Egrifta

Egrifta reduces excess fat in the stomach area in HIV infected patients with lipodystrophy. Be sure to change the injection site on your stomach area with each dose.

Egrifta Overview

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Egrifta is a prescription medication used to reduce excess abdominal (stomach area) fat in HIV-infected patients with lipodystrophy (increased body fat in certain areas of the body). This medication belongs to a group of drugs called human growth hormone-releasing factor (GRF) analogs. It works by stimulating the synthesis and release of growth hormone which helps break down fatty tissue. 

Egrifta comes in an injectable form to be injected just under the skin (subcutaneously) of the stomach area. It is usually injected once daily.

Common side effects include joint pain, pain in arms and legs, and swelling in the legs.

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Uses of Egrifta

Egrifta is a prescription medication used to reduce excess abdominal fat in HIV-infected patients with lipodystrophy.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Egrifta Drug Class

Egrifta is part of the drug class:

Side Effects of Egrifta

Common side effects include:

  • joint pain
  • pain in legs and arms
  • swelling in your legs
  • muscle soreness
  • tingling, numbness and pricking
  • nausea
  • vomiting
  • rash
  • itching

This is not a complete list of Egrifta side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Egrifta Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • steroids such as prednisone (Cortan, Deltasone, Orasone, Sterapred), budesonide (Entocort), dexamethasone (Decadron), triamcinolone (Kenacort, Aristocort), flunisolide (AeroBid. Aerospan), ciclesonide (Alvesco), mometasone (Asmanex, Dulera), fluticasone (Flovent), methylprednisolone (Medrol, Solu-Medrol), fludrocortisone (Florinef), and hydrocortisone (Cortef, Cortril, Hydrocortone)
  • ritonavir (Norvir)

This is not a complete list of Egrifta drug interactions. Ask your doctor or pharmacist for more information.

Egrifta Precautions

Serious side effects have been reported with Egrifta including the following:

  • serious allergic reactions. Some people taking Egrifta may have an allergic reaction. Stop using Egrifta and get emergency help right away if you have any of the following symptoms: a rash over your body, hives, swelling of your face or throat, shortness of breath or trouble breathing, fast heartbeat, or feeling of faintness or fainting.
  • swelling (fluid retention). Egrifta can cause swelling in some parts of your body. Call your healthcare provider if you have an increase in joint pain, or pain or numbness in your hands or wrist (carpal tunnel syndrome).
  • an increase in glucose (blood sugar). Your healthcare provider will measure your blood sugar periodically.
  • injection site reactions. Change (rotate) your injection site to help lower your risk for injection site reactions. Call your healthcare provider for medical advice if you have the following symptoms around the area of the injection site: redness, itching, pain, irritation, bleeding, rash, or swelling.

Do not take Egrifta if you:

  • are allergic to Egrifta or to any of its ingredients
  • have a pituitary gland tumor, pituitary gland surgery or other problems related to your pituitary gland
  • have active cancer (either newly diagnosed or recurrent) or are receiving treatment for cancer
  • are pregnant or become pregnant. If you become pregnant, stop using Egrifta and talk to your healthcare provider

Egrifta Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Egrifta, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Egrifta, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Egrifta or to any of its ingredients
  • have or have had cancer
  • have diabetes
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed
  • have kidney or liver problems
  • have any other medical condition

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Egrifta and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories-A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Egrifta falls into category X. It has been shown that women taking Egrifta during pregnancy may have babies born with problems. There are no situations where the benefits of the medication for the mother outweigh the risks of harm to the baby. These medicines should never be used by pregnant women.

If you become pregnant, stop using Egrifta and talk to your healthcare provider immediately.

Egrifta and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Egrifta passes into your breast milk. The Centers for Disease Control and Prevention (CDC) recommends that HIV-infected mothers not breastfeed to avoid the risk of passing HIV infection to your baby. Talk to your healthcare provider about the best way to feed your baby if you are taking Egrifta.

Egrifta Usage

Take Egrifta exactly as prescribed.

This medication is available in an injectable form to be given directly under the skin (subcutaneously) of your stomach area.

After mixing Egrifta with sterile water for Injection, it should look clear and colorless, with no particles in it. Do not use Egrifta if it looks cloudy, discolored, or if you see particles in it.

Do not use Egrifta after the date on the medication box and Egrifta vial. Do not use a syringe or needle more than one time.

Do not share your Egrifta needles with another person. Sharing needles can result in the transmission of infectious diseases, such as HIV. Do not share your Egrifta syringe with another person, even if the needle is changed.

You should inject Egrifta into the skin on your stomach. Pick an injection site that is around your belly button to the left or right. Stay away from any area with scar tissue, bruises, reddening, infection, or irritation.

Change your injection site from one day to the next to prevent bruising or irritation.

Do not recap the needle or remove the needle from the syringe after you inject Egrifta. Put your used Egrifta needles and syringes in an FDA-cleared sharps disposal container right away after use. Do not throw away loose needles and syringes in your household trash.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Egrifta at the same time.

Egrifta Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your weight
  • your height
  • your age
  • your gender

The recommended dose of Egrifta is 2 mg injected directly under the skin (subcutaneously) once a day.

Egrifta Overdose

If you take too much Egrifta, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store the medication box of Egrifta vials in the refrigerator.
  • Store the injection box of sterile water for Injection, syringes, and needles at room temperature.
  • Keep Egrifta vials away from light.
  • After mixing, use Egrifta right away and throw away any unused Egrifta. Do not store mixed Egrifta. Throw away the used bottle of sterile water for Injection.
  • Do not use Egrifta after the expiration date printed on the medication box and vial labels.
  • Keep this and all medicines out of the reach of children.