Dysport

Dysport treats muscle problems of the neck, elbows, wrists, and fingers. It is also used to treat frown lines (wrinkles) between the eyebrows.

Dysport Overview

Reviewed: August 4, 2016
Updated: 

Dysport is a prescription medication used to treat muscle problems of the neck, elbows, wrists, and fingers. It is also used to treat frown lines (wrinkles) between the eyebrows.

Dysport is a toxin produced by bacteria. It belongs to a class of drugs called neurotoxins, which relax muscles by decreasing nerve signals to those muscles.

This medication comes in an injectable form and is injected into the muscle (IM) by a healthcare professional.

Common side effects include muscle weakness or pain, and stuffy or runny nose and sore throat. Dysport may cause dizziness and eye problems including blurred vision and drooping eyelids. If this happens, do not drive a motor vehicle or participate in other dangerous activities.

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Dysport Cautionary Labels

precautions

Uses of Dysport

Dysport is a prescription medicine that is injected into muscles and used:

  • to treat cervical dystonia (CD) in adults
  • to improve the look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults younger than 65 years of age for a short period of time (temporary)
  • to treat increased muscle stiffness in, elbow, wrist, and finger muscles in adults with upper limb spasticity
  • to treat increased muscle stiffness in calf muscles in children 2 years of age and older with lower limb spasticity.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Dysport Drug Class

Dysport is part of the drug class:

Side Effects of Dysport

Dysport can cause serious side effects including swallowing and breathing difficulties that can be life-threatening. See the FDA Black Box Warning and "Drug Precautions" sections.

The most common side effects of Dysport in people with cervical dystonia include:

• muscle weakness
• dry mouth
• feeling of tiredness
• muscle pain
• problems speaking
• eye problems
• difficulty swallowing
• headache

The most common side effects of Dysport in people with glabellar lines include:

• stuffy or runny nose and sore throat
• injection site pain
• upper respiratory infection
• blood in urine• headache
• injection site reaction
• swelling of eyelids
• drooping eyelids
• sinus infection
• nausea

The most common side effects of Dysport in  adults with upper limb spasticity include:

• urinary tract infection
• muscle weakness
• musculoskeletal pain
• fall
• depression
• stuffy or runny nose and sore throat
• dizziness

These are not all the possible side effects of Dysport. Talk to your doctor or pharmacist for more information.

Dysport Interactions

Tell your doctor about all the medicines you take including prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products. Especially tell your doctor if you take:

  • amikacin
  • clindamycin (Cleocin)
  • colistimethate (Coly-Mycin)
  • gentamicin
  • kanamycin
  • lincomycin (Lincocin)
  • neomycin (Neo-Fradin, Neo-Rx)
  • polymyxin
  • streptomycin
  • tobramycin (Tobi)
  • cholinesterase inhibitors such as ambenonium (Mytelase)
  • donepezil (Aricept)
  • galantamine (Razadyne)
  • neostigmine (Prostigmin)
  • physostigmine
  • pyridostigmine (Mestinon, Regonol)
  • rivastigmine (Exelon)
  • tacrine (Cognex)
  • magnesium sulfate
  • medications for allergies, colds, or sleep
  • muscle relaxants
  • quinidine

Also tell your doctor if you have received injections of any botulinum toxin product in the past four months. 

This is not a complete list of Dysport drug interactions. Ask your doctor or pharmacist for more information.

Dysport Precautions

Dysport may cause serious side effects that can be life-threatening, including:

  • Problems breathing or swallowing
  • Botulism. Spread of toxin effects. Seek emergency medical attention if you experience symptoms of botulism including:
    • loss of strength and muscle weakness all over the body
    • double vision
    • blurred vision and drooping eyelids
    • hoarseness or change or loss of voice (dysphonia)
    • trouble saying words clearly (dysarthria)
    • loss of bladder control
    • trouble breathing
    • trouble swallowing

These problems can happen hours, days, to weeks after an injection of Dysport. Call your doctor or get medical help right away if you have any of these problems after treatment with Dysport.

Do not take Dysport if you:

  • are allergic to any of the ingredients in Dysport
  • are allergic to cow's milk protein
  • had an allergic reaction to any other botulinum toxin product such as Myobloc, Botox, or Xeomin
  • have a skin infection at the planned injection site

Dysport may cause loss of strength or general muscle weakness, or vision problems within hours to weeks of taking Dysport. If this happens, do not drive a car, operate machinery, or do other dangerous activities.

Dysport Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Dysport there are no specific foods that you must exclude from your diet when receiving Dysport.

Inform MD

Before receiving Dysport tell your doctor about all your medical conditions, including if you:

  • have a disease that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou Gehrig's disease], myasthenia gravis or Lambert-Eaton syndrome)
  • have allergies to any botulinum toxin product
  • had any side effect from any botulinum toxin product in the past
  • have or have had a breathing problem, such as asthma or emphysema
  • have or have had swallowing problems
  • have or have had bleeding problems
  • have diabetes
  • have plans to have surgery
  • had surgery on your face
  • have weakness of your forehead muscles, such as trouble raising your eyebrows
  • have drooping eyelids
  • have any other change in the way your face normally looks

Tell your doctor if you are pregnant or breastfeeding.

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal products. 

Dysport and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

There are no well-controlled studies that have been done in pregnant women. Dysport should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.

Dysport and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Dysport is excreted in human breast milk or if it will harm your baby.

Dysport Usage

  • Dysport is an injection that your doctor will give you.
  • Dysport is injected into the affected muscles.

Dysport Dosage

  • Your doctor may change your dose of Dysport, until you and your doctor find the best dose for you.
  • Your doctor will tell you how often you will receive your dose of Dysport injections.

Indication-specific dosage and administration recommendations should be followed. Dysport should not be administered more frequently than every 12 weeks.

Dysport Overdose

Symptoms of overdose after Dysport injection may include difficulty breathing, difficulty moving parts of the body, and weakness. These symptoms may not appear right away. Call your doctor or seek emergency medical attention right away if you experience any of these symptoms.

Dysport FDA Warning

WARNING: DISTANT SPREAD OF TOXIN EFFECT
The effects of Dysport and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life-threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can occur in adults, particularly in those patients who have underlying conditions that would predispose them to these symptoms.