Neumega prevents low platelet levels in the blood after chemotherapy. It may take 10 to 21 days for your platelet numbers to increase and the time it will take will vary by patient.

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Pharmacist Amanda McCoy, Pharm.D. overviews usage and side effects of Neumega.
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Neumega Overview


Neumega is a prescription medication used to prevent low platelet levels in the blood after certain types of chemotherapy. Neumega belongs to a group of drugs called thrombopoietic growth factors, which help the body make more platelets.

This medication comes in an injectable form and is given just under the skin once daily.

Common side effects include slight water weight gain, shortness of breath, and low red blood cell count (anemia).

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Neumega Cautionary Labels


Uses of Neumega

Neumega is a prescription medication for people who have received certain types of chemotherapy and is used to stimulate the bone marrow to produce platelets to prevent the number of platelets circulating in the blood from dropping dangerously low. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.



Neumega Drug Class

Neumega is part of the drug class:

Side Effects of Neumega

The most common, but less serious side effects, are:

  • Slight water weight gain
  • Some swelling in the arms and/or legs
  • Shortness of breath when walking or moving around
  • Anemia (low red blood cell count)

These side effects may be caused by water retention. For most people, the water weight gain will go away a few days after the last injection of Neumega. Make sure you have read and understand the section called “Drug Precautions”, because many of these side effects could develop into a more serious condition.

Other side effects that you should tell your doctor about are:

  • Blurred vision, headaches, or redness of the eyes
  • Any swelling or bruising that doesn't go away in the location where you have injected Neumega 

This is not a complete list of Neumega side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

If you have any other problems, whether or not you think they are related to Neumega, you should call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.


Neumega Interactions

No Neumega drug interactions have been identified, however, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.


Neumega Precautions

Neumega may have side effects; some of these side effects may be serious. The most serious possible side effects of treatment with Neumega include:

  • Allergic Reactions. Neumega can cause serious allergic reactions in some patients. Signs that you are having a serious allergic reaction include: swelling of your face, tongue or throat; difficulty breathing, swallowing or talking; shortness of breath; wheezing; chest pain; a tightness in your throat; feeling lightheaded; loss of consciousness; confusion; drowsiness; rash; itching; hives; flushing and/or fever. You or your caregiver should call your doctor immediately if you develop any of these signs or symptoms.
  • Heart Problems. Neumega can cause heart problems in some patients. If you feel like your heart is pounding, beating fast or skipping a beat, or you have chest pains or are short of breath, you should call your doctor immediately. If you have ever had heart problems, you should tell your doctor before you start treatment with Neumega.

If you are taking a water pill (diuretic), you should tell your doctor, because the diuretic can cause your body to lose potassium. This is very important, because Neumega can cause heart problems and these heart problems could be more serious when the potassium in your blood is too low. Your doctor will be checking your blood for the amount of potassium in it. If your potassium level is low, your doctor may prescribe a potassium replacement medication to correct it.

  • Water Weight Gain. Neumega may cause you to retain water and gain weight from the extra fluid in your body. For some patients, water weight gain may cause serious problems that require medicine or hospitalization. A small amount of water weight gain will usually go away within several days after you stop taking Neumega. But, if you have a rapid weight gain over a few days, swelling of the legs and feet, dizziness, shortness of breath or chest pain, it could mean that you have a serious condition with fluid around the lungs and heart. If you have ever had heart failure or are taking medicine that may cause you to retain water, you should tell your doctor before you start treatment with Neumega.
  • Eye Problem. Neumega can cause or worsen an eye problem called papilledema. Papilledema is swelling of the optic (eye) nerve. Papilledema can cause changes in your eyesight from blurred vision to blindness.
  • Children Receiving Neumega . Because Neumega is approved only for use in adults, you should talk to your child's doctor about the reasons why Neumega has been prescribed for your child. You should talk to your child's doctor about the risks and side effects of using this medication in children. One of the side effects seen in children taking Neumega is a serious eye condition called papilledema which is a form of swelling of the nerve that enters the back of the eye. Many children may not show any signs of papilledema. If your child complains that they have a headache or are having difficulty seeing, call your child's doctor right away. Other side effects that have been seen in children are fast heartbeat, redness of the eye, changes to the heart, and changes to bones that can be seen on x-ray.

