with Neurontin. See “Drug Precautions” section.

The most common side effects of Neurontin include:

  • dizziness
  • lack of coordination
  • viral infection
  • feeling drowsy
  • feeling tired
  • fever
  • jerky movements
  • difficulty with speaking
  • temporary loss of memory 
    (amnesia)
  • tremor
  • difficulty with coordination
  • double vision
  • unusual eye movement

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Neurontin. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Neurontin Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • hydrocodone (found in medications such as Vicodin, Norco, and Lorcet)
  • morphine (found in medications such as Kadian, MS Contin, and RMS Suppository)
  • Maalox

This is not a complete list of Neurontin drug interactions. Ask your doctor or pharmacist for more information.

Neurontin Precautions

Do not stop taking Neurontin without first talking to your healthcare provider. Stopping Neurontin suddenly can cause serious problems.

Neurontin can cause serious side effects including:

1.  Like other antiepileptic drugs, Neurontin may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.

Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

  • thoughts about suicide or dying
  • attempts to commit suicide
  • new or worse depression
  • new or worse anxiety
  • feeling agitated or restless
  • panic attacks
  • trouble sleeping (insomnia)
  • new or worse irritability
  • acting aggressive, being angry, or violent
  • acting on dangerous impulses
  • an extreme increase in activity and talking (mania)
  • other unusual changes in behavior or mood

How you can watch for early symptoms of suicidal thoughts and actions:

  • Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings.
  • Keep all follow-up visits with your healthcare provider as scheduled.

Call your healthcare provider between visits as needed, especially if you are worried about symptoms.

Do not stop taking Neurontin without first talking to a healthcare provider.

  • Stopping Neurontin suddenly can cause serious problems. Stopping a seizure medicine suddenly in a patient who has epilepsy can cause seizures that will not stop (status epilepticus).

Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes.

2.  Changes in behavior and thinking - Using Neurontin in children 3 to 12 years of age can cause emotional changes, aggressive behavior, problems with concentration, restlessness, changes in school performance, and hyperactivity.
 
3.  Neurontin may cause a serious or life-threatening allergic reaction that may affect your skin or other parts of your body such as your liver or blood cells. You may or may not have a rash when you get this type of reaction. It may cause you to be hospitalized or to stop Neurontin. Call a healthcare provider right away if you have any of the following symptoms:
  • skin rash
  • hives
  • fever
  • swollen glands that do not go away
  • swelling of your lip and tongue
  • yellowing of your skin or of the whites of the eyes
  • unusual bruising or bleeding
  • severe fatigue or weakness
  • unexpected muscle pain
  • frequent infections

These symptoms may be the first signs of a serious reaction. A healthcare provider should examine you to decide if you should continue taking Neurontin.

Do not take Neurontin if you are allergic toNeurontin or any of its ingredients. 

Do not drink alcohol or take other medicines that make you sleepy or dizzy while taking Neurontin without first talking with your healthcare provider. Taking Neurontin with alcohol or drugs that cause sleepiness or dizziness may make your sleepiness or dizziness worse.

Do not drive, operate heavy machinery, or do other dangerous activities until you know how Neurontin affects you. Neurontin can slow your thinking and motor skills.

Neurontin Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Neurontin there are no specific foods that you must exclude from your diet when receiving Neurontin.

Inform MD

Before taking Neurontin, tell your healthcare provider if you:

  • have or have had kidney problems or are on hemodialysis
  • have or have had depression, mood problems, or suicidal thoughts or behavior
  • are pregnant or plan to become pregnant. 
  • are breastfeeding or plan to breastfeed. 

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Taking Neurontin with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider.

Know the medicines you take. Keep a list of them and show it to your healthcare provider and pharmacist when you get a new medicine.

Neurontin and Pregnancy

Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if Neurontin can harm your unborn baby. Tell your healthcare provider right away if you become pregnant while taking Neurontin. You and your healthcare provider will decide if you should take Neurontin while you are pregnant.

  • If you become pregnant while taking Neurontin, talk to your healthcare provider about registering with the North American Antiepileptic Drug (NAAED) Pregnancy Registry. The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy. You can enroll in this registry by calling 1-888-233-2334.

Neurontin and Lactation

Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Neurontin can pass into breast milk. You and your healthcare provider should decide how you will feed your baby while you take Neurontin.

Neurontin Usage

  • Take Neurontin exactly as prescribed. Your healthcare provider will tell you how much Neurontin to take.
    • Do not change your dose of Neurontin without talking to your healthcare provider. If you break a tablet in half, the unused half of the tablet should be taken at your next scheduled dose. Half tablets not used within several days of breaking should be thrown away. If taking capsules, always swallow them whole with plenty of water.
  • Neurontin can be taken with or without food. If you take an antacid containing aluminum and magnesium, such as Maalox, Mylanta, Gelusil, Gaviscon, or Di-Gel, you should wait at least 2 hours before taking your next dose of Neurontin.
  • If you take too much Neurontin, call your healthcare provider or your local Poison Control Center right away.
  • Do not drink alcohol or take other medicines that make you sleepy or dizzy while taking Neurontin without first talking with your healthcare provider. Taking Neurontin with alcohol or drugs that cause sleepiness or dizziness may make your sleepiness or dizziness worse.
  • Do not drive, operate heavy machinery, or do other dangerous activities until you know how Neurontin affects you. Neurontin can slow your thinking and motor skills.

Neurontin Dosage

Postherpetic Neuralgia:

In adults with postherpetic neuralgia, Neurontin therapy may be started as a single 300-mg dose on Day 1, 600 mg/day on Day 2 (divided twice daily), and 900 mg/day on Day 3 (divided three times daily). The dose can be increased as needed for pain relief to a daily dose of 1800 mg (divided three times daily). Additional benefit of using doses greater than 1800 mg/day was not shown.

Epilepsy:

Neurontin is recommended for as add-on therapy in patients 3 years of age and older. Effectiveness in children below the age of 3 years has not been established.

Patients >12 years of age:

The effective dose of Neurontin is 900 to 1800 mg/day and given in divided doses (three times a day). The starting dose is 300 mg three times a day. If necessary, the dose may be increased to three times a day up to 1800 mg/day. The maximum time between doses in the three times daily schedule should not exceed 12 hours.

Pediatric Patients Age 3–12 years:

The starting dose should range from 10–15 mg/kg/day in 3 divided doses, and the dose can be increased gradually over approximately 3 days.

  • The effective dose of Neurontin in patients 5 years of age and older is 25–35 mg/kg/day and given in divided doses (three times a day).
  • The effective dose in pediatric patients ages 3 and 4 years is 40 mg/kg/day and given in divided doses (three times a day).

The maximum time interval between doses should not exceed 12 hours.

Kidney Dysfunction:

Dosing is also based on the functional status of your kidneys.

Stopping Neurontin:

If Neurontin is stopped and/or a different anticonvulsant medication is added to the therapy, this should be done gradually over a minimum of 1 week.

Neurontin Overdose

If you take too much Neurontin, call your healthcare provider or your local Poison Control Center right away.

Other Requirements

  • Store Neurontin capsules between 59°F to 86°F (15°C to 30°C).
  • Store Neurontin tablets between 59°F to 86°F (15°C to 30°C).
  • Store Neurontin oral solution in the refrigerator between 36°F to 46°F (2°C to 8°C).

Keep Neurontin and all medicines out of the reach of children.