Invega has caused some rare, but serious side effects including Neuroleptic Malignant Syndrome (NMS), Tardive Dyskinesia (TD) and changes in heart rhythm. It has also been associated with high blood sugar and diabetes, changes in cholesterol and triglycerides, and weight gain. Invega and similar medicines have been associated with decreases in white blood cell counts.

Invega should be used with caution in people with a seizure disorder or those at increased risk for seizures.

Tell your doctor if you are allergic to Invega, risperidone (Risperdal) or any other medications.

Tell your doctor if you have heart problems.  If you have or have ever had a rare heart problem that may cause fainting or irregular heartbeat (prolonged QT interval) or a heart attack, you should tell your doctor before taking Invega.

Tell  your doctor if you have or have ever had any condition that causes blockage or narrowing of the esophagus, stomach, or intestines. Also tell your doctor if you have inflammatory bowel disease (IBD), and kidney or liver disease.

Tell your doctor if you are pregnant, planning to become pregnant or breastfeeding. Invega may harm your unborn baby or your nursing baby.

Invega may cause drowsiness. You should not drive a car or operate machinery until you know how it will affect you. You should not drink alcohol while on Invega. Alcohol may add to the drowsiness caused by Invega.

While taking Invega, you may experience increases in your blood sugar (hyperglycemia) even if you don't already have diabetes. You may be at an increased risk of developing diabetes if you take Invega or similar medicines.

Invega may make it harder for your body to cool down during exercise or in hot weather. 

Get out of bed slowly, resting your feet on the floor before standing, to avoid dizziness, lightheadedness, and fainting while taking Invega.