Epivir treats HIV infection. Do not stop taking Epivir unless your doctor tells you otherwise. Do not miss any doses. Stopping medication and missing doses can make it harder to treat HIV.

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Pharmacist Walker Winn, PharmD overviews usage and side effects of Epivir.
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Pharmacist Walker Winn, PharmD overviews usage and side effects of Epivir.
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Epivir Overview


Epivir is a prescription medication used to treat human immunodeficiency virus (HIV) infections in adults and children. Epivir belongs to a group of drugs called nucleoside reverse transcriptase inhibitors (NRTI), which block a process HIV virus needs to reproduce.

This medication comes in tablet and oral liquid forms and is taken once or twice a day, with or without food.

Some of the common side effects of Epivir include headache, ill feeling, and fatigue. 

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  • Other
  • Acquired Immunodeficiency Syndrome
  • Hepatitis B
  • Hiv Infections

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Epivir Cautionary Labels


Uses of Epivir

Epivir is a prescription medicine used to treat human immunodeficiency virus (HIV) infections in adults and children. Epivir does not cure HIV infections or acquired immune deficiency syndrome (AIDS). 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information. 


Epivir Drug Class

Side Effects of Epivir

Serious side effects can occur with Epivir use. See "Epivir Precautions" section.

Commonly reported side effects include:

  • headache
  • ear, nose or throat infections
  • malaise (general ill feeling) and fatigue
  • nausea
  • diarrhea
  • cough
  • fever
  • chills
  • muscle and joint pain

This is not a complete list of Epivir side effects. Ask your doctor or pharmacist for more information.

Epivir Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • interferon medications
  • emtricitabine
  • zalcitabine (Hivid)
  • trimethoprim/sulfamethoxazole (Bactrim, Septra), an antibiotic

Ask your doctor if you are unsure if you are taking any of these medications.

This is not a complete list of Epivir drug interactions. Ask your doctor or pharmacist for more information.

Epivir Precautions

Some severe side effects have been reported with Epivir use including the following:

Lactic Acidosis/Severe Hepatomegaly With Steatosis. Epivir can cause serious damage to the liver and a condition called lactic acidosis. If you experience any of the following symptoms, call your doctor immediately: 

  • nausea
  • loss of appetite
  • excessive tiredness
  • weakness
  • dark yellow or brown urine
  • unusual bleeding or bruising
  • flu-like symptoms
  • yellowing of the skin or eyes
  • pain in the upper right part of your stomach

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Epivir.

Pancreatitis. Epivir can cause life-threatening inflammation of the pancreas (pancreatitis). Tell your doctor immediately if you have any signs of pancreatitis, such as:

  • fast heart rate 
  • short, quick breaths
  • nausea and vomiting
  • fever
  • swollen, tender abdomen (stomach area)

Fat Redistribution. Epivir can change the distribution of fat on your body. You may gain fat in areas such as in the abdomen or at the back of the neck (a "buffalo hump"), and may lose weight in other areas.

Do not take Epivir if you:

  •  are allergic to Epivir or to any of its ingredients
  • are taking other medications containing lamivudine
  • are taking emtricitabine 

Information About Therapy With Epivir: Epivir is not a cure for HIV-1 infection and patients may continue to experience illnesses associated with HIV-1 infection, including opportunistic infections. Patients should remain under the care of a physician when using Epivir.

Patients should be advised that the use of Epivir has not been shown to reduce the risk of transmission of HIV-1 to others through sexual contact or blood contamination. Epivir does not stop you from spreading HIV-1 to others by sex, sharing needles, or being exposed to your blood. Avoid doing things that can spread HIV-1 infection to others.

  • Do not share or re-use needles or other injection equipment.
  • Do not share personal items that can have blood or body fluids on them, like toothbrushes and razor blades.
  • Do not have any kind of sex without protection. Always practice safer sex by using a latex or polyurethane condom to lower the chance of sexual contact with semen, vaginal secretions, or blood. 

Epivir Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Epivir there are no specific foods that you must exclude from your diet when receiving Epivir.

Inform MD

Before receiving Epivir, tell your doctor if you:

  • are allergic to Epivir or any of the other ingredients of Epivir
  • have ever had liver disease such as liver failure, cirrhosis, or hepatitis
  • are seriously overweight (especially if you’re a woman)
  • are diabetic (Epivir solution contains sucrose)
  • use insulin
  • have kidney disease
  • have had pancreatitis (inflammation of the pancreas) in the past, particularly children

Tell your doctor if you are pregnant or breastfeeding.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.


Epivir and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category C. It is not known if Epivir will harm your unborn baby. There are no adequate and well-controlled trials of Epivir in pregnant women.

Epivir and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed. It is very important that you speak with your doctor about the best way to feed your baby. If your baby does not already have HIV, there is a chance that it can be transmitted through breastfeeding. The Centers for Disease Control and Prevention recommends that women with HIV do not breastfeed.

Epivir Usage

Epivir comes as a tablet and liquid to take by mouth, usually once daily or every 12 hours (twice a day) in combination with other antiretroviral medications. Epivir can be taken with or without food.

Take Epivir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take Epivir even if you feel well. Do not stop taking Epivir without talking to your doctor.

If you miss a dose, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Epivir Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your kidney function
  • your weight
  • your height
  • your age
  • your gender

Adults, for the treatment of HIV:

  • The recommended dose of Epivir (lamivudine) in HIV infected adults and adolescents over 16 years of age is 300 mg daily, taken by mouth, as either 150 mg twice daily or 300 mg once daily.
  • The dose may be decreased if you have kidney problems. 

Children, for the treatment of HIV:

  • The recommended dose of Epivir (lamivudine) oral solution in HIV infected children 3 months to 16 years of age is based on the child's weight. The recommendation is 4 mg/kg twice daily or 8 mg/kg once daily (up to a maximum of 300 mg daily), taken by mouth, in combination with other antiretroviral agents.
  • Children weighing at least 14 kg, can be given Epivir (lamivudine) tablets.


Epivir Overdose

If you take too much Epivir, call your local Poison Control Center or seek emergency medical attention right away.

Other Requirements

  • Store Epivir tablets at room temperature between 15° to 30°C (59° to 86°F).
  • Epivir oral solution does not require refrigeration, but should be stored tightly closed in a cool place.
  • Keep this and all medicines out of the reach of children.

Epivir FDA Warning


Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues alone or in combination, including Epivir and other antiretrovirals. Suspend treatment if clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity occur.

Severe acute exacerbations of hepatitis B have been reported in patients who are co-infected with hepatitis B virus (HBV) and human immunodeficiency virus (HIV-1) and have discontinued Epivir. Hepatic function should be monitored closely with both clinical and laboratory follow-up for at least several months in patients who discontinue Epivir and are co-infected with HIV-1 and HBV. If appropriate, initiation of anti-hepatitis B therapy may be warranted.

Epivir which is used to treat HIV-1 infection, contains a higher dose of the active ingredient (lamivudine) than Epivir-HBV which is used to treat chronic HBV infection. Patients with HIV-1 infection should receive only dosage forms appropriate for treatment of HIV-1.