Lexiva

Lexiva treats HIV. Many medications can interact with Lexiva, so inform all of your healthcare providers if you take this medication.

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Pharmacist Anyssa Garza, PharmD overviews usage and side effects of Lexiva.
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Lexiva Overview

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Lexiva is a prescription medication to treat human immunodeficiency virus (HIV) infection. Lexiva belongs to a group of drugs called protease inhibitors. It works by decreasing the amount of HIV in the blood.

This medication comes in tablet and liquid forms and is usually taken twice daily, with or without food.

Common side effects include nausea, vomiting, and diarrhea.

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Lexiva Cautionary Labels

precautionsprecautionsprecautions

Uses of Lexiva

Lexiva is a prescription medicine used to treat HIV infection. HIV is the virus that causes AIDS (acquired immune deficiency syndrome). Lexiva is always used with other anti-HIV medicines.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Lexiva Drug Class

Lexiva is part of the drug class:

Side Effects of Lexiva

Serious side effects have been reported. See "Drug Precautions" section.

Common side effects of Lexiva are nausea, vomiting, and diarrhea. Tell your healthcare provider about any side effects that bother you or that won't go away.

This list of side effects of Lexiva is not complete. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Lexiva Interactions

Lexiva can cause dangerous and life-threatening interactions if taken with certain other medicines. Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Do not take the following medicines with Lexiva:

  • Halcion (triazolam; used for insomnia)
  • Ergot medicines: dihydroergotamine, ergonovine, ergotamine, and methylergonovine such as Cafergot, Migranal, D.H.E. 45, ergotrate maleate, Methergine, and others (used for migraine headaches)
  • Propulsid (cisapride), used for certain stomach problems
  • Versed (midazolam), used for sedation
  • Orap (pimozide), used for Tourette’s disorder
  • Revatio (sildenafil), used for treatment of pulmonary arterial hypertension
  • Uroxatral (alfuzosin), used for benign prostatic hyperplasia (BPH)

You should not take Agenerase (amprenavir) and Lexiva at the same time.

There are other medicines you should not take if you are taking Lexiva and Norvir (ritonavir) together. You could develop serious or life-threatening problems. Tell your healthcare provider about all medicines you are taking before you begin taking Lexiva and Norvir (ritonavir) together.

Women who use birth control pills should choose a different kind of contraception. The use of Lexiva with Norvir (ritonavir) in combination with birth control pills may be harmful to your liver. The use of Lexiva with or without Norvir may decrease the effectiveness of birth control pills. Talk to your healthcare provider about choosing an effective contraceptive.

Lexiva Precautions

Lexiva may cause the following side effects:

  • skin rash. Skin rashes, some with itching, have happened in patients taking Lexiva. Swelling of the face, lips, and tongue (angioedema) has also been reported. Tell your healthcare provider if you get a rash or develop facial swelling after starting Lexiva.
  • diabetes and high blood sugar (hyperglycemia). Some patients had diabetes before taking Lexiva while others did not. Some patients may need changes in their diabetes medicine. Others may need a new diabetes medicine.
  • increased bleeding problems in some patients with hemophilia.
  • worse liver disease. Patients with liver problems, including hepatitis B or C, are more likely to get worse liver disease when they take anti-HIV medicines like Lexiva.
  • changes in blood tests. Some people have changes in blood tests while taking Lexiva. These include increases seen in liver function tests and blood fat levels, and decreases in white blood cells. Your healthcare provider may do regular blood tests to see if Lexiva is affecting your body.
  • changes in body fat. These changes have happened in patients taking antiretroviral medicines like Lexiva. The changes may include an increased amount of fat in the upper back and neck ("buffalo hump"), breast, and around the trunk. Loss of fat from the legs, arms, and face may also happen. The cause and long-term health effects of these conditions are not known at this time.
  • kidney stones have been reported in some patients taking Lexiva. If you develop signs or symptoms of kidney stones (pain in your side, blood in your urine, pain when you urinate) tell your healthcare provider right away.

Do not take Lexiva if you:

Avoid doing things that can spread HIV infection since Lexiva doesn't stop you from passing the HIV infection to others.