Stop taking Neumega and call your doctor or healthcare provider immediately if you develop any of these symptoms:

  • Shortness of breath or trouble breathing
  • Chest pains
  • Swelling in your face, hands, or feet
  • Rapid weight gain over a few days
  • You feel like your heart is pounding or beating out of your chest or skipping a beat, also referred to as palpitations
  • Changes in your eyesight including blurred vision and blindness

Do not take Neumega if you have ever had or think you have had an allergic reaction to Neumega. Talk to your doctor if you have any questions about this information.

Neumega Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Neumega, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before you start taking Neumega, you should tell your doctor the names of all of the medications you are taking including prescription and non-prescription drugs, vitamins, and nutritional supplements. If you have any of the following conditions or medical problems, tell your doctor or healthcare provider:

  • You are pregnant or planning to become pregnant
  • Breastfeeding
  • You have heart problems
  • You have kidney disease
  • You have eye problems

Neumega and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category C. There are no well-controlled studies that have been done in pregnant women. Neumega should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

Neumega and Lactation

Tell your doctor if you are breastfeeding. It is not known if Neumega is excreted in human breast milk or if it will harm your nursing baby. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Neumega.

Neumega Usage

To see if Neumega is working, your doctor will ask you to have blood tests done to measure the number of platelets in your body. After starting Neumega, it may take 10 to 21 days for your platelet numbers to increase. The amount of time it takes to increase the number of platelets varies from patient to patient. Neumega may not work for everyone and you may still need platelet transfusions or have bleeding even if you take Neumega as directed by your doctor. You should always follow your doctor's instructions.

If your doctor has recommended that you receive Neumega at home, then you and/or your caregiver should be instructed on how to prepare Neumega , how much Neumega to use, how to inject it, how often it should be injected, and how to dispose of the unused portions of each bottle. Do not inject Neumega until you are comfortable with the steps to prepare and inject Neumega at home.

You should always change the site of your injections each day to avoid soreness at any one site. Your injections should be given about the same time each day. If you miss an injection on one day, you should not try to add it on the next day. Tell your doctor that you missed a dose and continue as usual with your next scheduled dose. 

Neumega Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • how you respond to this medication
  • your weight
  • your renal function

The recommended dose of Neumega to stimulate the bone marrow, in patients without severe renal impairment, is 50 mcg/kg once daily.

Neumega Overdose

If you take too much Neumega, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If Neumega is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

It is important that you do not take any more or less of the amount of Neumega that your doctor prescribed. Too much Neumega might put you at risk for irregular heartbeats and water retention (including fluid around the heart and lungs).


Other Requirements

The kit containing the bottle of powdered Neumega and the pre-filled syringe should be kept in a refrigerator. Do not freeze. 

The Neumega powder must be protected from light.

Every time you give yourself a dose of Neumega, you must use a new bottle of Neumega powder and a new pre-filled syringe of Sterile Water for Injection, USP. There is an expiration date printed on the bottle of the Neumega powder and on the pre-filled syringe. Do not use the Neumega or the pre-filled syringe if it is past the expiration date (month and year).

After you mix the Neumega with the Sterile Water for Injection, USP, you must use it as soon as possible. Do not let more than three (3) hours go by between the time you mix the Neumega and the water, and the time that you use it. The Neumega and Sterile Water for Injection, USP mixture can be stored in the Neumega bottle for up to three (3) hours either at room temperature or in the refrigerator. Remember to keep the bottle out of the light. Do not store the Neumega and Sterile Water for Injection, USP mixture in a syringe.

After you give yourself an injection of Neumega, discard the Neumega bottle and syringe with the needle attached into the “Sharps Container”.

Do not dispose of the Sharps Containers in household trash. Do not recycle.

Neumega FDA Warning

Allergic Reactions Including Anaphylaxis

Neumega has caused allergic or hypersensitivity reactions, including anaphylaxis. Administration of Neumega should be permanently discontinued in any patient who develops an allergic or hypersensitivity reaction.