Marcaine

Marcaine is used as a local or regional anesthetic for various procedures. Its safety and effectiveness depend on proper dosage, correct administration, and readiness for emergencies.

Marcaine Overview

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Marcaine is a prescription medication used to prevent pain and induce spinal anesthesia.

Marcaine belongs to a group of drugs called local or regional anesthetics. These work by numbing one small area of the body (local) or blocking pain in an area of the body (regional).

This medication is available in an injectable form to be administered by injection via local infiltration, peripheral nerve block, or caudal and lumbar blocks by a healthcare professional.

Common side effects of Marcaine include nausea, constipation, vomiting, and chills.

Marcaine can also cause blurred vision, drowsiness, and dizziness. Do not drive or operate heavy machinery until you know how Marcaine affects you.

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Marcaine Cautionary Labels

precautions

Uses of Marcaine

Marcaine is a prescription medication used to prevent pain before surgical procedures and induce spinal anesthesia.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Marcaine Drug Class

Marcaine is part of the drug class:

Side Effects of Marcaine

Serious side effects have been reported with Marcaine. See the “Marcaine Precautions” section.

Common side effects of Marcaine include the following:

  • nausea
  • constipation
  • vomiting
  • chills
  • low blood pressure
  • dizziness
  • blurred vision
  • ringing in the ears
  • anxiety
  • tremors

This is not a complete list of Marcaine side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Marcaine Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • Monoamine oxidase inhibitors such as rasagiline (Azilect), selegiline (Deprenyl, Eldepryl, Emsam), isocarboxazid (Marplan), isoniazid (Laniazid), phenelzine (Nardil)
  • Tricyclic antidepressants such as nortriptyline (Pamelor), amitriptyline, and imipramine (Tofranil)

This is not a complete list of Marcaine drug interactions. Ask your doctor or pharmacist for more information.

Marcaine Precautions

Serious side effects have been reported with Marcaine including the following:

  • Allergic-type reactions. Tell your healthcare provider right away if you have some or all of the following symptoms of allergic-type reactions.
    • Itching, hives, and redness
    • Swelling of the throat or face
    • Increased heart rate
    • Sneezing
    • Nausea
    • Vomiting
    • Dizziness
    • Loss of consciousness
    • Excessive sweating
    • Elevated temperature or fever
  • Neurologic reactions. Tell your healthcare provider right away if you have some or all of the following symptoms of neurologic reactions.
    • Decreased heart rate
    • Urinary retention
    • Fecal and urinary incontinence
    • Persistent anesthesia
    • Tingling in the extremities
    • Weakness
    • Paralysis of the lower extremities
    • Headache
    • Backache
    • Septic meningitis (inflammation of the brain and spinal cord)

Marcaine can cause drowsiness, dizziness, and blurred vision. Do not drive or operate heavy machinery until you know how Marcaine affects you.

Do not take Marcaine if you:

  • are allergic to Marcaine or to any of its ingredients

Marcaine injection should not be used in obstetrical paracervical block (local anesthetic injection around cervix) anesthesia.

Marcaine Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Marcaine, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Marcaine, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Marcaine or to any of its ingredients
  • have or have had liver problems
  • have or have had heart problems
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Marcaine and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Marcaine falls into category C.  In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Marcaine and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Marcaine has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from Marcaine, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

Marcaine Usage

This medication is available in an injectable form to be administered by injection via local infiltration, peripheral nerve block, or caudal and lumbar blocks by a healthcare professional. The dose, frequency, and route of administration will vary, depending on the indication for use.

Marcaine Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your weight
  • your height
  • your age
  • your gender

The dose, frequency, and route of administration will vary, depending on the indication for use.

Marcaine Overdose

If Marcaine is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Local anesthetics, including Marcaine, should only be administered by clinicians who are experienced in the diagnosis and management of dose-related toxicity and acute emergencies that might arise from the agent being used.
  • Emergency resuscitative equipment and personnel should be available when local anesthetics are administered.

Marcaine FDA Warning

THE 0.75% CONCENTRATION OF MARCAINE IS NOT RECOMMENDED FOR OBSTETRICAL ANESTHESIA. THERE HAVE BEEN REPORTS OF CARDIAC ARREST WITH DIFFICULT RESUSCITATION OR DEATH DURING USE OF MARCAINE FOR EPIDURAL ANESTHESIA IN OBSTETRICAL PATIENTS. IN MOST CASES, THIS HAS FOLLOWED USE OF THE 0.75% CONCENTRATION. RESUSCITATION HAS BEEN DIFFICULT OR IMPOSSIBLE DESPITE APPARENTLY ADEQUATE PREPARATION AND APPROPRIATE MANAGEMENT. CARDIAC ARREST HAS OCCURRED AFTER CONVULSIONS RESULTING FROM SYSTEMIC TOXICITY, PRESUMABLY FOLLOWING UNINTENTIONAL INTRAVASCULAR INJECTION. THE 0.75% CONCENTRATION SHOULD BE RESERVED FOR SURGICAL PROCEDURES WHERE A HIGH DEGREE OF MUSCLE RELAXATION AND PROLONGED EFFECT ARE NECESSARY.