  • Do not share needles or other injection equipment.
  • Do not share personal items that can have blood or body fluids on them, like toothbrushes or razor blades.
  • Do not have any kind of sex without protection. Always practice safer sex by using a latex or polyurethane condom to lower the chance of sexual contact with semen, vaginal secretions, or blood.

Lexiva Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Lexiva there are no specific foods that you must exclude from your diet when receiving this medication.
 

Inform MD

Before taking Lexiva, tell your healthcare provider about all of your medical conditions including if you:

  • are pregnant or breastfeeding
  • have liver problems
  • have kidney problems
  • have diabetes
  • have hemophilia
  • are allergic to sulfa medicines

Before taking Lexiva, tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. 

Lexiva and Pregnancy

Tell your healthcare provider if you are pregnant or planning to become pregnant. It is not known if Lexiva can harm your unborn baby. You and your healthcare provider will need to decide if Lexiva is right for you. If you use Lexiva while you are pregnant, talk to your healthcare provider about how you can be on the Antiretroviral Pregnancy Registry.

Women who use birth control pills should choose a different kind of contraception. The use of Lexiva with NORVIR (ritonavir) in combination with birth control pills may be harmful to your liver. The use of Lexiva with or without NORVIR may decrease the effectiveness of birth control pills. Talk to your healthcare provider about choosing an effective contraceptive.

Lexiva and Lactation

Tell your healthcare provider if you are breastfeeding. You should not breastfeed if you are HIV-positive because of the chance of passing the HIV virus to your baby through your milk. Also, it is not known if Lexiva can pass into your breast milk and if it can harm your baby. If you are a woman who has or will have a baby, talk with your healthcare provider about the best way to feed your baby.

Lexiva Usage

  • Take Lexiva exactly as your healthcare provider prescribed.
  • Do not take more or less than your prescribed dose of Lexiva at any one time. Do not change your dose or stop taking Lexiva without talking with your healthcare provider.
  • You can take Lexiva tablets with or without food.
  • Adults should take Lexiva oral suspension without food.
  • Pediatric patients should take Lexiva oral suspension with food. If vomiting occurs within 30 minutes after dosing, the dose should be repeated.
  • Shake Lexiva oral suspension vigorously before each use.
  • When your supply of Lexiva or other anti-HIV medicine starts to run low, get more from your healthcare provider or pharmacy. The amount of HIV virus in your blood may increase if one or more of the medicines are stopped, even for a short time.
  • Stay under the care of a healthcare provider while using Lexiva.
  • It is important that you do not miss any doses. If you miss a dose of Lexiva by more than 4 hours, wait and take the next dose at the regular time. However, if you miss a dose by fewer than 4 hours, take your missed dose right away. Then take your next dose at the regular time.

Lexiva Dosage

Lexiva Dosage for Adult Patients
If you have never taken a protease inhibitor, your doctor may recommend one of the following dosing regimens:
 
  • Lexiva 1400 mg twice daily (without Norvir)
  • Lexiva 1400 mg once daily and Norvir 200 mg once daily
  • Lexiva 1400 mg once daily and Norvir 100 mg once daily
  • Lexiva 700 mg twice daily and Norvir 100 mg twice daily.
     
If you have taken a protease inhibitor medication before, the recommended dose is Lexiva 700 mg twice daily and Norvir 100 mg twice daily.
 
If you have liver disease, your doctor will recommend a lower dosage based on the severity of your liver impairment.
 
Lexiva Dosage for Pediatric Patients (2 to 18 years of age)
Your child's doctor will recommend a Lexiva dosage based on your child's age and weight, taking into account whether or not the child has received protease inhibitors before, and if the child is receiving Norvir in addition to Lexiva.

Lexiva Overdose

If you take too much Lexiva, call your healthcare provider or poison control center right away.

Other Requirements

  • Lexiva tablets should be stored at room temperature between 59° and 86°F (15° to 30°C). Keep the container tightly closed.
  • Lexiva suspension may be stored at room temperature or refrigerated. Refrigeration may improve taste for some patients. Do not freeze.
  • Keep this and all medicines out of the reach of children.
  • Do not keep medicine that is out of date or that you no longer need. Be sure that if you throw any medicine away, it is out of the reach of children.