Elspar

Elspar treats a certain type of leukemia. Tell your doctor right away if you notice a fever and sore throat.

Elspar Overview

Updated: 

Elspar is a prescription medicine approved for use with other chemotherapy drugs to treat a certain type of acute lymphocytic leukemia (ALL is a type of cancer of the white blood cells). Elspar belongs to a group of drugs called enzymes. This specific enzyme works by interfering with natural substances necessary for cancer cell growth.

Elspar comes as a solution that is injected into a vein (IV) or muscle (IM) by a healthcare provider at a medical facility.

Common side effects of Elspar include serious hypersensitivity reactions, nausea, vomiting, and elevated blood sugar levels.

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  • Other
  • Lymphoma
  • Precursor Cell Lymphoblastic Leukemia-lymphoma

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Uses of Elspar

Elspar is a prescription medicine approved for use with other chemotherapy drugs to treat a certain type of acute lymphocytic leukemia (ALL; a type of cancer of the white blood cells).

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Elspar Drug Class

Elspar is part of the drug class:

Side Effects of Elspar

Contact your doctor or seek emergency medical attention right away if you experience any of the following serious side effects:

  • swelling of the face, arms or legs, with or without pain in the arm or leg
  • difficulty breathing or shortness of breath
  • severe headache, seizures, confusion, hallucinations (seeing things or hearing voices that do not exist)
  • chest pain
  • severe abdominal (stomach) pain that begins in the stomach area, but may spread to the back
  • excessive thirst or urination
  • dark colored urine

Other more common, less severe side effects of this medication include:

  • nausea
  • vomiting
  • weight loss
  • tiredness
  • fever
  • headache

This is not a complete list of Elspar side effects. Ask your doctor or pharmacist for more information.

 

Elspar Interactions

No Elspar drug interactions have been identified, however, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Elspar Precautions

Do not receive Elspar if you are allergic to Elspar or pegaspargase (Oncaspar).

Serious allergic reactions can occur in people who receive Elspar . The risk of serious allergic reactions is higher in people who have previously received Elspar or similar medicines. Get emergency medical attention if you develop hives, difficulty breathing, or swelling of your face, lips, tongue, or throat. You may have an allergic reaction to this medication at any time, even if you previously received Elspar without reaction.

Blood clotting problems can occur with Elspar therapy including a serious condition in which a vein of the brain becomes clotted. Tell your doctor right away if you experience sudden headache, confusion, problems with vision, speech or balance.

Inflammation of the pancreas (pancreatitis), sometimes severe or causing death, can occur with Elspar therapy. Severe pain in your upper stomach spreading to your back as well as nausea and vomiting may be signs of pancreatitis. Tell your doctor right away if you experience these symptoms.

Glucose intolerance, or impaired insulin secretion and impaired suppression of liver glucose output, has occurred with Elspar use.

Elspar may cause damage or injury to the liver (hepatotoxicity). Tell your doctor right away if you experience yellowing of the skin or eyes or dark colored urine.

Patients have been reported to develop posterior reversible encephalopathy syndrome (PRES). PRES is a neurological disorder with symptoms of headache, seizures, visual disturbances, altered mental status, and hypertension. If PRES is suspected or diagnosed, therapy with Elspar is recommended to be temporarily stopped.

Elspar Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Elspar there are no specific foods that you must exclude from your diet when receiving Elspar.

 

Inform MD

Before receiving Elspar, tell your doctor about all of your medical conditions including if you:

  • are allergic to Elspar, pegaspargase (Oncaspar), or any other medicines
  • have or ever had pancreatitis (inflammation of the pancreas), liver disease, diabetes, blood clots, or severe bleeding
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

 

Elspar and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category C. There are no adequate and well-controlled studies of Elspar in pregnant women. Animal studies have not been done with Elspar. It is not known whether Elspar can cause harm to the unborn baby when given to a pregnant woman. Elspar should be given to a pregnant woman only if clearly needed.

Elspar and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if Elspar is excreted in human breast milk or if it will harm your nursing baby.

Elspar Usage

Elspar comes as a solution that is injected into a vein (IV) or muscle (IM) by a healthcare provider at a medical facility.

Elspar Overdose

If Elspar is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.