Intelence

Intelence is used in combination with other medications to treat HIV. This medication is used in people who have developed resistance to other HIV medications.

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Intelence Overview

Updated: 

Intelence is a prescription medication used in combination with other medications to treat human immunodeficiency virus (HIV) in people who are at least 6 years of age. Intelence is used when other medications have not been successful. Intelence is a type of HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI). It works by stopping HIV from dividing and spreading.

This medication comes in tablet form and is usually taken twice daily, after meals. Intelence must be swallowed whole with a glass of water.

Common side effects include tingling, numbness, or pain in the hands or feet, and diarrhea.

Patient Ratings for Intelence

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  • Other
  • Hiv Infections

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  • A month or so
  • A few months
  • A year or so
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Uses of Intelence

Intelence is a prescription medication used in combination with other medications to treat human immunodeficiency virus (HIV) in people who are at least 6 years of age. Intelence is given when other medications have not been successful.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

 

Manufacturer

Intelence Drug Class

Intelence is part of the drug class:

Side Effects of Intelence

Intelence can cause serious side effects. See "Drug Precautions" section.

In adults, common side effects of Intelence include tingling, numbness, or pain in the hands or feet.

In children, diarrhea is a common side effect of Intelence.

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects with Intelence. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Intelence Interactions

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements, including St. John's wort (Hypericum perforatum). Some medicines may interact with Intelence.

Intelence may affect the way other medicines work, and other medicines may affect how Intelence works. Taking Intelence and certain other medicines may cause serious side effects. If you take certain medicines with Intelence, then the amount of Intelence in your body may be too low and Intelence may not work to help reduce your HIV viral load. The HIV virus in your body may become resistant to Intelence or other HIV medicines that are like it.

Tell your doctor if you take other HIV medicines. Some HIV medicines should not be taken with Intelence.

Tell your doctor if you take:

  • an antiarrhythmic to treat abnormal heart rhythms-amiodarone (Cordarone, Pacerone), bepridil (Vascor), digoxin (Lanoxin), disopyramide (Norpace), flecainide (Tambocor), lidocaine (LidoPen, Xylocaine), mexiletine (Mexitil), propafenone (Rythmol SR), quinidine (Duraquin, Quinaglute)
  • an anticoagulant to prevent blood clots-warfarin (Coumadin)
  • an anti-seizure medicine to treat epilepsy or prevent seizures-carbamazepine (Tegretol, Tegretol-XR, Carbatrol, Equetro, Teril, Epitol), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin, Dilantin-125, Phenytek)
  • an antifungal to treat a fungal infection-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), voriconazole (Vfend)
  • an anti-infective to treat a bacterial infection-clarithromycin (Biaxin, Biaxin XL)
  • an antimycobacterial to treat a bacterial infection, including tuberculosis (TB)-rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate, Rimactane), rifapentine (Priftin)
  • a benzodiazepine to treat trouble with sleeping and/or anxiety-diazepam (Diastat, Valium)
  • a corticosteroid to treat inflammation or asthma-dexamethasone (Decadron)
  • an HMG-CoA reductase inhibitor to lower cholesterol levels-atorvastatin (Caduet, Lipitor), fluvastatin (Lescol), lovastatin (Advicor, Altoprev, Mevacor), pitavastatin (Livalo), rosuvastatin (Crestor), simvastatin (Juvisync, Simcor, Vytorin, Zocor)
  • an immunosuppressant to prevent organ transplant rejection-cyclosporine (Gengraf, Sandimmune, Neoral), sirolimus (Rapamune), tacrolimus (Prograf)
  • a medicine to treat narcotic withdrawal and dependence-buprenorphine (Buprenex, Butrans, Subutex), buprenorphine/naloxone (Suboxone), methadone (Dolophine, Methadose)
  • a PDE-5 inhibitor to treat erectile dysfunction and/or pulmonary arterial hypertension-sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), vardenafil (Levitra, Staxyn)
  • a platelet aggregation inhibitor to prevent blood clots-clopidogrel (Plavix)
  • dolutegravir (Tivicay)
  • atazanavir/ritonavir
  • boceprevir (Victrelis)

Dolutegravir should only be used with Intelence when co‑administered with atazanavir/ritonavir, darunavir/ritonavir, or lopinavir/ritonavir.

Ask your doctor or pharmacist if you are not sure if your medicine is one that is listed above.

Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.

Your doctor and your pharmacist can tell you if you can take these medicines with Intelence. Do not start any new medicines while you are taking Intelence without first talking with your doctor or pharmacist. You can ask your doctor or pharmacist for a list of medicines that can interact with Intelence.

