Kyprolis (generic: carfilzomib) is a prescription medication used to treat multiple myeloma (bone marrow cancer) in adults. Kyprolis belongs to a group of drugs called proteasome inhibitors, which stop or slow the growth of cancer cells.
This medication comes in an injectable form and is given directly into a vein (IV) by a healthcare provider. It is usually given 2 days in a row each week, for 3 weeks.
Common side effects of Kyprolis include tiredness, anemia, and nausea.
Kyprolis is a prescription medicine used for the treatment of multiple myeloma, a type of blood cancer, in people who have tried at least two other medicines, who are no longer responding to ongoing current treatments, or to a therapy that was stopped within the last 60 days.
Kyprolis can cause serious side effects. See "Drug Precautions".
The most common side effects in clinical studies were fatigue, low blood cell count and blood platelet levels, shortness of breath, diarrhea and fever; serious side effects included heart failure.
No Kyprolis drug interactions have been identified, however, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.
Serious side effects and death have occurred during Kyprolis treatment including:
- death due to cardiac arrest (the heart suddenly stops pumping)
- congestive heart failure (the heart isn't pumping enough blood to meet the needs of the body)
- pulmonary edema (excess fluid in the lungs)
- myocardial ischemia (bloodflow to heart is partially or completely blocked)
- pulmonary hypertension (a type of high blood pressure that affects the arteries in the lungs and the right side of the heart)
- lung complications
- infusion reactions (unexpected reactions ranging from mild to fatal in severity)
- Tumor Lysis Syndrome TLS (complications caused by the breakdown of cancer cells)
- thrombocytopenia (low platelet count)
- liver damage or failure
Call your doctor right away if you have any of the following symptoms:
- chest pain
- swelling of the feet or legs.
Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Kyprolis there are no specific foods that you must exclude from your diet when receiving Kyprolis.
Tell your doctor if you are allergic to Kyprolis or any other medicine.
Tell your doctor about all of your medical conditions including if you have heart, liver, or kidney disease.
Tell your doctor if you are pregnant or breastfeeding.
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Tell your doctor if you are pregnant or plan to become pregnant. You should not receive Kyprolis during pregnancy. Use effective birth control to avoid pregnancy during Kyprolis treatments. If you become pregnant during Kyprolis treatment, tell your doctor right away.
Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if Kyprolis is excreted in human breast milk or if it will harm your nursing baby.
Kyprolis comes as a liquid that is injected intravenously (into a vein). The injection takes 2 to 10 minutes, and must be given on two days in a row, each week for three weeks (Days 1, 2, 8, 9, 15, and 16), followed by a 12-day rest period (Days 17 to 28). Each 28-day period is considered one treatment cycle. Kyprolis treatments are given by a doctor or nurse at a medical facility (hospital or clinic).
The dose your doctor recommends is calculated based on your height and weight. You will likely receive IV fluids at the same time you receive your Kyprolis dose. Your doctor may prescribe another medicine called dexamethasone to be taken by mouth or injected into a vein before you receive doses of Kyprolis, especially during the first treatment cycle.
Kyprolis is usually administered by a healthcare provider in a medical setting making it unlikely for an overdose to occur. However, if overdose is suspected, seek emergency medical attention.
Keep all medical and laboratory appointments. To get the most benefit, you should receive Kyprolis doses as scheduled. If you miss an appointment, reschedule as soon as possible.