Exjade helps lower iron levels in people with too much iron in their blood caused by frequent blood transfusions.

Exjade Overview


Exjade is a prescription medication used to remove the extra iron that builds up in people who receive repeated blood transfusions and in people with an inherited blood disorder called non-transfusion-dependent thalassemia (NTDT). Exjade belongs to a group of drugs called iron chelators. It works by attaching to iron in the body so that it can be removed from the body in feces.

This medication comes in a tablet to be dissolved in liquid. It is taken by mouth on an empty stomach (at least 30 minutes before eating), once daily.

Common side effects of Exjade include nausea, vomiting, diarrhea, and stomach pain. Exjade can cause dizziness. Do not drive or operate heavy machinery until you know how it affects you.

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Exjade Cautionary Labels


Uses of Exjade

Exjade is a prescription medication used for the treatment of chronically (long-lasting) elevated iron blood levels caused by:

  • repeated blood transfusions in patients 2 years of age and older
  • a genetic blood disorder called non-transfusion-dependent thalassemia (NTDT) in patients 10 years of age and older

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.


Exjade Drug Class

Exjade is part of the drug class:

Side Effects of Exjade

Serious side effects have been reported. See "Drug Precautions" section.

Common side effects include:

  • nausea
  • vomiting
  • diarrhea
  • stomach pain
  • increases in kidney laboratory values
  • skin rash

​This is not a complete list of Exjade side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Exjade Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • other iron chelating agents
  • birth control pills and other hormonal contraceptive medications
  • diabetes medications
  • seizure medications such as phenytoin (Dilantin) and phenobarbital (Luminal)
  • cholesterol-lowering drugs such as simvastatin (Zocor, in Simcor, in Vytorin)
  • cholestyramine (Questran, Prevalite)
  • colesevelam (Welchol)
  • colestipol (Colestid)
  • aluminum-containing antacids such as Amphogel, Alternagel, Gaviscon, Maalox, or Mylanta
  • cyclosporine (Gengraf, Neoral, Sandimmune)
  • repaglinide (Prandin, in Prandimet)
  • ritonavir (Norvir)
  • anticoagulants ("blood thinners") such as warfarin (Coumadin, Jantoven)
  • bisphosphonates such as alendronate (Fosamax), ibandronate (Boniva), risedronate (Actonel, Atelvia), and others
  • rifampin (Rimactane, Rifadin)

This is not a complete list of Exjade drug interactions. Ask your doctor or pharmacist for more information.

Exjade Precautions

Exjade may cause serious kidney problems, liver problems, and bleeding in the stomach or intestines. In some cases, these problems were fatal. Kidney problems occurred particularly in patients with multiple medical conditions and those who were very ill because of their disease. Bleeding in the stomach or intestines occurred more often in elderly patients. Liver problems were more likely to happen in patients older than 55 years.

Your doctor should check your kidneys with a blood test called serum creatinine and/or creatinine clearance:

  • Before taking Exjade 
  • Monthly during treatment

If you already have a history of kidney problems or are at risk for kidney problems, your doctor should check your kidneys:

  • Every week for the first month
  • Monthly during treatment

Your doctor should check your liver with blood tests called serum transaminases and bilirubin:

  • Before taking Exjade 
  • Every other week for the first month after starting Exjade 
  • Monthly during treatment

Other serious side effects can occur including:

Blood Disorders. Some patients developed severe blood disorders, in some cases fatal, while on Exjade therapy. Having a pre-existing blood disorder may increase the risk. Your doctor will give you a blood test to check your blood counts.

Increased Risks When Used in Elderly PatientsSince Exjade has been on the market, there have been reports of serious reactions, sometimes leading to death. These serious reactions and deaths have happened most often when Exjade was taken by elderly patients.

Allergic ReactionsSerious allergic reactions (which include swelling of the throat) have been reported in patients taking Exjade, usually within the first month of treatment. If you develop swelling of the throat, a severe rash, hearing problems, or vision disturbances, stop taking Exjade and contact your doctor immediately.

