Defibrotide

treats severe hepatic (liver) veno-occlusive disease (VOD) which may occur after receiving chemotherapy and hematopoietic stem cell transplantation (HSCT).

Defibrotide Overview

Updated: 

Defibrotide is a prescription medication used to treat severe hepatic (liver) veno-occlusive disease (VOD).

This medication is available as an injection and is administered by a healthcare professional. 

Common side effects of defibrotide include abnormally low blood pressure, diarrhea, vomiting, nausea, and nosebleeds.

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Uses of Defibrotide

Defibrotide is a prescription medication used to treat severe hepatic (liver) veno-occlusive disease (VOD).

VOD can occur after receiving chemotherapy and hematopoietic stem cell transplantation (HSCT). HSCT is a procedure performed in some patients to treat certain blood or bone marrow cancers.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Defibrotide Brand Names

Defibrotide may be found in some form under the following brand names:

Side Effects of Defibrotide

Serious side effects have been reported with defibrotide. See the “Defibrotide Precautions” section.

Common side effects include the following:

  • low blood pressure
  • diarrhea
  • vomiting
  • nausea
  • nose bleeds

This is not a complete list of defibrotide side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.