Diflucan

Diflucan is an antifungal medicine. It is used to treat and prevent yeast infections. Usually prescribed as a single dose. However, more than one dose may be required.

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Pharmacist Bethany Muhlstein, PharmD overviews the uses and common side effects of Diflucan
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Pharmacist Bethany Muhlstein, PharmD overviews the uses and common side effects of Diflucan
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Diflucan Overview

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Diflucan is a prescription medication used to treat fungal infections in various parts of the body including the mouth, throat, genitals, brain, urinary tract, lungs and other organs. It is also used to prevent fungal infection in people with a weak immune system. Diflucan is in a group of drugs called azole antifungals which work by inhibiting a fungal enzyme needed for the fungus to grow.

This medication comes in tablet and oral suspension forms to be taken by mouth and is usually taken once a day, with or without food.

Diflucan is also available as an injectable to be injected into the vein (IV) by a healtchare professional. 

Common side effects include headache, diarrhea, nausea, and dizziness. Do not drive or operate machinery until you know how Diflucan will affect you.

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What are you taking Diflucan for?

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  • Other
  • Aids-related Opportunistic Infections
  • Blastomycosis
  • Candidiasis, Chronic Mucocutaneous
  • Candidiasis, Oral
  • Candidiasis, Vulvovaginal
  • Coccidioidomycosis
  • Fungemia
  • Histoplasmosis
  • Meningitis, Cryptococcal
  • Mycoses

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  • Less than a week
  • A couple weeks
  • A month or so
  • A few months
  • A year or so
  • Two years or more

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Diflucan Cautionary Labels

precautionsprecautionsprecautions

Uses of Diflucan

Diflucan is a prescription medication used to treat fungal infections in various parts of the body including the mouth, throat, genitals, brain, urinary tract, lungs and other organs. It is also used to prevent fungal infection in people with a weak immune system.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Diflucan Drug Class

Diflucan is part of the drug class:

Side Effects of Diflucan

Like all medicines, Diflucan may cause some side effects that are usually mild to moderate.

The most common side effects of Diflucan are:

  • headache
  • diarrhea
  • nausea or upset stomach
  • dizziness
  • stomach pain
  • changes in the way food tastes

Allergic reactions to Diflucan are rare, but they can be very serious if not treated right away by a doctor. If you cannot reach your doctor, go to the nearest hospital emergency room. Signs of an allergic reaction can include:

  • shortness of breath
  • coughing
  • wheezing
  • fever
  • chills
  • throbbing of the heart or ears
  • swelling of the eyelids, face, mouth, neck, or any other part of the body
  • skin rash, hives, blisters or skin peeling

Diflucan has been linked to rare cases of serious liver damage, including deaths, mostly in patients with serious medical problems. Call your doctor if:

  • your skin or eyes become yellow
  • your urine turns a darker color
  • your stools (bowel movements) are light-colored
  • you vomit or feel like vomiting
  • you have severe skin itching

Diflucan may cause other less common side effects besides those listed here. If you develop any side effects that concern you, call your doctor. For a list of all side effects, ask your doctor or pharmacist.

Diflucan Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • diabetes medicines such as glyburide, tolbutamide, glipizide
  • blood pressure medicines like hydrochlorothiazide, losartan, amlodipine, nifedipine or felodipine
  • blood thinners such as warfarin
  • cyclosporine, tacrolimus or sirolimus (used to prevent rejection of organ transplants)
  • rifampin or rifabutin for tuberculosis
  • astemizole for allergies
  • phenytoin or carbamazepine to control seizures
  • theophylline to control asthma
  • cisapride for heartburn
  • quinidine (used to correct disturbances in heart rhythm)
  • amitriptyline or nortriptyline for depression
  • pimozide for psychiatric illness
  • amphotericin B or voriconazole for fungal infections
  • erythromycin for bacterial infections
  • cyclophosphamide or vinca alkaloids such as vincristine or vinblastine for treatment of cancer
  • fentanyl, afentanil or methadone for chronic pain
  • halofantrine for malaria
  • lipid lowering drugs such as atorvastatin, simvastatin, and fluvastatin
  • non-steroidal anti-inflammatory drugs including celecoxib, ibuprofen, and naproxen
  • prednisone, a steroid used to treat skin, gastrointestinal, hematological or respiratory disorders
  • antiviral medications used to treat HIV like saquinavir or zidovudine
  • vitamin A nutritional supplement
  • tofacitinib (Xeljanz)

This is not a complete list of Diflucan drug interactions. Ask your doctor or pharmacist for more information.

Diflucan Precautions

To avoid a possible serious reaction, do NOT take Diflucan if you are taking erythromycin, astemizole, pimozide, quinidine, and cisapride (Propulsid) since it can cause changes in heartbeat in some people if taken with Diflucan. See "Diflucan Interactions".

Allergic reactions to Diflucan are rare, but they can be very serious if not treated right away by a doctor. If you cannot reach your doctor, go to the nearest hospital emergency room. Signs of an allergic reaction can include shortness of breath; coughing; wheezing; fever; chills; throbbing of the heart or ears; swelling of the eyelids, face, mouth, neck, or any other part of the body; or skin rash, hives, blisters or skin peeling.

Diflucan has been linked to rare cases of serious liver damage, including deaths, mostly in patients with serious medical problems. Call your doctor if your skin or eyes become yellow, your urine turns a darker color, your stools (bowel movements) are light-colored, or if you vomit or feel like vomiting or if you have severe skin itching.

In patients with serious conditions such as AIDS or cancer, rare cases of severe rashes with skin peeling have been reported. Tell your doctor right away if you get a rash while taking Diflucan.

Diflucan can cause dizziness. Do not drive or operate machinery until you know how Diflucan will affect you.

Diflucan Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Diflucan, there are no specific foods that you must exclude from your diet.

 

Inform MD

Before receiving this medication, tell your doctor if you:

  • are taking any over-the-counter medicines you can buy without a prescription, including natural or herbal remedies
  • have any liver problems
  • have any other medical conditions
  • are pregnant, plan to become pregnant, or think you might be pregnant. Your doctor will discuss whether Diflucan is right for you.
  • are breastfeeding. Diflucan can pass through breast milk to the baby.
  • are allergic to any other medicines including those used to treat yeast and other fungal infections.
  • are allergic to any of the ingredients in this medication 

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Diflucan and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category C if you are using a single 150 mg tablet for vaginal candidiasis infection. There are no well-done studies of Diflucan in pregnant women. Available human data do not suggest an increased risk of abnormalities single dose of 150 mg.

This medication falls into category D for all other types of infections. It has been shown that use of Diflucan in pregnant women caused some babies to be born with problems. However, in some serious situations, the benefit of using this medication may be greater than the risk of harm to the baby.

 

Diflucan and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Diflucan has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from fluconazole, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

 

Diflucan Usage

  • Take Diflucan by mouth with or without food. You can take Diflucan at any time of the day.
  • Diflucan keeps working for several days to treat the infection. Generally the symptoms start to go away after 24 hours. However, it may take several days for your symptoms to go away completely. If there is no change in your symptoms after a few days, call your doctor.
  • Just swallow 1 Diflucan tablet to treat your vaginal yeast infection.
  • Diflucan is also available as an injectable to be injected into the vein (IV) by a healtchare professional. 
  • Some medicines can affect how well Diflucan works. Check with your doctor before starting any new medicines within seven days of taking Diflucan.

Diflucan Dosage

Take Diflucan exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The Diflucan dose your doctor recommends will be based on the following the condition being treated

  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your weight
  • your age

The recommended dose of Diflucan for the treatment of vaginal candidiasis in adults is 150 mg as a one-time dose.

The recommended dose of Diflucan for the treatment of oropharyngeal candidiasis in adults is 200 mg on the first day, followed by 100 mg once daily.

The recommended dose of Diflucan for the treatment of esophageal candidiasis in adults is 200 mg on the first day, followed by 100 mg to 400 mg once daily.

The recommended dose of Diflucan for the treatment of systemic candida infections in adults is up to 400 mg once daily.

The recommended dose of Diflucan for the treatment of UTIs and peritonitis in adults is 50 mg to 200 mg once daily.

The recommended dose of Diflucan for the treatment of cryptococcal meningitis in adults is 400 mg on the first day, followed by 200 mg to 400 mg once daily.

The recommended dose of Diflucan to prevent infection in adults undergoing bone marrow transplant is 400 mg once daily.

The recommended dose of Diflucan for the treatment of oropharyngeal candidiasis in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily.

The recommended dose of Diflucan for the treatment of esophageal candidiasis in children is 6 mg/kg on the first day, followed by 3 mg/kg to 12 mg/kg once daily.

The recommended dose of Diflucan for the treatment of systemic candida infections in children is 6-12 mg/kg once daily.

The recommended dose of Diflucan for the treatment of cryptococcal meningitis in children is 12 mg/kg on the first day, followed by 6 mg/kg to 12 mg/kg once daily.

Diflucan Overdose

If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If this medication is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Keep Diflucan and all medicines out of the reach of children.
  • Store tablets below 86°F (30°C).
  • Store dry powder below 86°F (30°C). Store reconstituted suspension between 86°F (30°C) and 41°F (5°C) and discard unused portion after 2 weeks. Protect from freezing.