Serious RashA skin disorder that results in a very serious rash, called erythema multiforme, has been reported during treatment with Exjade. If you develop a severe rash, stop taking Exjade and contact your doctor immediately.

Hearing and Vision ChangesChanges to hearing and vision have been reported in patients taking Exjade . If you notice changes in your hearing or eyesight, contact your doctor immediately. You may also receive a hearing or vision test prior to receiving Exjade and yearly thereafter. Your doctor may change your dose based on the results of these tests.

Do not take Exjade if you have:

  • Certain kinds of kidney problems
  • Pre-existing severe liver problems
  • High-risk myelodysplastic syndromes (MDS)
  • Advanced cancer
  • Low blood counts (low platelets)
  • An allergy to any ingredient in this medication

Exjade Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Exjade, there are no specific foods that you must exclude from your diet when receiving this medication.


Inform MD

Before taking Exjade, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Exjade or any ingredient of Exjade
  • have kidney problems
  • have severe liver problems
  • have high-risk myelodysplastic syndromes (MDS)
  • have advanced cancer
  • have low blood platelet counts

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Exjade and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Exjade falls into category C. In animals studies, pregnant animals were given this medication and had some babies born with problems. There are no well-controlled studies that have been done in humans with Exjade, though. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Exjade and Lactation

It is not known if Exjade crosses into human milk, although Exjade is passed through breast milk in animals. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Exjade.

Exjade Usage

Take Exjade exactly as prescribed.

Exjade comes as a tablet for suspension (a tablet to dissolve in liquid) to take by mouth.

Do not chew or swallow the tablets whole. Always dissolve the tablets in liquid (water, apple juice, or orange juice) before taking them as follows:

  • Drop your Exjade tablet(s) into a glass of orange juice, apple juice, or water. You can also use the Exjade mixer each day when taking your Exjade. Make sure that you use the amount of liquid directed by your doctor.
  • Stir the liquid and Exjade tablet(s) until you have an even mixture. The consistency of the mixture may be thick.
  • Drink all of the Exjade mixture. Add more juice or water to mix anything that's left over. And then drink that.

Exjade should be taken on an empty stomach once daily, at least 30 minutes before eating.

Take Exjade at the same time every day.

Do not take more or less of it or take it more often than prescribed by your doctor.

Exjade Dosage

Take Exjade exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The Exjade dose your doctor recommends will be based on:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your weight

Transfusional Iron Overload

The recommended starting dose of Exjade for patients 2 years of age and older is 20 mg per kg body weight by mouth, once daily. Doses are calculated to the nearest whole tablet.
Doses above 40 mg per kg are not recommended.
Iron Overload in Non-Transfusion Dependent Thalassemia Syndromes
The recommended starting dose of Exjade is 10 mg per kg body weight by mouth once daily (to the nearest whole tablet).


Exjade Overdose

If you take too much Exjade call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store at room temperature between 15–30°C (59–86°F).
  • Keep this and all medications out of the reach of children.

Exjade FDA Warning


Renal Failure

  • Exjade can cause acute renal failure and death, particularly in patients with comorbidities and those who are in the advanced stages of their hematologic disorders.
  • Measure serum creatinine and determine creatinine clearance in duplicate prior to initiation of therapy and monitor renal function at least monthly thereafter. For patients with baseline renal impairment or increased risk of acute renal failure, monitor creatinine weekly for the first month, then at least monthly. Consider dose reduction, interruption, or discontinuation based on increases in serum creatinine.

Hepatic Failure

  • Exjade can cause hepatic injury including hepatic failure and death.
  • Measure serum transaminases and bilirubin in all patients prior to initiating treatment, every 2 weeks during the first month, and at least monthly thereafter.
  • Avoid use of Exjade in patients with severe (Child-Pugh C) hepatic impairment and reduce the dose in patients with moderate (Child Pugh B) hepatic impairment. 

Gastrointestinal Hemorrhage

  • Exjade can cause gastrointestinal (GI) hemorrhages, which may be fatal, especially in elderly patients who have advanced hematologic malignancies and/or low platelet counts.
  • Monitor patients and discontinue Exjade for suspected GI ulceration or hemorrhage.