To avoid dangerous side effects from this medication, tobramycin must be closely monitored.
Tobramycin trough Overview
Tobramycin is an aminoglycoside antibiotic used to treat serious infections caused by aerobic, gram-negative bacilli and less serious topical infections of the skin and eye. Tobramycin is also used as an inhalation solution for the management of cystic fibrosis patients. Trough level is monitored mainly to avoid toxicity. Trough level is taken 30 minutes prior to the next dose after steady state has been reached (after 3rd dose).
Tobramycin trough is measured in micrograms/milliliters (mcg/ml).
The recommended tobramycin trough is less than or equal to 2 mcg/ml.
No preparation needed, but timing of the sample for testing is important.
Follow your doctor's directions.
What the results mean
Aminoglycosides may accumulate in the kidneys, increasing the risk of nephrotoxicity (kidney damage). This may relate to the amount of time tobramycin trough levels are >2 mcg/mL. Higher than normal trough values indicate an increased risk for nephrotoxicity and ototoxicity.