Movantik

Movantik treats constipation caused by certain pain medications. Grapefruit and grapefruit juice may interact with Movantik. Discuss the use of grapefruit products with your doctor.

Movantik Overview

Reviewed: September 16, 2014
Updated: 

Movantik is a prescription medication used to treat opioid-induced constipation in adults with chronic non-cancer pain. Movantik belongs to a group of drugs called mu-receptor opioid antagonists. These work by blocking the effects of opioid pain medications on the gastrointestinal tract.

This medication comes in oral tablet form and is taken once daily on an empty stomach. Movantik should be taken at least 1 hour before the first meal of the day or 2 hours after the meal.

Do not chew, divide, or break Movantik tablets. Swallow the tablets whole.

Common side effects of Movantik include abdominal pain, diarrhea, nausea, flatulence, vomiting, and headache.

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Movantik Cautionary Labels

precautionsprecautionsprecautions

Uses of Movantik

Movantik is a prescription medication used to treat opioid-induced constipation in adults with chronic non-cancer pain.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Movantik Drug Class

Movantik is part of the drug class:

Side Effects of Movantik

Serious side effects have been reported with Movantik. See the “Movantik Precautions” section.

Common side effects of Movantik include the following:

  • abdominal pain
  • diarrhea
  • nausea
  • flatulence
  • vomiting
  • headache

This is not a complete list of Movantik side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Movantik Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • Ketoconazole (Nizoral)
  • Itraconazole (Sporanox)
  • Clarithromycin (Biaxin)
  • Diltiazem (Cardizem, Dilacor, Taztia XT, Tiazac and other)
  • Erythromycin (E-mycin, Ery-Sol, Ery-Tab, Erythrocin, in Pediazole)
  • Verapamil (Calan, COvera, Isoptin, Tarka, Verelan)
  • Quinidine (Cardioquin, Duraquin, Quinact)
  • Cimetidine (Tagamet)
  • Rifampin (Rifadin)
  • Carbamazepine (Carbatrol, Epitol, Tegretol)
  • St. John’s Wort
  • Other opioid antagonists such as alvimopan (Entereg) and methylnaltrexone (Relistor)

This is not a complete list of Movantik drug interactions. Ask your doctor or pharmacist for more information.

Movantik Precautions

Serious side effects have been reported with Movantik including the following:

  • Gastrointestinal perforation. Tell your healthcare provider right away if you have some or all of the following symptoms of gastrointestinal perforation, including severe, persistent, or worsening abdominal pain.
  • Opioid withdrawal. Tell your healthcare provider right away if you have some or all of the following symptoms of opioid withdrawal, including
    • Excessive sweating
    • Chills
    • Diarrhea
    • Abdominal pain
    • Anxiety
    • Irritability
    • Yawning

Do not take Movantik if you:

  • are allergic to Movantik or to any of its ingredients
  • have a known or suspected gastrointestinal obstruction
  • are taking other medications that are strong inhibitors of certain liver enzymes

Movantik Food Interactions

Grapefruit and grapefruit juice may interact with Movantik and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Inform MD

Before taking Movantik, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Movantik or to any of its ingredients
  • have or have had stomach or bowel problems, including ulcers, Crohn’s disease, diverticulitis, and cancer of the stomach or bowel
  • have liver problems
  • have kidney problems
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Movantik and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Movantik falls into category C. There are no well-controlled studies that have been done in pregnant women. Movantik may induce opioid withdrawal in fetuses. Movantik should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

Movantik and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Movantik crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Movantik.

Movantik Usage

Take Movantik exactly as prescribed.

This medication comes in oral tablet form and is taken once daily on an empty stomach. Do not chew, divide, or break Movantik tablets. Swallow the tablets whole.

Movantik should be taken at least 1 hour before the first meal of the day or 2 hours after the meal.

You should stop taking other laxatives before beginning Movantik.

Tell your doctor if you stop taking your opioid medication. You may also need to stop Movantik.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Movantik at the same time.

Movantik Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medications you are taking
  • how you respond to this medication

The recommended dose of Movantik for the treatment of opioid-induced constipation is 25 mg once daily. The dose may be reduced to 12.5 mg daily if the higher dose is not tolerated.

Movantik Overdose

If you take too much Movantik, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If Movantik is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

Store Movantik at room temperature.

Keep this and all medicines out of the reach of children.