Elosulfase alfa

Elosulfase alfa is an enzyme used to treat patients with mucopolysaccharidosis type IVA, known as Morquio A syndrome. Elosulfase alfa has been associated with life-threatening anaphylactic reactions.

Elosulfase alfa Overview

Reviewed: December 15, 2014
Updated: 

Elosulfase alfa is a prescription medication used to treat patients with mucopolysaccharidosis type IVA, also known as Morquio A syndrome.

Elosulfase alfa is a hydrolytic lysosomal glycosaminoglycan-specific enzyme.  It works by correcting a deficiency in lysosomal enzymes, which are normally produced by the body.

This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

Common side effects of elosulfase alfa include fever, vomiting, headache, nausea, abdominal pain, chills, and fatigue.

Patient Ratings for

How was your experience with ?

First, a little about yourself

Tell us about yourself in a few words?

What tips would you provide a friend before taking ?

What are you taking for?

Choose one
  • Other

How long have you been taking it?

Choose one
  • Less than a week
  • A couple weeks
  • A month or so
  • A few months
  • A year or so
  • Two years or more

How well did work for you?

Did you experience many side effects while taking this drug?

How likely would you be to recommend to a friend?

Uses of Elosulfase alfa

Elosulfase alfa is a prescription medication used to treat patients with mucopolysaccharidosis type IVA, also known as Morquio A syndrome.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Elosulfase alfa Brand Names

Elosulfase alfa may be found in some form under the following brand names:

Side Effects of Elosulfase alfa

Serious side effects have been reported with elosulfase alfa. See the “Elosulfase alfa Precautions” section.

Common side effects of elosulfase alfa include the following:

  • fever
  • vomiting
  • headache
  • nausea
  • abdominal pain
  • chills
  • fatigue

This is not a complete list of elosulfase alfa side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Elosulfase alfa Interactions

No drug interactions have been determined by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Elosulfase alfa Precautions

Serious side effects have been reported with elosulfase alfa including the following:

  • Anaphylaxis and hypersensitivity reactions. Tell your healthcare provider right away if you have some or all of the following symptoms of anaphylaxis and hypersensitivity reactions:
    • cough
    • throat tightness
    • hives
    • flushing
    • decreased blood pressure
    • rash
    • shortness of breath
    • chest discomfort
  • Acute respiratory complications. Patients with a fever or respiratory illness at the time of infusion of elosulfase alfa may be at increased risk of anaphylaxis and hypersensitivity reactions.

Do not take elosulfase alfa if you:

  • are allergic to elosulfase alfa or to any of its ingredients 

Elosulfase alfa Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of elosulfase alfa, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking elosulfase alfa, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to elosulfase alfa or to any of its ingredients
  • have a fever
  • have a respiratory illness
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Elosulfase alfa and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Elosulfase alfa falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

There is a Morquio A Registry that collects data on pregnancy women with mucopolysaccharidosis type IVA who are treated with elosulfase alfa.

Elosulfase alfa and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if elosulfase alfa crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using elosulfase alfa.

Elosulfase alfa Usage

Take elosulfase alfa exactly as prescribed.

This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

Elosulfase alfa Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • your weight

The recommended dose of elosulfase alfa for the treatment of mucopolysaccharidosis type IVA is 2 mg/kg once weekly as an intravenous infusion given over 3.5 to 4.5 hours.  The infusion rate is based on the total volume administered, as well as the weight of the patient.

Elosulfase alfa Overdose

If you take too much elosulfase alfa, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If elosulfase alfa is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Store elosulfase alfa at room temperature. Once the product is diluted, it must be used immediately.
  • Protect from light.

Elosulfase alfa FDA Warning

WARNING: RISK OF ANAPHYLAXIS

Life-threatening anaphylactic reactions have occurred in some patients during Vimizim infusions. Anaphylaxis, presenting as cough, erythema, throat tightness, urticaria, flushing, cyanosis, hypotension, rash, dyspnea, chest discomfort, and gastrointestinal symptoms (e.g., nausea, abdominal pain, retching, and vomiting) in conjunction with urticaria, have been reported to occur during Vimizim infusions, regardless of duration of the course of treatment. Closely observe patients during and after Vimizim administration and be prepared to manage anaphylaxis. Inform patients of the signs and symptoms of anaphylaxis and have them seek immediate medical care should symptoms occur.  Patients with acute respiratory illness may be at risk of serious acute exacerbation of their respiratory compromise due to hypersensitivity reactions, and require additional monitoring.