Linzess helps relieve constipation of irritable bowel syndrome (IBS) by speeding up movement of intestinal contents. It is not suitable for children or people with certain allergies.

Linzess Overview


Linzess is a prescription medicine used in adults to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). 

Linzess belongs to a group of drugs called guanylate cyclase-C (GC-C) agonists, which stimulate the intestines to move food through the body faster.

This medication comes in the form of a capsule and is usually taken once daily, before breakfast.
Common side effects include diarrhea, gas, and stomach-area pain.

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Uses of Linzess

Linzess is a prescription medication used in adults to treat:

  • irritable bowel syndrome with constipation (IBS-C)  
  • a type of constipation called chronic idiopathic constipation (CIC).  “Idiopathic” means the cause of the constipation is unknown.  
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.


Linzess Drug Class

Linzess is part of the drug class:

Side Effects of Linzess

Linzess can cause serious side effects. See “Drug Precautions”.

  • Diarrhea is the most common side effect of Linzess, and it can sometimes be severe. 
  • Diarrhea often begins within the first 2 weeks of Linzess treatment.  
  • Stop taking Linzess and call your doctor right away if you get severe diarrhea during treatment with Linzess. 
Other common side effects of Linzess include: 
  • gas 
  • stomach-area (abdomen) pain 
  • swelling, or a feeling of fullness or pressure in your abdomen (distention)  
Tell your doctor if you have any side effect that bothers you or that does not go away. 
These are not all the possible side effects of Linzess. For more information, ask your doctor or pharmacist.   
In addition, call your doctor or go to the nearest hospital emergency room right away, if you develop unusual or severe stomach-area (abdomen) pain, especially if you also have bright red, bloody stools or black stools that look like tar. 
Call your doctor for medical advice about side effects.  You may report side effects to the FDA at 1-800-FDA­-1088. 

Linzess Interactions

No drug interactions have been studied by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Linzess Precautions

  • Do not give Linzess to children who are under 6 years of age. It may harm them. Avoid use in children 6 to 17 years old. 
  • Do not take Linzess if a doctor has told you that you have a bowel blockage (intestinal obstruction). 

Linzess Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Linzess, there are no specific foods that you must exclude from your diet when receiving this medication.


Inform MD

Before you take Linzess, tell your doctor if you: 

  • have any other medical conditions 
  • are pregnant or plan to become pregnant. It is not known if Linzess will harm your unborn baby. 
  • are breastfeeding or plan to breastfeed. It is not known if Linzess passes into your breast milk. Talk with your doctor about the best way to feed your baby, if you take Linzess. 
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements.  

Linzess and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Linzess falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.


Linzess and Lactation

It is not known if Linzess crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Linzess.


Linzess Usage

  • Take Linzess exactly as your doctor tells you to take it. 
  • Take Linzess one time each day on an empty stomach, at least 30 minutes before your first meal of the day. 
  • Swallow Linzess capsules whole. Do not break or chew the capsules.
  • If you miss a dose, skip the missed dose. Just take the next dose at your regular time. Do not take 2 doses at the same time.

Linzess Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The recommended dose of Linzess for the treatment of irritable bowel syndrome with constipation is 290 mcg taken orally once daily.

The recommended dose of Linzess for the treatment of chronic idiopathic constipation is 145 mcg taken orally once daily.

Linzess Overdose

If you take too much Linzess, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

Store Linzess at room temperature between 68°F to 77°F (20°C to 25°C). 

  • Keep Linzess in the bottle that it comes in. The Linzess bottle contains a desiccant packet to help keep your medicine dry (protect it from moisture). Do not remove the desiccant packet from the bottle. 
  • Keep the container of Linzess tightly closed and in a dry place. 
  • Keep Linzess and all medicines out of the reach of children. 

Linzess FDA Warning


Linzess is contraindicated in pediatric patients up to 6 years of age. Avoid use in pediatric patients 6 through 17 years of age. In nonclinical studies, administration of a single, clinically relevant adult oral dose of Linzess caused deaths in young juvenile mice.