Intelence Precautions

Intelence can cause serious side effects including:

  • Severe skin rash and allergic reactions. Skin rash is a common side effect of Intelence. Rash can be serious. Call your doctor right away if you get a rash. In some cases, severe rash and allergic reaction may need to be treated in a hospital and may potentially lead to death.
    If you get a rash with any of the following symptoms, stop taking Intelence and call your doctor or get medical help right away:
    • hives or sores in your mouth, or your skin blisters and peels
    • trouble swallowing or breathing
    • swelling of your face, eyes, lips, tongue, or throat
    • fever, yellowing of the skin or whites of the eyes, dark urine, or pain on the right side of the stomach-area (abdominal pain).
  • Changes in body fat can happen in people taking HIV medicines. These changes may include an increased amount of fat in the upper back and neck ("buffalo hump"), breast, and around the middle of your body (trunk). Loss of fat from the legs, arms, and face may also happen. The exact cause and long-term health effects of these problems are not known.
  • Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. Call your doctor right away if you start having any new symptoms after starting your HIV medicine.

Avoid doing things that can spread HIV-1 infection to others:

  • Do not share or re-use needles or other injection equipment.
  • Do not share personal items that can have blood or body fluids on them, like toothbrushes and razor blades.
  • Do not have any kind of sex without protection. Always practice safe sex by using a latex or polyurethane condom to lower the chance of sexual contact with semen, vaginal secretions, or blood.

Ask your doctor if you have any questions on how to prevent passing HIV to other people.

Intelence Food Interactions

Avoid using grapefruit juice or warm (more than 104°F or 40°C) or carbonated beverages when taking this medication.

Inform MD

Before taking Intelence tell your doctor if you:

  • have had or currently have liver problems, including hepatitis B or C.
  • have any other medical conditions.
  • are pregnant or breastfeeding.

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Intelence and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Intelence falls into category B. There are no well-done studies that have been done in humans with Intelence. But in animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

Pregnancy Registry: There is a pregnancy registry for women who take antiviral medicines during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your doctor about how you can take part in this registry.

Intelence and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed. Do not breastfeed if you take Intelence. You should not breastfeed if you have HIV because of the risk of passing HIV to your baby. Talk with your doctor about the best way to feed your baby.

Intelence Usage

  • Stay under the care of your doctor during treatment with Intelence.
  • Take Intelence tablets every day exactly as prescribed by your doctor.
  • Your doctor will tell you how many Intelence tablets to take and when to take them. Talk to your doctor if you have questions about when to take Intelence.
  • Intelence is taken two times each day. If your child takes Intelence, your doctor will prescribe the right dose based on your child's weight.
  • Always take Intelence following a meal. Do not take Intelence on an empty stomach. Intelence may not work as well if you take it on an empty stomach.
  • Do not change your dose or stop taking Intelence without first talking with your doctor. See your doctor regularly while taking Intelence.
  • Swallow Intelence whole, with a glass of water. Do not chew the tablet(s).

If you are unable to swallow Intelence tablets whole, you may take your dose of Intelence as follows:

  • Step 1: Measure approximately 5 mL (1 teaspoon) of water and pour into a cup.
  • Step 2: Place the tablets in the cup containing 5 mL of water. If needed, add more water to cover the tablets. Do not put the tablets in other liquids.
  • Step 3: Stir well until the water looks milky.
  • Step 4: At this step, you may add a small amount of water, orange juice or milk to make it easier to take.
  • Step 5: Drink right away.
  • Step 6: Add more water, orange juice or milk to the cup to rinse the cup several times and completely swallow each time to make sure you take your entire dose of Intelence.
 
  • Avoid using grapefruit juice or warm (more than 104°F or 40°C) or carbonated beverages when taking Intelence tablets.
  • When your supply of Intelence starts to run low, get more from your doctor or pharmacy. It is important not to run out of Intelence. The amount of HIV in your blood may increase if the medicine is stopped even for a short time.
  • If you miss a dose of Intelence within 6 hours of the time you usually take it, take your dose of Intelence following a meal as soon as possible. Then, take your next dose of Intelence at the regularly scheduled time. If you miss a dose of Intelence by more than 6 hours of the time you usually take it, wait and then take the next dose of Intelence at the regularly scheduled time.
  • Do not take more than your prescribed dose to make up for a missed dose.

Intelence Dosage

The recommended oral Intelence dose is 200 mg (one 200 mg tablet or two 100 mg tablets) taken twice daily following a meal.

The recommended dose for patients 6 years to less than 18 years of age and weighing at least 16 kg is based on body weight, not exceeding the recommended adult dose of 200 mg taken twice daily. The dose for children 6 years to less than 18 years of age ranges from 100 mg to 200 mg taken twice daily.

Intelence Overdose

If you take too much Intelence, contact your local poison control center or go to the nearest emergency room right away.

Other Requirements

  • Store at 59°F to 86°F (15°C to 30°C).
  • Keep Intelence in the original bottle given to you by your pharmacist. After opening, keep the bottle tightly closed to protect this medication from moisture.

Keep this and all medicines out of the reach of children.