MIlrinone treats severe heart failure. Is mixed with dextrose, a type of sugar, before it is given. If you have high blood sugar (diabetes) or have low blood sugar, tell your doctor.
Milrinone is a prescription medication used for short-term treatment of acute decompensated heart failure (a specific type of heart problem). Milrinone belongs to a group of drugs called inotropes, which work by helping the heart pump more blood through the body.
This medication comes in an injectable form to be given directly into the vein (IV) by a healthcare professional. It is usually given continuously (24 hours per day) in the vein (IV).
Common side effects of milrinone include abnormal heart rhythm, and headache. Milrinone can also cause changes in blood pressure, which can cause dizziness or fainting. Do not drive or operate heavy machinery until you know how milrinone affects you. Get out of bed slowly to avoid dizziness or fainting.
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Uses of Milrinone
Milrinone is a prescription medication used for short-term treatment of acute decompensated heart failure (a specific type of heart problem).
Milrinone Brand Names
Milrinone may be found in some form under the following brand names:
Milrinone Drug Class
Milrinone is part of the drug class:
Side Effects of Milrinone
Serious side effects have been reported with milrinone. See the “Drug Precautions” section.
- abnormal heart rhythm
- abnormal heart beats or extra heart beats
- increased heart rate
- dizziness or fainting
- abnormal liver function test results (measured in the blood)
- blood sugar problems in diabetic patients
This is not a complete list of milrinone side effects. Ask your doctor or pharmacist for more information.
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
- diuretic medications used to reduce swelling and extra water such as furosemide (Lasix), torsemide (Demadex), bumetanide (Bumex), or metolazone (Zaroxolyn)
This is not a complete list of milrinone drug interactions. Ask your doctor or pharmacist for more information.
Serious side effects have been reported with milrinone including the following:
- hypersensitivity (severe allergic reaction). Tell your healthcare provider about any signs or symptoms of hypersensitivity, which include the following:
- chest pain
- swelling of the face, eyes, lips, tongue, arms, or legs
- difficulty breathing
- congestive heart failure (CHF). Tell your healthcare provider right away if you experience any of the following symptoms of CHF:
- sudden weight gain
- worsening shortness of breath
- increased swelling of your feet, legs, or abdomen
- needing to use more pillows to go to sleep or sleeping in a recliner
- waking from sleep to catch your breath
- a cough that does not go away
- new or increasing irregularities in your heart rate
- abnormal heart rate or extra beats (arrhythmia). Your healthcare provider will be monitoring your heart while taking this medication. Report any feelings of rapid or racing heart rate immediately to your healthcare provider.
- a decline in liver function. Tell your healthcare provider any signs or symptoms of liver damage, which include the following:
- loss of appetite or start losing weight (anorexia)
- nausea or vomiting
- feel tired
- stomach pain or tenderness
- dark urine or light colored stools
- yellowing of your skin or the whites of your eyes
- fever or rash
- a decline in kidney function. Toxicity from milrinone may occur with kidney dysfunction. Your doctor may want to monitor your kidney function with certain blood tests as well. Tell your healthcare provider right away right away if you have any of the following symptoms of kidney dysfunction:
- swelling of face, ankles, hands, or feet
- paleness of skin
- decreased urination
- shortness of breath
- change in blood pressures
- side effects as mentioned in this section or in the “Side Effects” section of this medication page
- loss of control of blood sugar. Milrinone is mixed with dextrose, a type of sugar, before it is given into the vein (IV). This may result in low blood sugar episodes, high blood sugar episodes, or both. Tell your healthcare provider right away if you have some or all of the following symptoms of low blood sugar:
- difficulty speaking
- feeling anxious or weak
Tell your healthcare provider right away if you have some or all of the following symptoms of high blood sugar:
- increased thirst
- frequent urination
- weight loss
Milrinone can cause drowsiness. Do not drive or operate heavy machinery until you know how this medication affects you.
Milrinone Food Interactions
Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of milrinone, there are no specific foods that you must exclude from your diet when receiving this medication.
Before taking milrinone, tell your doctor about all of your medical conditions. Especially tell your doctor if you:
- are allergic to any ingredient in milrinone
- have or have had kidney problems
- have or have had liver problems
- have or have had problems with swelling or excess water
- are diabetic or hypoglycemic (have problems with your blood sugars)
- are pregnant or breastfeeding
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Milrinone and Pregnancy
Tell your doctor if you are pregnant or plan to become pregnant.
Milrinone and Lactation
Tell your doctor if you are breastfeeding or plan to breastfeed.
Take milrinone exactly as prescribed.
Milrinone comes in injectable form to be given directly into the vein (IV) by a healthcare professional.
Take milrinone exactly as prescribed by your doctor.
- the condition being treated
- other medical conditions you have
- other medications you are taking
- how you respond to this medication
- your kidney function
- your liver function
- your weight
The recommended dose range for milrinone in adults is based on weight and start with a large dose (loading dose) followed by a lower continuous dose. The recommended loading dose is 50 mcg/kg given in the vein (IV) over 10 minutes. After the loading dose, the dose ranges from 0.375 to 0.75 mcg/kg/minute given in the vein (IV) continuously (24 hours per day).
Milrinone is usually administered by a healthcare provider in a medical setting making it unlikely for an overdose to occur. However, if overdose is suspected, seek emergency medical attention.