Estradiol and Norethindrone

relieves symptoms associated with menopause. Re-evaluate with your doctor every 3 to 6 months about the dose you are taking and whether you still need this medication.

Estradiol and Norethindrone Overview

Reviewed: August 7, 2015

Estradiol/norethindrone is a prescription medication used after menopause to reduce moderate to severe hot flashes, treat moderate to severe menopausal changes in and around the vagina, and help reduce your chances of getting osteoporosis (thin weak bones). It is also used to treat certain conditions in women before menopause if their ovaries do not make enough estrogens naturally. 

This medication contains two hormones, estradiol and norethindrone, and belongs to a group of drugs called estrogen and progestin combinations. Together these work as a hormone replacement to relieve issues caused by hormonal changes. 

This medication comes in a tablet form and is usually taken once daily, with or without food. 

It is also available as a patch and is usually applied 2 times each week or every 3 to 4 days.

Common side effects of this medication include headache, breast pain, and irregular vaginal bleeding or spotting. 

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Estradiol and Norethindrone Brand Names

Estradiol and Norethindrone may be found in some form under the following brand names:

Estradiol and Norethindrone Drug Class

Estradiol and Norethindrone is part of the drug class: