Detrol

Detrol Overview

Detrol (generic: tolterodine) is a prescription medication used to treat the symptoms of an overactive bladder in adults.  Detrol belongs to a group of drugs called antimuscarinic medications, which help the bladder muscles to relax.

This medication comes in tablet form and is usually taken twice a day, with or without food.

Common side effects of Detrol include dry mouth, dizziness, and headache. 

Uses of Detrol

Detrol is a prescription medicine for adults used to treat the following symptoms due to a condition called overactive bladder:

  • urge urinary incontinence: a strong need to urinate with leaking or wetting accidents
  • urgency: a strong need to urinate right away
  • frequency: urinating often

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Side Effects of Detrol

The most common side effects with Detrol are:

  • dry mouth
  • dizziness
  • headache
  • stomach pain
  • constipation

This is not a complete list of side effects of Detrol. Talk to your doctor about any side effect that is bothersome or does not go away.

Detrol Interactions

Tell your doctor about all the medicines you take or are planning to take includine prescription and non-prescription medicines, vitamins, and herbal supplements. If you take Detrol with other medicines, the effects of either could be increased, decreased, or altered. Especially tell your doctor if you take:

  • clarithromycin
  • cyclosporin
  • erythromycin
  • itraconazole
  • ketoconazole
  • miconazole
  • vinblastine

 

Detrol Precautions

Do not take Detrol if you

  • are not able to empty your bladder (urinary retention)
  • have delayed or slow emptying of your stomach (gastric retention)
  • have an eye problem called "uncontrolled narrow-angle glaucoma"
  • are allergic to Detrol or to any of its ingredients.

Medicines like Detrol can cause blurred vision or drowsiness. Use caution while driving or doing other dangerous activities until you know how Detrol affects you.

Detrol Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Detrol there are no specific foods that you must exclude from your diet when receiving Detrol.

Inform MD

Before starting Detrol, tell your doctor about all of your medical and other conditions that may affect the use of Detrol, including

  • stomach or intestinal problems or problems with constipation
  • problems emptying your bladder or if you have a weak urine stream
  • treatment for an eye problem called narrow-angle glaucoma
  • liver problems
  • kidney problems
  • a condition called myasthenia gravis
  • if you or any family members have a rare heart condition called QT prolongation (long QT syndrome)
  • if you are pregnant or trying to become pregnant. It is not known if Detrol could harm your unborn baby.
  • if you are breastfeeding. It is not known if Detrol passes into your breast milk or if it can harm your baby. Talk to your doctor about the best way to feed your baby if you take Detrol.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Other medicines can affect how your body handles Detrol.

Your doctor may use a lower dose of Detrol if you are taking:

  • Certain medicines for fungus or yeast infections
  • Certain medicines for bacterial infections
  • Sandimmune (cyclosporine) or Velban (vinblastine)

Detrol and Pregnancy

Tell your doctor if you are pregnant or if you are planning to become pregnant. It is not known if Detrol will harm your unborn baby.

Detrol and Lactation

Tell your doctor if you are breastfeeding or if you are planning to breastfeed. It is not known if Detrol is excreted in human breast milk or if it will harm your nursing baby.

Detrol Usage

Take Detrol exactly as your doctor tells you to take it. Your doctor will tell you how many Detrol tablets to take and when to take them.

  • Do not change your dose unless told to do so by your doctor.
  • You can take Detrol with or without food.
  • Take Detrol at the same times each day.
  • If you miss a dose of Detrol, just take your next regular dose at your next regular time. Do not try to make up for your missed dose.
  • If you take too much Detrol, call your doctor, or go to the hospital emergency room right away.

Medicines like Detrol can cause blurred vision or drowsiness. Use caution while driving or doing other dangerous activities until you know how Detrol affects you.

Detrol Dosage

Take Detrol exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The initial recommended dose of Detrol Tablets is 2 mg twice daily. The dose may be lowered to 1 mg twice daily based on individual response and tolerability. For patients with significantly reduced hepatic or renal function or who are currently taking drugs that are potent inhibitors of CYP3A4, the recommended dose of Detrol is 1 mg twice daily.

he recommended dose of Detrol LA Capsules is 4 mg once daily with water and swallowed whole.. The dose may be lowered to 2 mg daily based on individual response and tolerability; however, limited efficacy data are available for Detrol LA 2 mg.

Dosage Adjustment in Specific Populations

For patients with mild to moderate hepatic impairment (Child-Pugh Class A or B) or severe renal impairment (CCr 10 – 30 mL/min), the recommended dose of Detrol LA is 2 mg once daily. Detrol LA is not recommended for use in patients with severe hepatic impairment (Child-Pugh Class C). Patients with CCr  less than 10 mL/min have not been studied and use of Detrol LA in this population is not recommended.

Detrol Overdose

If you take too much Detrol (more than the prescribed amount) call your doctor or your local Poison Control Center right away.

Forms of Detrol

Detrol is available in 1 mg and 2 mg strength tablets. The active ingredient in Detrol is tolterodine.

Detrol Active ingredients: tolterodine tartrate

Inactive ingredients: colloidal anhydrous silica, calcium hydrogen phosphate dihydrate, cellulose microcrystalline, hypromellose, magnesium stearate, sodium starch glycolate (pH 3.0 to 5.0), stearic acid, and titanium dioxide.

Detrol LA Active ingredients: tolterodine tartrate

Inactive ingredients: sucrose, starch, hypromellose, ethylcellulose, medium chain triglycerides, oleic acid, gelatin, and FD&C Blue #2. 2 mg capsule also contains yellow iron oxide. Capsules have pharmaceutical grade printing ink that contains shellac glaze, titanium dioxide, propylene glycol, and simethicone.

Other Requirements

Store Detrol at room temperature (59 to 86° F).
Keep it in a dry place.
Keep Detrol and all medicines out of the reach of children.

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Reviewed by: 
Beth Bolt, RPh
Last Updated:
February 14, 2013
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